The amount of information currently available about the genomes of many livestock species, especially cattle and pigs, has increased dramatically in the past few years and the rate of its accumulation will continue to increase. A large number of scientific ‘tools’ is currently available for research aimed at understanding biological processes important to livestock production. These resources are being used to understand biological processes regulating reproduction, body composition and immune function in all livestock species. This research will create many opportunities to develop new tools for the improvement of livestock production. The best commercial application of genomics is in conjunction with reproductive enhancing technologies, such as artificial insemination, embryo transfer and cloning.