
TY  - JOUR
A1  - Donati, C 
A1  - Prager, RH 
A1  - Weber, B 
T1  - Potential GABA<sub>B</sub> Receptor Antagonists. III. Folded Baclofen Analogs Based on Phthalide
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1989
VL  - 42
IS  - 6
SP  - 787
EP  - 795
KW  - 
UR  - https://doi.org/10.1071/CH9890787 
N2  - Possible analogues of baclofen, 3-aminomethyl-5-chloro-, 3-aminomethyl-6-chloro- and 3-aminomethyl-5,6-dichloro-isobenzofuran-1(3H)-one, have been prepared for evaluation as antispasticity agents. The corresponding 3-hydroxyisobenzofuran-l(3H)-one was reacted with ethyl acetoacetate under acidic conditions, and the keto ester hydrolysed and decarboxylated to give the 3-(2-oxopropyl)isobenzofuran-l(3H)-one; this was treated with hydrazoic acid, and the product was hydrolysed. A parallel series of (3-oxo-1,3-dihydroisobenzofuran-1-y1)glycines was obtained by treating the keto ester first with hydrazoic acid, and hydrolysis of the resulting acetamides. 
ER  -

