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Article << Previous     |     Next >>   Contents Vol 25(2)

Altered pregnancy outcomes in mice following treatment with the hyperglycaemia mimetic, glucosamine, during the periconception period

Cheryl J. Schelbach A, Rebecca L. Robker A, Brenton D. Bennett A, Ashley D. Gauld A, Jeremy G. Thompson A and Karen L. Kind B C

A The Robinson Institute, The Research Centre for Reproductive Health, School of Paediatrics and Reproductive Health, The University of Adelaide, Adelaide, SA 5005, Australia.
B The Robinson Institute, The Research Centre for Reproductive Health, School of Animal and Veterinary Sciences, The University of Adelaide, Adelaide, SA 5005, Australia.
C Corresponding author. Email: karen.kind@adelaide.edu.au

Reproduction, Fertility and Development 25(2) 405-416 http://dx.doi.org/10.1071/RD11313
Submitted: 16 December 2011  Accepted: 31 March 2012   Published: 21 May 2012


 
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Abstract

Exposure of cumulus–oocyte complexes to the hyperglycaemia mimetic, glucosamine, during in vitro maturation impairs embryo development, potentially through upregulation of the hexosamine biosynthesis pathway. This study examined the effects of in vivo periconception glucosamine exposure on reproductive outcomes in young healthy mice, and further assessed the effects in overweight mice fed a high-fat diet. Eight-week-old mice received daily glucosamine injections (20 or 400 mg kg–1) for 3–6 days before and 1 day after mating (periconception). Outcomes were assessed at Day 18 of gestation. Glucosamine treatment reduced litter size independent of dose. A high-fat diet (21% fat) for 11 weeks before and during pregnancy reduced fetal size. No additional effects of periconception glucosamine (20 mg kg–1) on pregnancy outcomes were observed in fat-fed mice. In 16-week-old mice fed the control diet, glucosamine treatment reduced fetal weight and increased congenital abnormalities, but did not alter litter size. As differing effects of glucosamine were observed in 8-week-old and 16-week-old mice, maternal age effects were assessed. Periconception glucosamine at 8 weeks reduced litter size, whereas glucosamine at 16 weeks reduced fetal size. Thus, in vivo periconception glucosamine exposure perturbs reproductive outcomes in mice, with the nature of the outcomes dependent upon maternal age.

Additional keywords: fetal development, hexosamine biosynthesis pathway.


References

Adebowale, A., Du, J., Liang, Z., Leslie, J. L., and Eddington, N. D. (2002). The bioavailability and pharmacokinetics of glucosamine hydrochloride and low molecular weight chondroitin sulfate after single and multiple doses to beagle dogs. Biopharm. Drug Dispos. 23, 217–225.
CrossRef | CAS | PubMed |

Aghazadeh-Habashi, A., Sattari, S., Pasutto, F., and Jamali, F. (2002). Single dose pharmacokinetics and bioavailability of glucosamine in the rat. J. Pharm. Pharm. Sci. 5, 181–184.
| CAS | PubMed |

Ali, S., and Dornhorst, A. (2011). Diabetes in pregnancy: health risks and management. Postgrad. Med. J. 87, 417–427.
CrossRef | PubMed |

Anderson, J. W., Nicolosi, R. J., and Borzelleca, J. F. (2005). Glucosamine effects in humans: a review of effects on glucose metabolism, side effects, safety considerations and efficacy. Food Chem. Toxicol. 43, 187–201.
CrossRef | CAS | PubMed |

Barrientos, C., Racotta, R., and Quevedo, L. (2010). Glucosamine attenuates increases of intraabdominal fat, serum leptin levels and insulin resistance induced by a high-fat diet in rats. Nutr. Res. 30, 791–800.
CrossRef | CAS | PubMed |

Buse, M. G. (2006). Hexosamines, insulin resistance and the complications of diabetes: current status. Am. J. Physiol. Endocrinol. Metab. 290, E1–E8.
CrossRef | CAS | PubMed |

Buse, M. G., Robinson, K. A., Gettys, T. W., McMahon, E. G., and Gulve, E. A. (1997). Increased activity of the hexosamine synthesis pathway in muscles of insulin-resistant ob/ob mice. Am. J. Physiol. Endocrinol. Metab. 272, E1080–E1088.
| CAS |

Butkinaree, C., Park, K., and Hart, G. W. (2010). O-linked beta-n-acetylglucosamine (O-GlcNAc): extensive crosstalk with phosphorylation to regulate signalling and transcription in response to nutrients and stress. Biochim. Biophys. Acta 1800, 96–106.
CrossRef | CAS | PubMed |

Cardozo, E., Pavone, M. E., and Hirshfeld-Cytron, J. E. (2011). Metabolic syndrome and oocyte quality. Trends Endocrinol. Metab. 22, 103–109.
CrossRef | CAS | PubMed |

Chan, A., Scott, J., Nguyen, A.-M., and Sage, L. (2009). ‘Pregnancy outcome in South Australia 2008’. (Adelaide Pregnancy Outcome Unit, SA Health, Government of South Australia: Adelaide.)

Colagiuri, S., Borch-Johnsen, K., Glumer, C., and Vistisen, D. (2005). There really is an epidemic of Type 2 diabetes. Diabetologia 48, 1459–1463.
CrossRef | CAS | PubMed |

Combs, C. A., and Kitzmiller, J. L. (1991). Spontaneous abortion and congenital malformations in diabetes. Baillieres Clin. Obstet. Gynaecol. 5, 315–331.
CrossRef | CAS | PubMed |

Considine, R. V., Cooksey, R. C., Williams, L. B., Fawcett, R. L., Zhang, P., Ambrosius, W. T., Whitfield, R. M., Jones, R., Inman, M., Huse, J., and McClain, D. A. (2000). Hexosamines regulate leptin production in human subcutaneous adipocytes. J. Clin. Endocrinol. Metab. 85, 3551–3556.
CrossRef | CAS | PubMed |

Cooksey, R. C., and McClain, D. A. (2011). Increased hexosamine pathway flux and high-fat feeding are not additive in inducing insulin resistance: evidence for a shared pathway. Amino Acids 40, 841–846.
CrossRef | CAS | PubMed |

Delbaere, I., Verstraelen, H., Goetgeluk, S., Martens, G., De Backer, G., and Temmerman, M. (2007). Pregnancy outcome in primiparae of advanced maternal age. Eur. J. Obstet. Gynecol. Reprod. Biol. 135, 41–46.
CrossRef | PubMed |

Diamond, M. P., Moley, K. H., Pellicer, A., Vaughn, W. K., and DeCherney, A. H. (1989). Effects of streptozotocin- and alloxan-induced diabetes mellitus on mouse follicular and early embryo development. J. Reprod. Fertil. 86, 1–10.
CrossRef | CAS | PubMed |

Dostrovsky, N. R., Towheed, T. E., Hudson, R. W., and Anastassiades, T. P. (2011). The effect of glucosamine on glucose metabolism in humans: a systematic review of the literature. Osteoarthritis Cartilage 19, 375–380.
CrossRef | CAS | PubMed |

Dunstan, D. W., Zimmet, P. Z., Welborn, T. A., De Courten, M. P., Cameron, A. J., Sicree, R. A., Dwyer, T., Colagiuri, S., Jolley, D., Knuiman, M., Atkins, R., and Shaw, J. E. (2002). The rising prevalence of diabetes and impaired glucose tolerance: the Australian Diabetes, Obesity and Lifestyle Study. Diabetes Care 25, 829–834.
CrossRef | PubMed |

Einstein, F. H., Fishman, S., Bauman, J., Thompson, R. F., Huffman, D. M., Atzmon, G., Barzilai, N., and Muzumdar, R. H. (2008). Enhanced activation of a nutrient-sensing pathway with age contributes to insulin resistance. FASEB J. 22, 3450–3457.
CrossRef | CAS | PubMed |

Ericsson, A., Säljö, K., Sjöstrand, E., Jansson, N., Prasad, P. D., Powell, T. L., and Jansson, T. (2007). Brief hyperglycaemia in the early pregnant rat increases fetal weight at term by stimulating placental growth and affecting placental nutrient transport. J. Physiol. 581, 1323–1332.
CrossRef | CAS | PubMed |

Fleming, T. P., Lucas, E. S., Watkins, A. J., and Eckert, J. J. (2012). Adaptive responses of the embryo to maternal diet and consequences for post-implantation development. Reprod. Fertil. Dev. 24, 35–44.
CrossRef |

Fowler, R. E. (1988). An autoradiographic study of gonadotrophin regulation of labelled glycoconjugates within preovulatory mouse follicles during the final stages of oocyte maturation, using [3H] glucosamine as the radioactive precursor. J. Reprod. Fertil. 83, 759–772.
CrossRef | CAS | PubMed |

Fowler, R. E., and Barratt, E. (1989). The uptake of [3H] glucosamine-labelled glycoconjugates into the perivitelline space of preimplantation mouse embryos. Hum. Reprod. 4, 821–825.
| CAS | PubMed |

Fowler, R. E., and Guttridge, K. (1987). An autoradiographic study using [3H] glucosamine of gonadotrophin regulation of proteoglycan and glycoprotein synthesis in developing mouse follicles. J. Reprod. Fertil. 81, 415–426.
CrossRef | CAS | PubMed |

Friede, A., Baldwin, W., Rhodes, P. H., Buehler, J. W., and Strauss, L. T. (1988). Older maternal age and infant mortality in the United States. Obstet. Gynecol. 72, 152–157.
| CAS | PubMed |

Fulop, N., Mason, M. M., Dutta, K., Wang, P., Davidoff, A. J., Marchase, R. B., and Chatham, J. C. (2007). Impact of Type 2 diabetes and aging on cardiomyocyte function and O-linked n-acetylglucosamine levels in the heart. Am. J. Physiol. Cell Physiol. 292, C1370–C1378.
CrossRef | CAS | PubMed |

Greene, M. F. (1999). Spontaneous abortions and major malformations in women with diabetes mellitus. Semin. Reprod. Endocrinol. 17, 127–136.
CrossRef | CAS | PubMed |

Hansen, J. P. (1986). Older maternal age and pregnancy outcome: a review of the literature. Obstet. Gynecol. Surv. 41, 726–742.
CrossRef | CAS | PubMed |

Heilig, C. W., Saunders, T., Brosius, F. C., Moley, K., Heilig, K., Baggs, R., Guo, L., and Conner, D. (2003). Glucose transporter-1-deficient mice exhibit impaired development and deformities similar to diabetic embryopathy. Proc. Natl. Acad. Sci. USA 100, 15 613–15 618.
CrossRef | CAS |

Horal, M., Zhang, Z., Stanton, R., Virkamaki, A., and Loeken, M. R. (2004). Activation of the hexosamine pathway causes oxidative stress and abnormal embryo gene expression: involvement in diabetic teratogenesis. Birth Defects Res. A Clin. Mol. Teratol. 70, 519–527.
CrossRef | CAS | PubMed |

Hsieh, T. T., Liou, J. D., Hsu, J. J., Lo, L. M., Chen, S. F., and Hung, T. T. (2010). Advanced maternal age and adverse perinatal outcomes in an Asian population. Eur. J. Obstet. Gynecol. Reprod. Biol. 148, 21–26.
CrossRef | PubMed |

Jacobsson, B., Ladfors, L., and Milsom, I. (2004). Advanced maternal age and adverse perinatal outcome. Obstet. Gynecol. 104, 727–733.
CrossRef | PubMed |

Jones, H. N., Woollett, L. A., Barbour, N., Prasad, P. D., Powell, T. L., and Jansson, T. (2009). High-fat diet before and during pregnancy causes marked up-regulation of placental nutrient transport and fetal overgrowth in C57/Bl6 mice. FASEB J. 23, 271–278.
CrossRef | CAS | PubMed |

Jungheim, E. S. (2010). Current knowledge of obesity’s effects in the pre- and peri-conceptional periods and avenues for future research. Am. J. Obstet. Gynecol. 203, 525–530.
CrossRef | PubMed |

Jungheim, E. S., and Moley, K. H. (2008). The impact of Type 1 and Type 2 diabetes mellitus on the oocyte and the preimplantation embryo. Semin. Reprod. Med. 26, 186–195.
CrossRef | CAS | PubMed |

Jungheim, E. S., Schoeller, E. L., Marquard, K. L., Louden, E. D., Schaffer, J. E., and Moley, K. H. (2010). Diet-induced obesity model: abnormal oocytes and persistent growth abnormalities in the offspring. Endocrinology 151, 4039–4046.
CrossRef | CAS | PubMed |

Kaneto, H., Xu, G., Song, K.-H., Suzuma, K., Bonner-Weir, S., Sharma, A., and Weir, G. C. (2001). Activation of the hexosamine pathway leads to deterioration of pancreatic β-cell function through the induction of oxidative stress. J. Biol. Chem. 276, 31 099–31 104.
CrossRef | CAS |

Kimura, K., Iwata, H., and Thompson, J. G. (2008). The effect of glucosamine concentration on the development and sex ratio of bovine embryos. Anim. Reprod. Sci. 103, 228–238.
CrossRef | CAS | PubMed |

Kitzmiller, J. L., Block, J. M., Brown, F. M., Catalano, P. M., Conway, D. L., Coustan, D. R., Gunderson, E. P., Herman, W. H., Hoffman, L. D., Inturrisi, M., Jovanovic, L. B., Kjos, S. I., Knopp, R. H., Montoro, M. N., Ogata, E. S., Paramsothy, P., Reader, D. M., Rosenn, B. M., Thomas, A. M., and Kirkman, M. S. (2008). Managing pre-existing diabetes for pregnancy: summary of evidence and consensus recommendation for care. Diabetes Care 31, 1060–1079.
CrossRef | CAS | PubMed |

Le Floch, J. P., Escuyer, P., Baudin, E., Baudin, D., and Perlemuter, L. (1990). Blood glucose area under the curve. Methodological aspects. Diabetes Care 13, 172–175.
CrossRef | CAS | PubMed |

Love, D. C., and Hanover, J. A. (2005). The hexosamine signalling pathway: deciphering the “O-GlcNAc code”. Sci. STKE 2005, re13.
CrossRef | PubMed |

Marshall, S., Bacote, V., and Traxinger, R. R. (1991). Discovery of a metabolic pathway mediating glucose-induced desensitisation of the glucose transport system. Role of hexosamine biosynthesis in the induction of insulin resistance. J. Biol. Chem. 266, 4706–4712.
| CAS | PubMed |

Martin, J. A., Hamilton, B. E., Sutton, P. D., Ventura, S. J., Menacker, F., and Munson, M. L. (2006). ‘Births: Final data for 2004. National Vital Statistics Reports, Vol. 55, No. 1’. (National Center for Health Statistics: Hyattsville, MD, USA.)

McCance, D. R. (2011). Pregnancy and diabetes. Best Pract. Res. Clin. Obstet. Gynaecol. 25, 945–958.
| CAS |

McClain, D. A. (2002). Hexosamines as mediators of nutrient sensing and regulation in diabetes. J. Diabetes Complications 16, 72–80.
CrossRef | PubMed |

McClain, D. A., and Crook, E. D. (1996). Hexosamines and insulin resistance. Diabetes 45, 1003–1009.
CrossRef | CAS | PubMed |

Metzger, B. E., Buchanan, T. A., Coustan, D. R., de Leiva, A., Dunger, D. B., Hadden, D. R., Hod, M., Kitzmiller, J. L., Kjos, S. L., Oats, J. N., Pettitt, D. J., Sacks, D. A., and Zoupas, C. (2007). Summary and recommendations of the Fifth International Workshop-Conference on Gestational Diabetes Mellitus. Diabetes Care 30, S251–S260.
CrossRef | CAS | PubMed |

Miletic, T., Aberle, N., Mikulandra, F., Karelovic, D., Zakani, Z., Banovic, I., Tadin, I., Perisa, M., Ognjenovic, M., and Tadic, C. (2002). Perinatal outcome of pregnancies in women aged 40 and over. Coll. Antropol. 26, 251–258.
| CAS | PubMed |

Miller, E., Hare, J. W., Cloherty, J. P., Dunn, P. J., Gleason, R. E., Soeldner, J. S., and Kitzmiller, J. L. (1981). Elevated maternal haemoglobin A1c in early pregnancy and major congenital anomalies in infants of diabetic mothers. N. Engl. J. Med. 304, 1331–1334.
CrossRef | CAS | PubMed |

Minge, C. E., Bennett, B. D., Norman, R. J., and Robker, R. L. (2008). Peroxisome proliferator-activated receptor-gamma agonist rosiglitazone reverses the adverse effects of diet-induced obesity on oocyte quality. Endocrinology 149, 2646–2656.
CrossRef | CAS | PubMed |

Moley, K. H., Vaughn, W. K., DeCherney, A. H., and Diamond, M. P. (1991). Effect of diabetes mellitus on mouse preimplantation embryo development. J. Reprod. Fertil. 93, 325–332.
CrossRef | CAS | PubMed |

Nybo Andersen, A. M., Wohlfahrt, J., Christens, P., Olsen, J., and Melbye, M. (2000). Maternal age and fetal loss: population-based register linkage study. BMJ 320, 1708–1712.
CrossRef | CAS | PubMed |

Pantaleon, M., Tan, H. Y., Kafer, G. R., and Kaye, P. L. (2010). Toxic effects of hyperglycaemia are mediated by the hexosamine signalling pathway and O-linked glycosylation in early mouse embryos. Biol. Reprod. 82, 751–758.
CrossRef | CAS | PubMed |

Parnell, S. E., Dehart, D. B., Wills, T. A., Chen, S., Hodge, C. W., Besheer, J., Waage-Baudet, H. G., Charness, M. E., and Sulik, K. K. (2006). Maternal oral intake mouse model for fetal alcohol spectrum disorders: ocular defects as a measure of effect. Alcohol. Clin. Exp. Res. 30, 1791–1798.
CrossRef | CAS | PubMed |

Patti, M. E., Virkamaki, A., Landaker, E. J., Kahn, C. R., and Yki-Jarvinen, H. (1999). Activation of the hexosamine pathway by glucosamine in vivo induces insulin resistance of early postreceptor insulin signalling events in skeletal muscle. Diabetes 48, 1562–1571.
CrossRef | CAS | PubMed |

Persiani, S., Roda, E., Rovati, L. C., Locatelli, M., Giacovelli, G., and Roda, A. (2005). Glucosamine oral bioavailability and plasma pharmacokinetics after increasing doses of crystalline glucosamine sulfate in man. Osteoarthritis Cartilage 13, 1041–1049.
CrossRef | CAS | PubMed |

Ramin, N., Thieme, R., Fischer, S., Schindler, M., Schmidt, T., Fischer, B., and Navarrete Santos, A. (2010). Maternal diabetes impairs gastrulation and insulin and IGF-I receptor expression in rabbit blastocysts. Endocrinology 151, 4158–4167.
CrossRef | CAS | PubMed |

Ray, J. G., O’Brien, T. E., and Chan, W. S. (2001). Preconception care and the risk of congenital anomalies in the offspring of women with diabetes mellitus: a meta-analysis. Q. J. Med. 94, 435–444.
CrossRef | CAS |

Robinson, K. A., Weinstein, M. L., Lindenmayer, G. E., and Buse, M. G. (1995). Effects of diabetes and hyperglycaemia on the hexosamine synthesis pathway in rat muscle and liver. Diabetes 44, 1438–1446.
CrossRef | CAS | PubMed |

Rossetti, L., Hawkins, M., Chen, W., Gindi, J., and Barzilai, N. (1995). In vivo glucosamine infusion induces insulin resistance in normoglycaemic but not hyperglycaemic conscious rats. J. Clin. Invest. 96, 132–140.
CrossRef | CAS | PubMed |

Salbaum, J. M., and Kappen, C. (2011). Diabetic embryopathy: a role for the epigenome? Birth Defects Res. A Clin. Mol. Teratol. 91, 770–780.
CrossRef | CAS | PubMed |

Schelbach, C. J., Kind, K. L., Lane, M., and Thompson, J. G. (2010). Mechanisms contributing to the reduced developmental competence of glucosamine-exposed mouse oocytes. Reprod. Fertil. Dev. 22, 771–779.
CrossRef | CAS | PubMed |

Setnikar, I., Palumbo, R., Canali, S., and Zanolo, G. (1993). Pharmacokinetics of glucosamine in man. Arzneimittelforschung 43, 1109–1113.
| CAS | PubMed |

Shand, A. W., Bell, J. C., McElduff, A., Morris, J., and Roberts, C. L. (2008). Outcomes of pregnancies in women with pre-gestational diabetes mellitus and gestational diabetes mellitus; a population-based study in New South Wales, Australia, 1998–2002. Diabet. Med. 25, 708–715.
CrossRef | CAS | PubMed |

Simmons, D. (2011). Diabetes and obesity in pregnancy. Best Pract. Res. Clin. Obstet. Gynaecol. 25, 25–36.
CrossRef | PubMed |

Simon, R. R., Marks, V., Leeds, A. R., and Anderson, J. W. (2011). A comprehensive review of oral glucosamine use and effects on glucose metabolism in normal and diabetic individuals. Diabetes Metab. Res. Rev. 27, 14–27.
CrossRef | CAS | PubMed |

Sivojelezova, A., Koren, G., and Einarson, A. (2007). Glucosamine use in pregnancy: an evaluation of pregnancy outcome. J. Womens Health Larchmt 16, 345–348.
CrossRef | PubMed |

Spampinato, D., Giaccari, A., Trischitta, V., Costanzo, B. V., Morviducci, L., Buongiorno, A., Di Mario, U., Vigneri, R., and Frittitta, L. (2003). Rats that are made insulin resistant by glucosamine treatment have impaired skeletal muscle insulin receptor phosphorylation. Metabolism 52, 1092–1095.
CrossRef | CAS | PubMed |

Stothard, K. J., Tennant, P. W., Bell, R., and Rankin, J. (2009). Maternal overweight and obesity and the risk of congenital anomalies: a systematic review and meta-analysis. JAMA 301, 636–650.
CrossRef | CAS | PubMed |

Sulik, K. K., Johnston, M. C., and Webb, M. A. (1981). Fetal alcohol syndrome: embryogenesis in a mouse model. Science 214, 936–938.
CrossRef | CAS | PubMed |

Sutton-McDowall, M. L., Gilchrist, R. B., and Thompson, J. G. (2004). Cumulus expansion and glucose utilisation by bovine cumulus–oocyte complexes during in vitro maturation: the influence of glucosamine and follicle-stimulating hormone. Reproduction 128, 313–319.
CrossRef | CAS | PubMed |

Sutton-McDowall, M. L., Mitchell, M., Cetica, P., Dalvit, G., Pantaleon, M., Lane, M., Gilchrist, R. B., and Thompson, J. G. (2006). Glucosamine supplementation during in vitro maturation inhibits subsequent embryo development: possible role of the hexosamine pathway as a regulator of developmental competence. Biol. Reprod. 74, 881–888.
CrossRef | CAS | PubMed |

Temple, R. C., Aldridge, V. J., and Murphy, H. R. (2006). Prepregnancy care and pregnancy outcomes in women with Type 1 diabetes. Diabetes Care 29, 1744–1749.
CrossRef | PubMed |

Teo, C. F., Wollaston-Hayden, E. E., and Wells, L. (2010). Hexosamine flux, the O-GlcNAc modification and the development of insulin resistance in adipocytes. Mol. Cell. Endocrinol. 318, 44–53.
CrossRef | CAS | PubMed |

Torres, C. R., and Hart, G. W. (1984). Topography and polypeptide distribution of terminal n-acetylglucosamine residues on the surfaces of intact lymphocytes. Evidence for O-linked GlcNAc. J. Biol. Chem. 259, 3308–3317.
| CAS | PubMed |

Vaughan, O. R., Sferruzzi-Perri, A. N., Coan, P. M., and Fowden, A. L. (2012). Environmental regulation of placental phenotype. Reprod. Fertil. Dev. 24, 80–96.
CrossRef |

Veerababu, G., Tang, J., Hoffman, R. T., Daniels, M. C., Hebert, L. F., Crook, E. D., Cooksey, R. C., and McClain, D. A. (2000). Overexpression of glutamine: fructose-6-phosphate amidotransferase in the liver of transgenic mice results in enhanced glycogen storage, hyperlipidemia, obesity and impaired glucose tolerance. Diabetes 49, 2070–2078.
CrossRef | CAS | PubMed |

Virkamaki, A., Daniels, M. C., Hamalainen, S., Utriainen, T., McClain, D., and Yki-Jarvinen, H. (1997). Activation of the hexosamine pathway by glucosamine in vivo induces insulin resistance in multiple insulin-sensitive tissues. Endocrinology 138, 2501–2507.
CrossRef | CAS | PubMed |

Vosseller, K., Wells, L., Lane, M. D., and Hart, G. W. (2002). Elevated nucleocytoplasmic glycosylation by O-GlcNAc results in insulin resistance associated with defects in Akt activation in 3T3–L1 adipocytes. Proc. Natl. Acad. Sci. USA 99, 5313–5318.
CrossRef | CAS | PubMed |

Waller, D. K., Shaw, G. M., Rasmussen, S. A., Hobbs, C. A., Canfield, M. A., Siega-Riz, A. M., Gallaway, M. S., and Correa, A. (2007). Prepregnancy obesity as a risk factor for structural birth defects. Arch. Pediatr. Adolesc. Med. 161, 745–750.
CrossRef | PubMed |

Wang, Q., and Moley, K. H. (2010). Maternal diabetes and oocyte quality. Mitochondrion 10, 403–410.
CrossRef | PubMed |

Wang, Q., Ratchford, A. M., Chi, M. M.-Y., Schoeller, E., Frolova, A., Schedl, T., and Moley, K. H. (2009). Maternal diabetes causes mitochondrial dysfunction and meiotic defects in murine oocytes. Mol. Endocrinol. 23, 1603–1612.
CrossRef | CAS | PubMed |

Wang, Y. C., McPherson, K., Marsh, T., Gortmaker, S. L., and Brown, M. (2011). Health and economic burden of the projected obesity trends in the USA and the UK. Lancet 378, 815–825.
CrossRef | PubMed |

Wyman, A., Pinto, A. B., Sheridan, R., and Moley, K. H. (2008). One-cell zygote transfer from diabetic to non-diabetic mouse results in congenital malformations and growth retardation in offspring. Endocrinology 149, 466–469.
CrossRef | CAS | PubMed |


   
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