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Article << Previous     |     Next >>   Contents Vol 23(3)

Negative impact of endocrine-disrupting compounds on human reproductive health

Damjan Balabanič A B E , Marjan Rupnik C and Aleksandra Krivograd Klemenčič D

A Pulp and Paper Institute, Bogišićeva ulica 8, SI-1000 Ljubljana, Slovenia.
B University of Nova Gorica, Vipavska 13, SI-5000 Nova Gorica, Slovenia.
C Institute of Physiology, Medical Faculty, University of Maribor, Slomškov trg 15, SI-2000 Maribor, Slovenia.
D Department of Sanitary Engineering, Faculty of Health Sciences, University of Ljubljana, Zdravstvena pot 5, SI-1000 Ljubljana, Slovenia.
E Corresponding author. Email: damjan.balabanic@gmail.com

Reproduction, Fertility and Development 23(3) 403-416 http://dx.doi.org/10.1071/RD09300
Submitted: 10 September 2009  Accepted: 9 September 2010   Published: 3 February 2011


 
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Abstract

There is increasing concern about chemical pollutants that are able to mimic hormones, the so-called endocrine-disrupting compounds (EDCs), because of their structural similarity to endogenous hormones, their ability to interact with hormone transport proteins or because of their potential to disrupt hormone metabolic pathways. Thus, the effects of endogenous hormones can be mimicked or, in some cases, completely blocked. A substantial number of environmental pollutants, such as polychlorinated biphenyls, dioxins, polycyclic aromatic hydrocarbons, phthalates, bisphenol A, pesticides, alkylphenols and heavy metals (arsenic, cadmium, lead, mercury), have been shown to disrupt endocrine function. These compounds can cause reproductive problems by decreasing sperm count and quality, increasing the number of testicular germ cells and causing male breast cancer, cryptorchidism, hypospadias, miscarriages, endometriosis, impaired fertility, irregularities of the menstrual cycle, and infertility. Although EDCs may be released into the environment in different ways, the main sources is industrial waste water. The present paper critically reviews the current knowledge of the impact of EDCs on reproductive disorders in humans.

Additional keywords: environment, reproductive problems, waste water.


References

Abernathy, C. O., Thomas, D. J., and Calderon, R. L. (2003). Health effects and risk assessment of arsenic. J. Nutr. 133, 1536–1538..

Agency for Toxic Substances and Disease Registry (ATSDR) (1997). ‘Toxicological Profile for Selected Polychlorinated Biphenyls: Update.’ (US Department of Health and Social Services, Public Health Service, Agency for Toxic Substances and Disease Registry: Atlanta, GA.)

Al-Saleh, I., Khalil, M., and Taylor, A. (1995). Lead, erythrocyte protoporphyrin and haematological parameters in normal maternal and umbilical cord blood from subjects of the Riyadh region. Arch. Environ. Health 50, 66–73.
CrossRef | CAS | PubMed |

Andersen, H. R., Cook, S. J., and Waldbillig, D. (2002). Effects of currently used pesticides in assays for estrogenicity, androgenicity, and aromatase activity in vitro. Toxicol. Appl. Pharmacol. 179, 1–12.
CrossRef | CAS | PubMed |

Anderson, H. A., and Wolff, M. S. (2000). Environmental contaminants in human milk. J. Expo. Anal. Environ. Epidemiol. 10, 755–760.
CrossRef | CAS | PubMed |

Auger, J., Kunstmann, J. M., Czyglik, F., and Jouannet, P. (1995). Decline in semen quality among fertile man in Paris during the past 20 years. N. Engl. J. Med. 332, 281–285.
CrossRef | CAS | PubMed |

Baccarelli, A., Pesatori, A. C., Masten, S. A., Patterson, D. G., Needham, L. L., Mocarelli, P., Caporaso, N. E., Consonni, D., Grassman, J. A., Bertazzi, P. A., and Landi, M. T. (2004). Aryl-hydrocarbon receptor-dependent pathway and toxic effects of TCDD in humans: a population-based study in Seveso, Italy. Toxicol. Lett. 149, 287–293.
CrossRef | CAS | PubMed |

Balabanič D., and Krivograd Klemenčič A.(2011). Presence of phthalates, bisphenol A, and nonylphenol in paper mill wastewaters in Slovenia and efficiency of aerobic and combined aerobic-anaerobic biological wastewater treatment plants for their removal. Fresen. Environ. Bull. 20, 86–92.

Balabanič D., Zule J., and Krivograd Klemenčič A. (2009). Are biological waste water treatment plants efficient for removal of potential endocrine disrupters? Papir 37, 25–28. [In Slovene]

Barlow, N. J., Phillips, S. L., Wallace, D. G., Sar, M., Gaido, K. W., and Foster, P. M. (2003). Quantitative changes in gene expression in fetal testis following exposure to di(n-butyl) phthalate. Toxicol. Sci. 73, 431–441.
CrossRef | CAS | PubMed |

Baskin, L. S., Himes, K., and Colborn, T. (2001). Hypospadias and endocrine disruption: is there a connection? Environ. Health Perspect. 109, 1175–1183.
CrossRef | CAS | PubMed |

Bellinger, D. C. (2005). Teratogen update: lead and pregnancy. Birth Defects Res. A Clin. Mol. Teratol. 73, 409–420.
CrossRef | CAS | PubMed |

Bergeron, R. M., Thompson, T. B., Leonard, L. S., Pluta, L., and Gaido, K. W. (1999). Estrogenicity of bisphenol A in a human endometrial carcinoma cell line. Mol. Cell. Endocrinol. 150, 179–187.
CrossRef | CAS | PubMed |

Birkett J. W. (2003). Scope of the problem. In ‘Endocrine Disrupters in Wastewater and Sludge Treatment Processes’. (Eds J. W. Birkett and J. N. Lester.) pp. 1–34. (Lewis Publishers: London.)

Brody, J. G., and Rudel, R. A. (2003). Environmental pollutants and breast cancer. Environ. Health Perspect. 111, 1007–1019..
| CAS | PubMed |

Brotons, J. A., Olea-Serrano, M. F., Villalobos, M., and Olea, N. (1995). Xenoestrogens released from lacquer coating in food cans. Environ. Health Perspect. 103, 608–612.
CrossRef | CAS | PubMed |

Carbone, P., Giordano, F., Nori, F., Mantovani, A., Taruscio, D., Lauria, L., and Figà-Talamanca, I. (2006). Cryptorchidism and hypospadias in the Sicilian district of Ragusa and the use of pesticides. Reprod. Toxicol. 22, 8–12.
CrossRef | CAS | PubMed |

Carlsen, E., Giwercman, A., Keiding, N., and Skakkebaek, N. E. (1992). Evidence for decreasing quality of semen during the past 50 years. BMJ 305, 609–613.
CrossRef | CAS | PubMed |

Carlsen, E., Giwercman, A., Keiding, N., and Skakkebaek, N. E. (1995). Declining semen quality and increasing incidence of testicular cancer: is there a common cause? Environ. Health Perspect. 103, 137–139.
CrossRef | PubMed |

Chamarro, E., Marco, A., and Esplugas, S. (2001). Use of Fenton reagent to improve organic chemical biodegradability. Water Res. 35, 1047–1051.
CrossRef | CAS | PubMed |

Chang, S., Wait, D. T., Schafer, A. I., and Fane, A. G. (2003). Adsorption of the endocrine-active compound estrone on micro-filtration hollow fiber membranes. Environ. Sci. Technol. 37, 3158–3163.
CrossRef | CAS | PubMed |

Chitra, K. C., Latchoumycandane, C., and Mathur, P. P. (2003). Induction of oxidative stress by bisphenol A in the epididymal sperm of rats. Toxicology 185, 119–127.
CrossRef | CAS | PubMed |

Choy, C. M. Y., Lam, C. W. K., Cheung, L. T. F., Briton-Jones, C. M., Cheung, L. P., and Haines, C. J. (2003). Infertility, blood mercury concentrations and dietary seafood consumption: a case-control study. Obstet. Gynecol. Surv. 58, 325–326.
CrossRef |

Choi, S. M., Yoo, S. D., and Lee, B. M. (2004). Toxicological characteristics of endocrine-disrupting chemicals: developmental toxicity, carcinogenicity, and mutagenicity. J. Toxicol. Environ. Health B Crit. Rev. 7, 1–24..
| CAS | PubMed |

Cincinelli, A., Stortini, A. M., Checchini, L., Martellini, T., Del Bubba, M., and Lepri, L. (2005). Enrichment of organic pollutants in the sea surface microlayer (SML) at Terra Nova Bay, Antarctica: influence of SML on superficial snow composition. J. Environ. Monit. 7, 1305–1312.
CrossRef | CAS | PubMed |

Clarkson, T. W. (2002). The three modern faces of mercury. Environ. Health Perspect. 110, 11–23..
| CAS | PubMed |

Colburn T., and Clement C. (1992). ‘Chemically Induced Alterations in Sexual and Functional Development: The Wildlife/Human Connection. Advances in Modern Environmental Toxicology, vol. 12.’ (Princeton Scientific Publishing: Princeton, NJ.)

Dargnat, C., Teil, M. J., Chevreuil, M., and Blanchard, M. (2009). Phthalate removal throughout wastewater treatment plant. Case study of Marne Aval station (France). Sci. Total Environ. 407, 1235–1244.
CrossRef | CAS | PubMed |

Davis, D. L., Bradlow, H. L., Wolff, M., Woodruff, T., Howl, D. G., and Anton-Culver, H. (1993). Medical hypothesis: xenoestrogens as preventable causes of breast cancer. Environ. Health Perspect. 101, 372–377.
CrossRef | CAS | PubMed |

Davis, B. J., Price, H. C., O’Connor, R. W., Fernando, R., Rowland, A. S., and Morgan, D. L. (2001). Mercury vapor and female reproductive toxicity. Toxicol. Sci. 59, 291–296.
CrossRef | CAS | PubMed |

Daxenberger, A. A. (2002). Pollutants with androgen-disrupting potency. Eur. J. Lipid Sci. Technol. 104, 124–130.
CrossRef | CAS |

Drewes, J. E., Hemming, J., Ladenburger, S. J., Schauer, J., and Sonzogni, W. (2005). An assessment of endocrine disrupting activity changes during wastewater treatment through the use of bioassays and chemical measurements. Water Environ. Res. 77, 12–23.
CrossRef | CAS | PubMed |

Egeland, G. M., Sweeney, M. H., Fingerhut, M. A., Wille, K. K., Schnorr, T. M., and Halperin, W. E. (1994). Total serum testosterone and gonadotropins in workers exposed to dioxin. Am. J. Epidemiol. 139, 272–281..
| CAS | PubMed |

Ernst, E., and Lauritsen, J. G. (1991). Effect of organic and inorganic mercury on human sperm motility. Pharmacol. Toxicol. 68, 440–444.
CrossRef | CAS | PubMed |

Esplugas, S., Bila, D. M., Krause, L. G. T., and Dezotti, M. (2007). Ozonation and advanced oxidation technologies to remove endocrine disrupting chemicals (EDCs) and pharmaceuticals and personal care products (PPCPs) in water effluents. J. Hazard. Mater. 149, 631–642.
CrossRef | CAS | PubMed |

Faqi, A. S., Dalsenter, P. R., Merker, H. J., and Chahoud, I. (1998). Reproductive toxicity and tissue concentrations of low doses of 2,3,7,8-tetrachlorodibenzo-p-dioxin in male offspring rats exposed throughout pregnancy and lactation. Toxicol. Appl. Pharmacol. 150, 383–392.
CrossRef | CAS | PubMed |

Finizio, A., Vighi, M., and Sandroni, D. (1997). Determination of n-octanol/water partition coefficient (Kow) of pesticide. Chemosphere 34, 131–161.
CrossRef | CAS |

Fisher, B. E. (1999). Most unwanted. Environ. Health Perspect. 107, 18–23..

Fisher, J. S. (2004). Environmental anti-androgens and male reproductive health: focus on phthalates and testicular dysgenesis syndrome. Reproduction 127, 305–315.
CrossRef | CAS | PubMed |

Fisher, J. S., Macpherson, S., Marchetti, N., and Sharpe, R. M. (2003). Human ‘testicular dysgenesis syndrome’: a possible model using in utero exposure of the rat to dibutyl phthalate. Hum. Reprod. 18, 1383–1394.
CrossRef | CAS | PubMed |

Fukushima, M., and Tatsumi, K. (2001). Degradation of pentachlorophenol by photo-Fenton systems in the presence of iron(III), humic acid, and hydrogen peroxide. Environ. Sci. Technol. 35, 1771–1778.
CrossRef | CAS | PubMed |

Garcia-Sanchez, A., Antona, J. F., and Urrutia, M. (1992). Geochemical prospection of cadmium in a high incidence area of prostate cancer, Sierra de Gata, Salamanca, Spain. Sci. Total Environ. 116, 243–251.
CrossRef | CAS | PubMed |

Gardella, J. R., and Hill, J. A. (2000). Environmental toxins associated with recurrent pregnancy loss. Semin. Reprod. Med. 18, 407–424.
CrossRef | CAS | PubMed |

Garry, V. F. (2004). Pesticides and children. Toxicol. Appl. Pharmacol. 198, 152–163.
CrossRef | CAS | PubMed |

Gilpin R. K., Wagel D. J., and Solch J. G. (2003). Production, distribution, and fate of polychlorinated dibenzo-p-dioxins, dibenzofurans, and related organohalogens in the environment. In ‘Dioxins and Health’, 2nd edn. (Eds A. Schecter and T. A. Gasiewicz.) pp. 89–136. (Wiley: Hoboken, NJ.)

Giusti, R. M., Iwamoto, K., and Hatch, E. E. (1995). Diethylstilbestrol revisited: a review of the long-term health effects. Ann. Intern. Med. 122, 778–788..
| CAS | PubMed |

Giwercman, A., Carlsen, E., Keiding, N., and Skakkebaek, N. E. (1993). Evidence for increasing incidence of abnormalities of the human testis: a review. Environ. Health Perspect. 101, 65–71.
CrossRef | PubMed |

Goad, R. T., Goad, J. T., Atieh, B. H., and Gupta, R. C. (2004). Carbofuran-induced endocrine disruption in adult male rats. Toxicol. Mech. Methods 14, 233–239.
CrossRef | CAS | PubMed |

Goldman, L., Falk, H., Landrigan, P. J., Balk, S. J., Reigart, R., and Etzel, R. A. (2004). Environmental pediatrics and its impact on government health policy. Pediatrics 113, 1146–1157..
| PubMed |

Gray, L. E., Wolf, C., Lambright, C., Mann, P., Price, M., Cooper, R. L., and Ostby, J. (1999). Administration of potentially antiandrogenic pesticides (procymidone, linuron, iprodione, chlozolinate, p,p′-DDE, and ketoconazole) and toxic substances (dibutyl- and diethylhexyl phthalate, PCB 169, and ethane dimethane sulphonate) during sexual differentiation produces diverse profiles of reproductive malformations in the male rat. Toxicol. Ind. Health 15, 94–118.
CrossRef | PubMed |

Grova, N., Feidt, C., Crépineau, C., Laurent, C., Lafargue, P. E., Hachimi, A., and Rychen, G. (2002). Detection of polycyclic aromatic hydrocarbon levels in milk collected near potential contamination sources. J. Agric. Food Chem. 50, 4640–4642.
CrossRef | CAS | PubMed |

Gültekin, I., and Ince, N. H. (2007). Synthetic endocrine disruptors in the environment and water remediation by advanced oxidation processes. J. Environ. Manage. 85, 816–832.
CrossRef | PubMed |

Gwinn, M. R., Whipkey, D. L., Tennant, L. B., and Weston, A. (2005). Differential gene expression in normal human mammary epithelial cells treated with malathion monitored by DNA microarrays. Environ. Health Perspect. 113, 1046–1051.
CrossRef | CAS | PubMed |

Haddow, A., Roe, F. J. C., Dukes, C. E., and Mitchley, B. C. V. (1964). Cadmium neoplasia: sarcomata at the site of injection of cadmium sulphate in rats and mice. Br. J. Cancer 18, 667–673..
| CAS | PubMed |

Hamm, U., Oller, H.-J., and Kuwan, K. (2005a). Endokrine Substanzen in Abwassern der Papierindustrie. IPW 1, 45–48..

Hamm, U., Oller, H.-J., and Kuwan, K. (2005b). Endokrine Substanzen in Abwassern der Papierindustrie (II). IPW 2, 47–49..

Hardell, L., Van Bavel, B., Lindström, G., Eriksson, M., and Carlberg, M. (2006). In utero exposure to persistent organic pollutants in relation to testicular cancer risk. Int. J. Androl. 29, 228–234.
CrossRef | CAS | PubMed |

Harris, C. A., Henttu, P., Parker, M. G., and Sumpter, J. P. (1997). The estrogenic activity of phthalate esters in vitro. Environ. Health Perspect. 105, 802–811.
CrossRef | CAS | PubMed |

Hayes, T. B., Collins, A., Lee, M., Mendoza, M., Noriega, N., Stuart, A., and Vonk, A. (2002). Hermaphroditic, demasculinized frogs after exposure to the herbicide atrazine at low ecologically relevant doses. Proc. Natl Acad. Sci. USA 99, 5476–5480.
CrossRef | CAS |

Hayes, T. B., Hoang, A., Haeffele, C., Haston, K., Tsui, M., and Vonk, A. (2003). Atrazine-induced hermaphroditism at 0.1 ppb in American leopard frogs (Rana pipiens): laboratory and field evidence. Environ. Health Perspect. 111, 568–575.
CrossRef | CAS | PubMed |

Homma-Takeda, S., Kugenuma, Y., Iwamuro, T., Kumagai, Y., and Shimojo, N. (2001). Impairment of spermatogenesis in rats by methyl mercury: involvement of stage- and cell-specific germ cell apoptosis. Toxicology 169, 25–35.
CrossRef | CAS | PubMed |

Integrated Risk Information System (IRIS) (2005). ‘Environmental Protection Agency. Polychlorinated Biphenyls (PCBs). Last Updated: 23rd January 2008.’ Available at http://www.epa.gov/iris/subst/0294.htm [Verified 24 November 2010].

International Agency for Research on Cancer (IARC) (1983). Polynuclear aromatic compounds, Part 1, chemical, environmental and experimental data. In ‘Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans’, vol. 32. pp. 1–447. (IARC: Lyon.)

International Agency for Research on Cancer (IARC) (1998). ‘Polychlorinated Biphenyls, vol. 18, 1978, p. 43. Last Updated: 27th March 1998.’ Available at http://monographs.iarc.fr/ENG/Monographs/vol18/volume18.pdf [Verified 24 November 2010].

Ishihara, A., Nishiyama, N., Sugiyama, S., and Yamauchi, K. (2003). The effect of endocrine disrupting chemicals on thyroid hormone binding to Japanese quail transthyretin and thyroid hormone receptor. Gen. Comp. Endocrinol. 134, 36–43.
CrossRef | CAS | PubMed |

Järup, L. (2003). Hazards of heavy metal contamination. Br. Med. Bull. 68, 167–182.
CrossRef | PubMed |

Jeong, S. H., Kim, B. Y., Kang, H. G., Ku, H. K., and Cho, J. H. (2006). Effect of chlorpyrifos-methyl on steroid and thyroid hormones in rat F0- and F1-generations. Toxicology 220, 189–202.
CrossRef | CAS | PubMed |

Jiang, K., Li, L. J., Chen, Y. D., and Jin, J. (1997). Determination of PCDD/Fs and dioxin-like PCBs in Chinese commercial PCBs and emissions from a testing PCB incinerator. Chemosphere 34, 941–950.
CrossRef | CAS |

Jobling, S., Sheahan, D., Osborne, J. A., Matthissen, P., and Sumpter, J. P. (1996). Inhibition of testicular growth in rainbow trout (Oncorhynchus mykiss) exposed to estrogenic alkylphenolic chemicals. Environ. Toxicol. Chem. 15, 194–202..
| CAS |

Johansson, M., Nilsson, S., and Lund, B. O. (1998). Interactions between methylsulfonyl PCBs and the glucocorticoid receptor. Environ. Health Perspect. 106, 769–772.
CrossRef | CAS | PubMed |

Kang, H. G., Jeong, S. H., Cho, J. H., Kim, D. G., Park, J. M., and Cho, M. H. (2004). Chlropyrifos-methyl shows anti-androgenic activity without estrogenic activity in rats. Toxicology 199, 219–230.
CrossRef | CAS | PubMed |

Katsumata, H., Kawabe, S., Kaneco, S., Suzuki, T., and Ohta, K. (2004). Degradation of bisphenol A in water by the photo-Fenton reaction. J. Photochem. Photobiol. Chem. 162, 297–305.
CrossRef | CAS |

Kawauchi, H., Suzuki, K., Yamazaki, T., Moriyama, S., Nozaki, M., Yamaguchi, K., Takahashi, A., Youson, J., and Sower, S. A. (2002). Identification of growth hormone in the sea lamprey, an extant representative of a group of the most ancient vertebrates. Endocrinology 143, 4916–4921.
CrossRef | CAS | PubMed |

Kelce, W. R., and Wilson, E. M. (1997). Environmental anti-androgens: developmental effects, molecular mechanisms and clinical implications. J. Mol. Med. 75, 198–207.
CrossRef | CAS | PubMed |

Kester, M. H. A., Bulduk, S., Tibboel, D., Meinl, W., Glatt, H., Falany, C. N., Coughtrie, M. W. H., Bergman, A., Safe, S. H., Kuiper, G., Schuur, A. G., Brouwer, A., and Visser, T. J. (2000). Potent inhibition of estrogen sulfotransferase by hydroxylated PCB metabolites: a novel pathway explaining the estrogenic activity of PCBs. Endocrinology 141, 1897–1900.
CrossRef | CAS | PubMed |

Kim, I. Y., Shin, J. H., Kim, H. S., Lee, S. J., Kang, I. H., Kim, T. S., Moon, H. J., Choi, K. S., Moon, A., and Han, S. Y. (2004). Assessing estrogenic activity of pyrethroid insecticides using in vitro combination assays. J. Reprod. Dev. 50, 245–255.
CrossRef | CAS | PubMed |

Kolonel, L. N. (1996). Nutrition and prostate cancer. Cancer Causes Control 7, 83–94.
CrossRef | CAS | PubMed |

Kuiper, G. G. J. M., Enmark, E., Pelto-Huikko, M., Nilsson, S., and Gustafsson, J. Å. (1996). Cloning of a novel estrogen receptor expressed in rat prostate and ovary. Proc. Natl. Acad. Sci. USA 93, 5925–5930..
| CAS |

Kuiper, G. G. J. M., Carlsson, B., Grandien, K., Enmark, E., Häggblad, J., Nilsson, S., and Gustafsson, J. Å. (1997). Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors α and β. Endocrinology 138, 863–870..
| CAS | PubMed |

Kulbat, E., Olańczuk-Neyman, K., Quant, B., Geneja, M., and Haustein, E. (2003). Heavy metals removal in the mechanical–biological wastewater treatment plant ‘Wschód’ in Gdańs. Pol. J. Environ. Stud. 12, 635–641..
| CAS |

Lemaire, G., Terouanne, B., Mauvais, P., Michel, S., and Rahmani, R. (2004). Effect of organochlorine pesticides on human androgen receptor activation in vitro. Toxicol. Appl. Pharmacol. 196, 235–246.
CrossRef | CAS | PubMed |

Li, M. H., and Hansen, L. G. (1997). Consideration of enzyme and endocrine interactions in the risk assessment of PCBs. Rev. Toxicol. 1, 71–156..
| CAS |

Li, C. T., Lin, Y. C., Lee, W. J., and Tsai, P. J. (2003). Emission of polycyclic aromatic hydrocarbons and their carcinogenic potencies from cooking sources to the urban atmosphere. Environ. Health Perspect. 111, 483–487.
CrossRef | CAS | PubMed |

Liu, Z. H., Kanjo, Y., and Mizutani, S. (2009). Removal mechanisms for endocrine disrupting compounds (EDCs) in wastewater treatment: physical means, biodegradation, and chemical advanced oxidation: a review. Sci. Total Environ. 407, 731–748.
CrossRef | CAS | PubMed |

Loganathan, B., and Kannan, K. (1994). Global organochlorine contamination trends: an overview. Ambio 23, 187–189..

Lu, S. Y., Liao, J. W., Kuo, M. L., Wang, S. C., Hwang, J. S., and Ueng, T. H. (2004). Endocrine-disrupting activity in carbendazim-induced reproductive and developmental toxicity in rats. J. Toxicol. Environ. Health A 67, 1501–1515.
CrossRef | CAS | PubMed |

Mabilia, R., Cecinato, A., Tomasi Scianò, M. C., Di Palo, V., and Possanzini, M. (2004). Characterization of polycyclic aromatic hydrocarbons and carbonyl compounds in diesel exhaust emissions. Ann. Chim. 94, 733–740.
CrossRef | CAS | PubMed |

Mackenzie, C. A., and Constanze, A. (2005). Declining sex ratio in a first nation community. Environ. Health Perspect. 113, 1295–1298.
CrossRef | CAS | PubMed |

Malato, S., Caceras, J., Aguera, A., Mezcua, M., Hernando, D., Vial, J., and Fernandez-Alba, A. R. (2001). Degradation of imidacloprid in water by photo-Fenton and TiO2 photocatalysis at a solar pilot plant: a comparative study. Environ. Sci. Technol. 35, 4359–4366.
CrossRef | CAS | PubMed |

Malato, S., Blanco, J., Cáceres, J., Fernández-Alba, A. R., Agüera, A., and Rod?ýguez, A. (2002). Photocatalytic treatment of water-soluble pesticides by photo-Fenton and TiO2 using solar energy. Catal. Today 76, 209–220.
CrossRef | CAS |

Mankame, T., Hokanson, R., Chowdhary, R., and Busbee, D. (2004). Altered gene expression in human cells induced by the agricultural chemical Enable. Toxicol. Ind. Health 20, 89–102.
CrossRef | CAS | PubMed |

Markey, C. M., Luque, E. H., Munoz de Toro, M., Sonnenschein, C., and Soto, A. M. (2001). In utero exposure to bisphenol A alters the development and tissue organization of the mouse mammary gland. Biol. Reprod. 65, 1215–1223..
| CAS | PubMed |

Mascolo, G., Ciannarella, R., Balest, L., and Lopez, A. (2008). Effectiveness of UV-based advanced oxidation processes for the remediation of hydrocarbon pollution in the groundwater: a laboratory investigation. J. Hazard. Mater. 152, 1138–1145.
CrossRef | CAS | PubMed |

Mathur, V., Bhatnagar, P., Sharma, R. G., Acharya, V., and Sexana, R. (2002). Breast cancer incidence and exposure to pesticides among women originating from Jaipur. Environ. Int. 28, 331–336.
CrossRef | CAS | PubMed |

McIntyre, B. S., Barlow, N. J., and Foster, P. M. D. (2001). Androgen-mediated development in the male rat offspring exposed to flutamide in utero: permanence and correlation of early postnatal changes in anogenital distance and nipple retention with malformations in androgen-dependent tissues. Toxicol. Sci. 62, 236–249.
CrossRef | CAS | PubMed |

McRill, C., Boyer, L. V., Flood, T. J., and Ortega, L. (2000). Mercury toxicity due to use of a cosmetic cream. J. Occup. Environ. Med. 42, 4–7.
CrossRef | CAS | PubMed |

Menchini-Fabris, F., Rossi, P., Palego, P., Simi, S., and Turchi, P. (1996). Declining sperm counts in Italy during the past 20 years. Andrologia 28, 304.
CrossRef | CAS | PubMed |

Mendola, P., Buck, G. M., Sever, L. E., Zielezny, M., and Vena, J. E. (1997). Consumption of PCB-contaminated freshwater fish and shortened menstrual cycle length. Am. J. Epidemiol. 146, 955–960..
| CAS | PubMed |

Metzler M., and Pfeiffer E. (2001). Chemistry of natural and antropogenic endocrine active compounds. In ‘Endocrine Disruptors Part I’. (Ed. M. Metzler.) pp. 63–80. (Springer: Berlin.)

Meulenberg, E. E. (2002). A new test to identify endocrine disruptors using sex hormone-binding globulins from human serum. Eur. J. Lipid Sci. Technol. 104, 131–136.
CrossRef | CAS |

Mocarelli, P., Gerthoux, P. M., Patterson, D. G., Milani, S., Limonta, G., Bertona, M., Signorini, S., Tramacere, P., Colombo, L., Crespi, C., Brambilla, P., Sarto, C., Carreri, V., Sampson, E. J., Turner, W. E., and Needham, L. L. (2008). Dioxin exposure, from infancy through puberty, produces endocrine disruption and affects human semen quality. Environ. Health Perspect. 116, 70–77.
CrossRef | CAS | PubMed |

Morinaga, H., Yanase, T., Nomura, M., Okabe, T., Goto, K., Harada, N., and Nawata, H. (2004). A benzimidazole fungicide, benomyl, and its metabolite, carbendazim, induce aromatase activity in a human ovarian granulose-like tumor cell line (KGN). Endocrinology 145, 1860–1869.
CrossRef | CAS | PubMed |

Muir, D., Braune, B., DeMarch, B., Norstrom, R., Wagemann, R., Lockhart, L., Hargrave, B., Bright, D., Addison, R., Payne, J., and Reimer, K. (1999). Spatial and temporal trends and effects of contaminants in the Canadian Artic marine ecosystem: a review. Sci. Total Environ. 230, 83–144.
CrossRef | CAS | PubMed |

Mukherjee, A., Sengupta, M. K., Hossain, M. A., Ahamed, S., Das, B., Nayak, B., Lodh, D., Rahman, M. M., and Chakraborti, D. (2006). Arsenic contamination in groundwater: a global perspective with emphasis on the Asian scenario. J. Health Popul. Nutr. 24, 142–163..
| PubMed |

Muñoz de Toro, M., Markey, C. M., Wadia, P. R., Luque, E. H., Rubin, B. S., Sonnenschein, C., and Soto, A. M. (2005). Perinatal exposure to bisphenol A alters peripubertal mammary gland development in mice. Endocrinology 146, 4138–4147.
CrossRef | PubMed |

Mylchreest, E., Cattley, R. C., and Foster, P. M. D. (1998). Male reproductive tract malformations in rats following gestational and lactational exposure to di(n-butyl) phthalate: an antiandrogenic mechanism? Toxicol. Sci. 43, 47–60..
| CAS | PubMed |

Mylchreest, E., Sar, M., Cattley, R. C., and Foster, P. M. D. (1999). Disruption of androgen-regulated male reproductive development by di(n-butyl) phthalate during late gestation in rats is different from flutamide. Toxicol. Appl. Pharmacol. 156, 81–95.
CrossRef | CAS | PubMed |

Nadal, M., Schuhmacher, M., and Domingo, J. L. (2004). Levels of PAHs in soil and vegetation samples from Tarragona County, Spain. Environ. Pollut. 132, 1–11.
CrossRef | CAS | PubMed |

Nampoothiri, L. P., and Gupta, S. (2006). Simultaneous effect of lead and cadmium on granulosa cells: a cellular model for ovarian toxicity. Reprod. Toxicol. 21, 179–185.
CrossRef | CAS | PubMed |

Nicolopoulou-Stamati, P., and Pitsos, M. A. (2001). The impact of endocrine disrupters on the female reproductive system. Hum. Reprod. Update 7, 323–330.
CrossRef | CAS | PubMed |

Nimrod, A. C., and Benson, W. H. (1996). Environmental estrogenic effects of alkylphenol ethoxylates. Crit. Rev. Toxicol. 26, 335–364.
CrossRef | CAS | PubMed |

Nogueira, R. F. P., Silva, M. R. A., and Trovó, A. G. (2005). Influence of the iron source on the solar photo-Fenton degradation of different classes of organic compounds. Sol. Energy 79, 384–392.
CrossRef | CAS |

Nordström, S., Beckman, L., and Nordenson, I. (1979). Occupational and environmental risks in and around a smelter in northern Sweden. V. Spontaneous abortion among female employees and decreased birth weight in their offspring. Hereditas 90, 291–296.
CrossRef | PubMed |

Olie, K., Vermeulen, P. L., and Hutzinger, O. (1977). Chlorodibenzo-p-dioxins and chlorodibenzofurans are trace components of fly ash and flue gas of some municipal incinerators in the Netherlands. Chemosphere 6, 455–459.
CrossRef | CAS |

Parks, L. G., Ostby, J. S., Lambright, C. R., Abbott, B. D., Klinefelter, G. R., Barlow, N. J., and Earl Gray, L. (2000). The plasticizer diethylhexyl phthalate induces malformations by decreasing fetal testosterone synthesis during sexual differentiation in the male rat. Toxicol. Sci. 58, 339–349.
CrossRef | CAS | PubMed |

Perera, F., Hemminke, K., Jedrychowski, W., Whyatt, R., Campbell, U., Hsu, Y., Santella, R., Albertini, R., and O’Neill, J. P. (2002). In utero DNA damage from environmental pollution is associated with somatic gene mutation in newborns. Cancer Epidemiol. Biomarkers Prev. 11, 1134–1137..
| CAS | PubMed |

Perera, F. P., Tang, D., Rauh, V., Lester, K., Tsai, W. Y., Tu, Y. H., Weiss, L., Hoepner, L., King, J., Del Priore, G., and Lederman, S. A. (2005). Relationships among polycyclic aromatic hydrocarbons: DNA adducts, proximity to the World Trade Center, and effects on fetal growth. Environ. Health Perspect. 113, 1062–1067.
CrossRef | CAS | PubMed |

Peterson, R. E., Theobald, H. M., and Kimmel, G. L. (1993). Developmental and reproductive toxicity of dioxins and related compounds: cross-species comparisons. Crit. Rev. Toxicol. 23, 283–335.
CrossRef | CAS | PubMed |

Petrovic, M., Eljarrate, E., Lopez De Alda, M. J., and Barcelo, D. (2004). Endocrine disrupting compounds and other emerging contaminants in the environment: a survey on new monitoring strategies and occurrence data. Anal. Bioanal. Chem. 378, 549–562.
CrossRef | CAS | PubMed |

Pokhrel, D., and Viraraghavan, T. (2004). Treatment of pulp and paper mill effluent: a review. Sci. Total Environ. 333, 37–58.
CrossRef | CAS | PubMed |

Przyrembel, H., Heinrich-Hirsch, B., and Vieth, B. (2000). Exposition to and health effects of residues in human milk. Adv. Exp. Med. Biol. 478, 307–325.
CrossRef | CAS | PubMed |

Pulgar, R., Olea-Serrano, M. F., Novillo-Fertrell, A., Rivas, A., Pazos, P., Pedraza, V., Navajas, J. M., and Olea, N. (2000). Determination of bisphenol A and related aromatic compounds released from bis-GMA-based composites and sealants by high performance liquid chromatography. Environ. Health Perspect. 108, 21–27.
CrossRef | CAS | PubMed |

Rai U. N., and Pal A. (2002). ‘Health Hazards of Heavy Metals.’ Available at http://isebindia.com/01_04/02-01-2.html [Verified 24 November 2010].

Roman B. L., and Peterson R. E. (1998). Developmental male reproductive toxicology of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and PCBs. In ‘Reproductive and Developmental Toxicology’. (Ed. K. S. Korach.) pp. 593–624. (Marcel Dekker: New York.)

Ross, G. (2004). The public health implications of polychlorinated biphenyls (PCBs) in the environment. Ecotoxicol. Environ. Saf. 59, 275–291.
CrossRef | CAS | PubMed |

Rubin, B. S., and Soto, A. M. (2009). Bisphenol A: perinatal exposure and body weight. Mol. Cell. Endocrinol. 304, 55–62.
CrossRef | CAS | PubMed |

Santodonato, J. (1997). Review of the estrogenic and antiestrogenic activity of polycyclic aromatic hydrocarbons: relationship to carcinogenicity. Chemosphere 34, 835–848.
CrossRef | CAS | PubMed |

Satarug, S., and Moore, M. R. (2004). Adverse health effects of chronic exposure to low-level cadmium in foodstuffs and cigarette smoke. Environ. Health Perspect. 112, 1099–1103.
CrossRef | CAS | PubMed |

Satoh, H. (2003). Behavioral teratology of mercury and its compounds. Tohoku J. Exp. Med. 201, 1–9.
CrossRef | CAS | PubMed |

Schantz, S. L., and Widholm, J. J. (2001). Cognitive effects of endocrine-disrupting chemicals in animals. Environ. Health Perspect. 109, 1197–1206.
CrossRef | CAS | PubMed |

Schönfelder, G., Wittfoht, W., Hopp, H., Talsness, C. E., Paul, M., and Chahoud, I. (2002). Parent bisphenol A accumulation in the human maternal–fetal–placental unit. Environ. Health Perspect. 110, A703–A707.
CrossRef | PubMed |

Schreinemachers, D. M. (2003). Birth malformations and other adverse perinatal outcomes in four US wheat-producing states. Environ. Health Perspect. 111, 1259–1264.
CrossRef | CAS | PubMed |

Schuurs, A. H. B. (1999). Reproductive toxicity of occupational mercury. A review of the literature. J. Dent. 27, 249–256.
CrossRef | CAS | PubMed |

Scippo, M.-L. (2004). Recombinant human estrogen, androgen and progesterone receptors for detection of potential endocrine disruptors. Anal. Bioanal. Chem. 378, 664–669.
CrossRef | CAS | PubMed |

Sharara, F. I., Seifer, D. B., and Flaws, J. A. (1998). Environmental toxicants and female reproduction. Fertil. Steril. 70, 613–622.
CrossRef | CAS | PubMed |

Sharpe, R. M. (2003). ‘The oestrogen hypothesis’: where do we stand now? Int. J. Androl. 26, 2–15.
CrossRef | CAS | PubMed |

Sharpe, R. M. (2006). Pathways of endocrine disruption during male sexual differentiation and masculinisation. Best Pract. Res. Clin. Endocrinol. Metab. 20, 91–110.
CrossRef | CAS | PubMed |

Sharpe, R. M., and Irvine, D. S. (2004). How strong is the evidence of a link between environmental chemicals and adverse effects on human reproductive health? BMJ 328, 447–451.
CrossRef | CAS | PubMed |

Sharpe, R. M., and Skakkebaek, N. E. (1993). Are estrogens involved in falling sperm counts and disorders of the male reproductive tract? Lancet 341, 1392–1396.
CrossRef | CAS | PubMed |

Shen W., Chen Y., Li C., and Ji Q. (2000). Effect of mercury chloride on the reproductive function and visceral organ of female mouse. Wei Sheng Yan Jiu 29, 75–77. [In Chinese] 12725078

Shultz, V. D., Phillips, S., Sar, M., Foster, P. M., and Gaido, K. W. (2001). Altered gene profiles in fetal rat testes after in utero exposure to di(n-butyl) phthalate. Toxicol. Sci. 64, 233–242.
CrossRef | CAS | PubMed |

Silbergeld, E. K. (1991). Lead in bone: implications for toxicology during pregnancy and lactation. Environ. Health Perspect. 91, 63–70.
CrossRef | CAS | PubMed |

Simko, P. (2002). Determination of polycyclic aromatic hydrocarbons in smoked meat products and smoke flavouring food additives. J. Chromatogr. B Anal. Technol. Biomed. Life Sci. 770, 3–18.
CrossRef | CAS |

Simoncini, T., and Genazzani, A. R. (2003). Non-genomic actions of sex steroid hormones. Eur. J. Endocrinol. 148, 281–292.
CrossRef | CAS | PubMed |

Sinawat, S. (2000). The environmental impact on male fertility. J. Med. Assoc. Thai. 83, 880–885..
| CAS | PubMed |

Singer, P. L. (1949). Occupational oligospermia. J. Am. Med. Assoc. 140, 1249.

Siu, E. R., Mruk, D. D., Porto, C. S., and Cheng, C. Y. (2009). Cadmium-induced testicular injury. Toxicol. Appl. Pharmacol. 238, 240–249.
CrossRef | CAS | PubMed |

Skakkebæk, N. E. (2002). Endocrine disrupters and testicular dysgenesis syndrome. Horm. Res. 57, 43.
CrossRef |

Skakkebæk, N. E., Rajpert-De Meyts, E., and Main, K. M. (2001). Testicular dysgenesis syndrome: an increasingly common developmental disorder with environmental aspects. Hum. Reprod. 16, 972–978.
CrossRef | PubMed |

Smith, A. H., Hopenhayn-Rich, C., Bates, M. N., Goeden, H. M., Hertz-Picciotto, I., Duggan, H. M., Wood, R., Kosnett, M. J., and Smith, M. T. (1992). Cancer risks from arsenic in drinking water. Environ. Health Perspect. 97, 259–267.
CrossRef | CAS | PubMed |

Snyder, S. A., Westerhoff, P., Yoon, Y., and Sedlak, D. L. (2003). Pharmaceuticals, personal care products, and endocrine disruptors in water: Implications for the water industry. Environ. Eng. Sci. 20, 449–469..
| CAS |

Soares, A., Guieysse, B., Jefferson, B., Cartmell, E., and Lester, J.-N. (2008). Nonylphenol in the environment: a critical review on occurrence, fate, toxicity and treatment in wastewaters. Environ. Int. 34, 1033–1049.
CrossRef | CAS | PubMed |

Soto, A. M., Justicia, H., Wray, J. W., and Sonnenschein, C. (1991). p-Nonylphenol: an estrogenic xenobiotic released from ‘modified’ polystrene. Environ. Health Perspect. 92, 167–173.
CrossRef | CAS | PubMed |

Soto, A. M., Chung, K. L., and Sonnenschein, C. (1994). The pesticides endosulfan, toxaphene, and dieldrin have estrogenic effects on human estrogen sensitive cells. Environ. Health Perspect. 102, 380–383.
CrossRef | CAS | PubMed |

Soto, A. M., Sonnenschein, C., Chung, K. L., Fernandez, M. F., Olea, N., and Olea-Serrano, M. F. (1995). The E-SCREEN assay as a tool to identify estrogens: an update on estrogenic environmental pollutants. Environ. Health Perspect. 103, 113–122.
CrossRef | CAS |

Staples, C. A., Dorn, P. B., Klečka, G. M., O’Block, S. T., and Harris, L. R. (1998). A review of the environmental fate, effects, and exposures of bisphenol A. Chemosphere 36, 2149–2173.
CrossRef | CAS | PubMed |

Stillman, R. J. (1982). In utero exposure to diethylstilbestrol: adverse effects on the reproductive tract and reproductive performance and male and female offspring. Am. J. Obstet. Gynecol. 142, 905–921..
| CAS | PubMed |

Storrs, S. I., and Kiesecker, J. M. (2004). Survivorship patterns of larval amphibians exposed to low concentrations of atrazine. Environ. Health Perspect. 112, 1054–1057.
CrossRef | CAS | PubMed |

Sultan, C., Balaguer, P., Terouanne, B., Georget, V., Paris, F., Jeandel, C., Lumbroso, S., and Nicolas, J. C. (2001). Environmental xenoestrogens, antiandrogens and disorders of male sexual differentiation. Mol. Cell. Endocrinol. 178, 99–105.
CrossRef | CAS | PubMed |

Swan, S. H., Elkin, E. P., and Fenster, L. (2000). The question of declining sperm density revisited: an analysis of 101 studies published 1934–1996. Environ. Health Perspect. 108, 961–966.
CrossRef | CAS | PubMed |

Tang, H. W., Huel, G., Campagna, D., Hellier, G., Boissinot, C., and Blot, P. (1999). Neurodevelopmental evaluation of 9-month-old infants exposed to low levels of lead in utero: involvement of monoamine neurotransmitters. J. Appl. Toxicol. 19, 167–172.
CrossRef | CAS | PubMed |

Tao, S., Cui, Y. H., Xu, F. L., Li, B. G., Cao, J., Liu, W. X., Schmitt, G., Wang, X. J., Shen, W. R., Qing, B. P., and Sun, R. (2004). Polycyclic aromatic hydrocarbons (PAHs) in agricultural soil and vegetables from Tianjin. Sci. Total Environ. 320, 11–24.
CrossRef | CAS | PubMed |

Tapio, S., and Grosche, B. (2006). Arsenic in the aetiology of cancer. Mutat. Res. 612, 215–246.
CrossRef | CAS | PubMed |

The European Parliament and the Council of the European Union (2000). Directive 2000/60/EC of the European Parliament and of the Council of 23 October 2000 establishing a framework for community action in the field of water policy. Off. J. Eur. Communities 327, 1–73. Available at http://eur-lex.europa.eu/LexUriServ/LexUriServ.do?uri=OJ:L:2000:327:0001:0072:EN:PDF

The European Parliament and the Council of the European Union (2008). Directive 2008/105/EC of the European Parliament and of the Council of 16 December 2008, on environmental quality standards in the field of water policy, amending and subsequently repealing Council Directives 82/176/EEC, 83/513/EEC, 84/156/EEC, 84/491/EEC, 86/280/EEC and amending Directive 2000/60/EC of the European Parliament and of the Council. Off. J. Eur. Communities 384, 84–97. Available at http://eur-lex.europa.eu/LexUriServ/LexUriServ.do?uri=OJ:L:2008:348:0084:0097:EN:PDF

Theobald H. M., Kimmel G. L., and Peterson R. E. (2003). Developmental and reproductive toxicity of dioxins and related compounds. In ‘Dioxins and Health’, 2nd edn. (Eds A. Schecter and T. A. Gasiewicz.) pp. 329–431. (John Wiley and Sons: Hoboken, NJ.)

Thomas, J. A., and Thomas, M. J. (1984). Biological effects of di-(2-ethyl-hexyl) phthalate and other phthalic acid esters. Crit. Rev. Toxicol. 13, 283–317.
CrossRef | CAS | PubMed |

Thompson, C. J., Ross, S. M., and Gaido, K. W. (2004). Di(n-butyl) phthalate impairs cholesterol transport and steroidogenesis in the fetal rat testis through a rapid and reversible mechanism. Endocrinology 145, 1227–1237.
CrossRef | CAS | PubMed |

Thompson, G., Swain, J., Kay, M., and Forster, C. F. (2001). The treatment of pulp and paper mill effluent: a review. Bioresour. Technol. 77, 275–286.
CrossRef | CAS | PubMed |

Tilson, H. A. (1998). Developmental neurotoxicology of endocrine disruptors and pesticides: identification of information gaps and research needs. Environ. Health Perspect. 106, 807–811.
CrossRef |

Tong, S., and McMichael, A. J. (1999). The magnitude, persistence and public health significance of cognitive effects of environmental lead exposure in childhood. J. Environ. Med. 1, 103–110.
CrossRef |

Toppari, J., Larsen, J. C., Christiansen, P., Giwercman, A., Grandjean, P., Guillette, L. J., Jégou, B., Jensen, T. K., Jouannet, P., Keiding, N., Leffers, H., McLachlan, J. A., Meyer, O., Müller, J., Rajpert-de Meyts, E., Scheike, T., Sharpe, R., Sumpter, J., and Skakkebaek, N. E. (1996). Male reproductive health and environmental xenoestrogens. Environ. Health Perspect. 104, 741–803.
CrossRef | CAS | PubMed |

Truss, M., and Beato, M. (1993). Steroid hormone receptors: interaction with deoxyribonucleic acid and transcription factors. Endocr. Rev. 14, 459–479..
| CAS | PubMed |

Tsapakis, M., and Stephanou, E. G. (2005). Occurrence of gaseous and particulate polycyclic aromatic hydrocarbons in the urban atmosphere: study of sources and ambient temperature effect on the gas/particle concentration and distribution. Environ. Pollut. 133, 147–156.
CrossRef | CAS | PubMed |

US Environmental Protection Agency (1984). ‘Health Effect Assessment for Polycyclic Aromatic Hydrocarbon (PAH). EPA 540/1–86–013.’ (Environmental Criteria and Assessment Office: Cincinnati, OH.)

Vasseur, P., and Cossu-Leguille, C. (2006). Linking molecular interactions to consequent effects of persistent organic pollutants (POPs) upon populations. Chemosphere 62, 1033–1042.
CrossRef | CAS | PubMed |

Vethaak, A. D., Lahr, J., Schrap, S. M., Belfroid, A. C., Rijs, G. B. J., Gerritsen, A., de Boer, J., Bulder, A. S., Grinwis, G. C., Kuiper, R. V., Legler, J., Murk, T. A., Peijnenburg, W., Verhaar, H. J., and de Voogt, P. (2005). An integrated assessment of estrogenic contamination and biological effects in the aquatic environment of The Netherlands. Chemosphere 59, 511–524.
CrossRef | CAS | PubMed |

Vidal, G., and Diez, M. C. (2005). Methanogenic toxicity of wood processing effluents. J. Environ. Manage. 74, 317–325.
CrossRef | CAS | PubMed |

Vinceti, M., Venturelli, M., Sighinolfi, C., Trerotoli, P., Bonvicini, F., Ferrari, A., Bianchi, G., Serio, G., Bergomi, M., and Vivoli, G. (2007). Case-control study of toenail cadmium and prostate cancer risk in Italy. Sci. Total Environ. 373, 77–81.
CrossRef | CAS | PubMed |

Waliszewski, S. M., Aguirre, A. A., Infanzón, R. M., and Siliceo, J. (2000). Carry-over of persistent organochlorine pesticides through placenta to fetus. Salud Publica Mex. 42, 384–390.
CrossRef | CAS | PubMed |

Walter, B. A., Agha, B. J., and Digenis, G. A. (1988). Disposition of [14C]nonoxynol-9 after intravenous or vaginal administration to female Sprague-Dawley rats. Toxicol. Appl. Pharmacol. 96, 258–268.
CrossRef | CAS | PubMed |

Watanabe, C., Inaoka, T., Matsui, T., Ishigaki, K., Murayama, N., and Ohtsuka, R. (2003). Effects of arsenic on younger generations. J. Environ. Sci. Health A Tox. Hazard. Subst. Environ. Eng. 38, 129–139.
CrossRef | PubMed |

Weltje, L., vom Saal, F. S., and Oehlmann, J. (2005). Reproductive stimulation by low doses of xenoestrogens contrasts with the view of hormesis as an adaptive response. Hum. Exp. Toxicol. 24, 431–437.
CrossRef | CAS | PubMed |

White, R., Jobling, S., Hoare, S. A., Sumpter, J. P., and Parker, M. G. (1994). Environmentally persistent alkylphenolic compounds are estrogenic. Endocrinology 135, 175–182.
CrossRef | CAS | PubMed |

Will, I. B. S., Moraes, J. E. F., Teixeira, A. C. S. C., Guardani, R., and Nascimento, C. A. O. (2004). Photo-Fenton degradation of wastewater containing organic compounds in solar reactor. Separ. Purif. Tech. 34, 51–57.
CrossRef | CAS |

Wintgens, T., Gallenkemper, M., and Melin, T. (2002). Endocrine disrupter removal from wastewater using membrane bioreactor and nanofiltration technology. Desalination 146, 387–391.
CrossRef | CAS |

World Health Organization (WHO) (1991). ‘Environmental Health Criteria 118: Inorganic Mercury.’ (WHO: Geneva.)

Xu, C., Johnson, J. E., Singh, P. K., Jones, M. M., Yan, H., and Carter, C. E. (1996). In vivo studies of cadmium-induced apoptosis in testicular tissue of the rat and its modulation by a chelating agent. Toxicology 107, 1–8.
CrossRef | CAS | PubMed |

Xu, X. R., Li, S. X., Li, X. Y., Gu, J. D., Chen, F., Li, X. Z., and Li, H. B. (2009). Degradation of n-butyl benzyl phthalate using TiO2/UV. J. Hazard. Mater. 164, 527–532.
CrossRef | CAS | PubMed |

Yoon, Y., Westerhoff, P., Yoon, J., and Snyder, S. A. (2004). Removal of 17β estradiol and fluoranthene by nanofiltration and ultrafiltration. J. Environ. Eng. 130, 1460–1467.
CrossRef | CAS |

Yoon, Y., Westerhoff, P., Snyder, S. A., and Wert, E. C. (2006). Nanofiltration and ultrafiltration of endocrine disrupting compounds, pharmaceuticals and personal care products. J. Membr. Sci. 270, 88–100.
CrossRef | CAS |

Yoshida, M. (2002). Placental to fetal transfer of mercury and fetotoxicity. Tohoku J. Exp. Med. 196, 79–88.
CrossRef | CAS | PubMed |

Zahir, F., Rizwi, S. J., Haq, S. K., and Khan, R. H. (2005). Low dose mercury toxicity and human health. Environ. Toxicol. Pharmacol. 20, 351–360.
CrossRef | CAS |

Zhao, J., Li, Y., Zhang, C., Zeng, Q., and Zhou, Q. (2008). Sorption and degradation of bisphenol A by aerobic activated sludge. J. Hazard. Mater. 155, 305–311.
CrossRef | CAS | PubMed |


   
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