Altered gene expression in cloned piglets

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Contents Vol 21(1)

doi:10.1071/RD08214

Altered gene expression in cloned piglets

X. Cindy Tian ^A ^F, Joonghoon Park ^A, Richard Bruno ^B, Richard French ^C, Le Jiang ^A ^E, Randall S. Prather ^D

^A Department of Animal Science and Center for Regenerative Biology, University of Connecticut, Storrs, CT 06269, USA.
^B Department of Nutritional Science, University of Connecticut, Storrs, CT 06269, USA.
^C Department of Molecular, Cellular and Biomedical Sciences, University of New Hampshire, Durham, NH 03824, USA.
^D Department of Animal Science, University of Missouri-Columbia, Columbia, MO 65211, USA.
^E Present address: Institute for Cancer Genetics, Irving Comprehensive Research Center, Columbia University, New York, NY 10032, USA.
^F Corresponding author. Email: xiuchun.tian@uconn.edu





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Reproduction, Fertility and Development 21(1) 60–66 http://dx.doi.org/10.1071/RD08214
Published online: 9 December 2008

Abstract

Studies on cloned pigs are scant compared with those in mice and cattle. Expression profiles of cloned pig embryos on full-term cloned pigs are even more limited owing to the limited availability of DNA microarray technology in the pig. We have conducted expression profile comparisons between pigs from somatic cell nuclear transfer and pigs from conventional breeding at birth and 1 month of age. Differentially expressed genes that are subjected to DNA methylation were also examined for their DNA methylation status. These data will be presented in the 2009 Annual Meeting of the International Embryo Transfer Society in San Diego. In the present review, we focus on summarising existing findings on epigenetic and other changes in cloned embryo, cloned pigs and their offspring by conventional breeding.