The field of molluscan research has flourished since the times of Linnaeus, and more recently great advances have been made in multiple areas from deep phylogenies to species delimitation analyses using molecular and morphological data. In this virtual issue, we have compiled a collection of articles covering a diversity of taxa (Bivalvia, Cephalopoda, Gastropoda, Polyplacophora) and approaches (molecular, morphological – including morphometrics – and total evidence) to better understand molluscan diversification at different time-scales. These articles encompass work conducted in Australia, New Zealand, Asia, the Americas and Europe and include work and species found globally, highlighting both the interdisciplinary and collaborative nature of the science published in Invertebrate Systematics.