
TY  - JOUR
A1  - Perich, JW 
A1  - Johns, RB 
T1  - Synthesis of Casein-Related Peptides and Phosphopeptides. V. The Efficient Global 'Phosphite-Triester' Phosphorylation of Protected Serine Derivatives and Peptides by Using Dibenzyl or Di-t-butyl N,N-Diethylphosphoramidite
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1990
VL  - 43
IS  - 10
SP  - 1623
EP  - 1632
KW  - 
UR  - https://doi.org/10.1071/CH9901623 
N2  - Both dibenzyl N,N- diethylphosphoramidite and di -t-butyl N,N- diethylphosphoramidite are shown to be suitable reagents for the efficient 1H-tetrazole-catalysed 'phosphite-triester' phosphorylation of the protected serine derivative Boc-Ser-OCH2C6H4NO2-p. Both these reagents were also used for the phosphorylation of the protected serine derivative Boc-Glu ( OBut )-Ser- Leu-OBut, and subsequent hydrogenolytic treatment of Boc-Glu ( OBut )-Ser(PO3Bzl2)- Leu-OBut or acidolytic treatment of Boc-Glu ( OBut )-Ser(PO3But2)- Leu-OBut gave the O- phosphoseryl tripeptide Glu -Ser(PO3H2)- Leu in near-quantitive yield. 
ER  -

