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The Evolution of New Catalytic Mechanisms for Xenobiotic Hydrolysis in Bacterial Metalloenzymes*

Elena Sugrue A , Carol J. Hartley B , Colin Scott B and Colin J. Jackson A C
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A Research School of Chemistry, Australian National University, Canberra, ACT 2601, Australia.

B CSIRO Land and Water, Canberra, ACT 2600, Australia.

C Corresponding author. Email: colin.jackson@anu.edu.au




Elena Sugrue is a Ph.D. scholar at the Research School of Chemistry, Australian National University (ANU). She completed her Bachelor of Science degree at the University of Canterbury, receiving first class honours before taking up doctoral studies at the ANU in 2013. Her research interests include investigating the chemical basis of biological function and how chemical and biophysical features can change over evolutionary trajectories.



Dr Carol Hartley is a research scientist and leader of the Biocatalysis and Synthetic Biology research team within the Commonwealth Scientific and Industrial Research Organisation (CSIRO) in Canberra, Australia. She obtained a Ph.D. in microbiology from Rhodes University, South Africa, before joining the CSIRO and has a strong interest in biocatalysis and the use of enzymes to advance biotechnology and synthetic biology.



Dr Colin Scott obtained his Ph.D. in molecular microbiology from the University of Sheffield in the UK in 2000 before taking up a post-doctoral fellowship with the Commonwealth Scientific and Industrial Research Organisation (CSIRO). He currently leads the Biotechnology and Synthetic Biology Group at the CSIRO. He has strong interests in enzyme evolution, biocatalysis, microbial physiology, and synthetic biology.



Associate Professor Colin Jackson has held research positions at the Commonwealth Scientific and Industrial Research Organisation (CSIRO) and was a visiting research fellow at the Weizmann Institute of Science (Rehovot, Israel) and a Marie Curie Research Fellow at the Institut de Biologie Structurale (Grenoble, France), before his appointment at the Research School of Chemistry at the Australian National University. He is an ARC Future Fellow and has been awarded an ARC DECRA, a Human Frontiers in Science Young Investigator Award, an AIPS Tall Poppy Award, ACT Tall Poppy of the Year, the 2015 ACT Scientist of the Year Award, and the 2015 RACI Rennie Memorial Medal.

Australian Journal of Chemistry 69(12) 1383-1395 https://doi.org/10.1071/CH16426
Submitted: 21 July 2016  Accepted: 6 September 2016   Published: 23 September 2016



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