Myriapoda and Onychophora constitute two clades of mostly soil-dwelling multi-legged panarthropods, once thought to form the clade Uniramia, but now genomic evidence strongly suggest that Onychophora is the sister group of Arthropoda, where myriapods are nested. Their ecological roles as predators (onychophorans and centipedes) or as major groups digesting vegetal matter in the soil (millepedes) make them some of the most important and oldest inhabitants of forests around the world. In addition, several lineages have also adapted to dry environments. Invertebrate Systematics has traditionally published major studies on the systematics, biogeography and species delimitation of myriapods and onychophorans, and continues to seek high-quality integrative papers using these two groups as models. We also hope to incorporate studies on the two other groups of myriapods, symphylans and pauropods, to make our journal a major venue to cover evolutionary biology research in myriapods and onychophorans. The articles compiled in this virtual issue include several examples of the integrative work we expect to publish in our journal, and welcome submissions of your best work on myriapods and onychophorans.