Register      Login
Reproduction, Fertility and Development Reproduction, Fertility and Development Society
Vertebrate reproductive science and technology
RESEARCH ARTICLE

Insights and applications from sequencing the bovine genome

David L. Adelson
+ Author Affiliations
- Author Affiliations

A Centre for Bioinformatics and Computational Genetics, School of Molecular and Biomedical Science, School of Agriculture, Food and Wine, The University of Adelaide, Adelaide, SA 5005, Australia.

B Email: david.adelson@adelaide.edu.au

Reproduction, Fertility and Development 20(1) 54-60 https://doi.org/10.1071/RD07157
Published: 12 December 2007

Abstract

Humans have sought to improve/tailor cattle since their domestication a few thousand years ago. Up until the last 40–50 years, consistent genetic improvement of cattle was a hit or miss proposition. Recent progress has been more rapid, thanks to applications of quantitative genetics to breeding schemes. With the availability of the bovine genome sequence, genetic selection and on-farm management are likely to be revolutionised yet again. Genetic association studies that were previously impossible to carry out due to a lack of markers are now possible. In addition to improved genetic mapping of economic traits, the bovine genome sequence allows us to create a common context for genetic and physiological data, which will provide novel insights into gene regulation and function.


References

Beja-Pereira, A. , Caramelli, D. , Lalueza-Fox, C. , Vernesi, C. , and Ferrand, N. , et al. (2006). The origin of European cattle: Evidence from modern and ancient DNA. Proc. Natl Acad. Sci. USA 103, 8113–8118.
Crossref | GoogleScholarGoogle Scholar | PubMed | BGS Consortium (2007). ‘Bovine Genome Project.’ Available at http://www.hgsc.bcm.tmc.edu [Verified 1 August 2007].

Billars, L. , Hicks, A. , Bliwise, D. , Sigmundsson, T. , Sigurdsson, A. , Kristjansson, K. , Gulcher, J. , Stefansson, K. , and Rye, D. (2007). Hypertension risk and PLMS in restless legs syndrome. Sleep 30((Suppl.)), A297–A298.[Abstract]
Dalrymple B. (2006). ‘Virtual Sheep Genome.’ Available at http://www.livestockgenomics.csiro.au/vsheep/ [Verified 1 August 2007].

Edwards, C. J. , Bollongino, R. , Scheu, A. , Chamberlain, A. , and Tresset, A. , et al. (2007). Mitochondrial DNA analysis shows a Near Eastern Neolithic origin for domestic cattle and no indication of domestication of European aurochs. Proc. Biol. Sci. 274, 1377–1385.
Crossref | GoogleScholarGoogle Scholar | Elsik C. G., Antoniou E., Fahrenkrug S. C., Reecy J. M., Wolfinger R. D., and Taylor J. F. (2006). A bovine whole genome long oligonucleotide expression array. In ‘Proceedings of the 30th International Conference on Animal Genetics’. p. 68. (International Society for Animal Genetics: Brazil.)

Garcia-Closas, M. , Malats, N. , Real, F. X. , Yeager, M. , and Welch, R. , et al. (2007). Large-scale evaluation of candidate genes identifies associations between VEGF polymorphisms and bladder cancer risk. PLoS Genet. 3, 287–293.
Crossref | GoogleScholarGoogle Scholar | Gibbs R., Weinstock G., Kappes S., Schook L., Skow L., and Womack J. E. (2002). ‘Bovine genomic sequencing initiative: cattleizing the human genome.’ Available at http://www.genome.gov/Pages/Research/Sequencing/SeqProposals/BovineSEQ.pdf [Verified 1 August 2007].

Gotherstrom, A. , Anderung, C. , Hellborg, L. , Galil, R. , Smith, E. C. , Bradley, D. G. , and Ellegren, H. (2005). Cattle domestication in the Near East was followed by hybridization with aurochs bulls in Europe. Proc. Biol. Sci. 272, 2345–2350.
Crossref | GoogleScholarGoogle Scholar | Kappes S. M., Green R. D., and Van Tassell C. P. (2006). ‘Sequencing the bovine genome and developing a haplotype map: approaches and opportunities.’ Available at http://www.wcgalp8.org.br/wcgalp8/articles/paper/22_937-1395.pdf [Verified 1 August 2007].

Kulikova, T. , Akhtar, R. , Aldebert, P. , Althorpe, N. , and Andersson, M. , et al. (2007). EMBL Nucleotide Sequence Database in 2006. Nucleic Acids Res. 35, D16–D20.
Crossref | GoogleScholarGoogle Scholar | PubMed | Oklahoma S. (1994). Breeds of livestock. Available at http://www.ansi.okstate.edu/breeds/cattle/ [Verified 1 August 2007].

Polineni, P. , Aragonda, P. , Xavier, S. R. , Furuta, R. , and Adelson, D. L. (2006). The bovine QTL viewer: a web accessible database of bovine quantitative trait loci. BMC Bioinformatics 7, 283.
Crossref | GoogleScholarGoogle Scholar | PubMed | Russo T. P., and Klein M. (2007). ‘Cargill and MMI Genomics launch Tru-Marbling™ and Tru-Tenderness™ DNA based selection products.’ Available at http://www.metamorphixinc.com/013107%20MMICargill.pdf [Verified 12 August 2007].

Schymick, J. C. , Scholz, S. W. , Fung, H. , Britton, A. , Arepalli, S. , Gibbs, J. , Lombardo, F. , Matarin, M. , Kasperaviciute, D. , and Hernandez, D. (2007). Genome-wide genotyping in amyotrophic lateral sclerosis and neurologically normal controls: first stage analysis and public release of data. Lancet Neurol. 6, 322–328.
Crossref | GoogleScholarGoogle Scholar | PubMed | Weiss B., Piry S., Steinbach D., Samson F., and Eggen A. (1995). ‘Bovmap database.’ Available at http://locus.jouy.inra.fr/cgi-bin/bovmap/intro2.pl [Verified 1 August 2007].

Wheeler, D. L. , Barrett, T. , Benson, D. A. , Bryant, S. H. , and Canese, K. , et al. (2007). Database resources of the National Center for Biotechnology Information. Nucleic Acids Res. 35, D5–D12.
Crossref | GoogleScholarGoogle Scholar | PubMed |