
TY  - JOUR
A1  - Capon, RJ 
A1  - Macleod, JK 
T1  - Two Epimeric Dibromo Nitriles From the Australian Sponge <I>Aplysina laevis</I>
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1987
VL  - 40
IS  - 2
SP  - 341
EP  - 346
KW  - 
UR  - https://doi.org/10.1071/CH9870341 
N2  - Two dibromo nitriles, (1&#8242;R,5&#8242;S,6&#8242;S)-2-(3&#8242;,5&#8242;-dibromo-1&#8242;,6&#8242;-dihydroxy-4&#8242;-oxocyclohex-2&#8242;- enyl) acetonitrile (5) and the (l&#8242;R,5&#8242;R,6&#8242;S) epimer (6), possessing antimicrobial activity, have been isolated from the sponge Aplysina  laevis  (Carter). Cometabolites (+)-aeroplysinin-1 (1) and the dibromo ketone (2) were also identified. Structures (5) and (6) were assigned on the basis of spectroscopic evidence and synthesis from (1). 
ER  -

