Marine and Freshwater Research Marine and Freshwater Research Society
Advances in the aquatic sciences

Paralytic shellfish poisons from Australian cyanobacterial blooms

AR Humpage, J Rositano, AH Bretag, R Brown, PD Baker, BC Nicholson and DA Steffensen

Australian Journal of Marine and Freshwater Research 45(5) 761 - 771
Published: 1994


Saxitoxin-group neurotoxins (paralytic shellfish poisons) have been identified in a cultured strain of Anabaena circinalis and in natural bloom samples in which this species was the dominant organism collected from widely distributed sites in the Murray-Darling Basin of Australia. These toxins have hitherto been isolated almost exclusively from 'red tide' dinoflagellates and contaminated shellfish. Two 'aphantoxins', which appear to be identical to two of the paralytic shellfish poisons, have been identified in a cyanobacterium from a small number of sites in New Hampshire, USA. The conclusions are supported by electrophysiological studies and by high-performance liquid chromatographic (HPLC) and fast atom bombardment-mass spectrometric (FAB-MS) analyses.

Keywords: gonyautoxin. C-toxin, sodium-channel blockers, Aphanizomenon flos-aquae, PSP

© CSIRO 1994

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