Australian Journal of Chemistry Australian Journal of Chemistry Society
An international journal for chemical science
RESEARCH FRONT

An Injectable Double-Network Hydrogel for Cell Encapsulation

Pei Lin Chee A , Lakshmi Lakshmanan A , Shan Jiang A B , Hongye Ye A , Dan Kai A and Xian Jun Loh A C D E
+ Author Affiliations
- Author Affiliations

A Institute of Materials Research and Engineering (IMRE), Agency for Science, Technology and Research (A*STAR), 2 Fusionopolis Way, #08-03 Innovis, Singapore 138634, Republic of Singapore.

B College of Chemistry, Jilin University, Changchun 130012, China.

C Department of Materials Science and Engineering, National University of Singapore, 9 Engineering Drive 1, Singapore 117576, Republic of Singapore.

D Singapore Eye Research Institute, 11 Third Hospital Avenue, Singapore 168751, Republic of Singapore.

E Corresponding author. Email: lohxj@imre.a-star.edu.sg

Australian Journal of Chemistry 69(4) 388-393 https://doi.org/10.1071/CH15659
Submitted: 19 October 2015  Accepted: 13 November 2015   Published: 27 November 2015

Abstract

Further developing on the technique originally intended for the purpose of forming tough hydrogels, we showed in this study that the double-network system can also be used to synthesize an injectable gel. The gel was made up of poly(ethylene glycol) methyl ether methacrylate, sodium alginic acid, and calcium chloride, and two networks, consisting of ionic and covalent networks, were found to co-exist in the gel. Additionally, the rheology studies showed that the mechanical properties of the gel only deteriorated under high strain, demonstrating the robustness of the gel upon injection. The results of a cell cytotoxicity test and a preliminary cell encapsulation study were promising, showing good cell compatibility and thus suggesting that the hydrogels could potentially be used for cell delivery.


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