CSIRO Publishing Books Journals About Us Shopping Cart You are here: Journals > Reproduction, Fertility and Development   
Reproduction, Fertility and Development
  Vertebrate Reproductive Science & Technology
 
Search
 
 
  Advanced Search
   

Journal Home
About the Journal
Editorial Board
Contacts
Content
Online Early
Current Issue
Just Accepted
All Issues
Special Issues
Research Fronts
Sample Issue
For Authors
General Information
Instructions to Authors
Submit Article
Open Access
For Referees
General Information
Review Article
For Subscribers
Subscription Prices
Customer Service
Print Publication Dates

 Early Alert
Subscribe to our email Early Alert or RSS feeds for the latest journal papers.

 Connect with us
facebook   youtube

Training

Publication Workshops


 

Article << Previous     |     Next >>   Contents Vol 22(1)

Brief introduction to whole-genome selection in cattle using single nucleotide polymorphisms

G. E. Seidel

Animal Reproduction and Biotechnology Laboratory, Colorado State University, Fort Collins, CO 80523-1683, USA. Email: gseidel@colostate.edu
 
PDF (167 KB) $25
 Export Citation
 Print
  


Abstract

Genomic selection using single nucleotide polymorphisms (SNPs) is a powerful new tool for genetic selection. In cattle, SNP profiles for individual animals are generated using a small plastic chip that is diagnostic for up to 50 000 SNPs spaced throughout the genome. Phenotypes, usually averaged over offspring of bulls, are matched with SNP profiles of bulls mathematically so that animals can be ranked for siring desirable phenotypes via their SNP profiles. For many traits in dairy cattle, the rate of genetic improvement can be nearly doubled when SNP information is used in addition to current methods of genetic evaluation. Separate SNP analyses need to be developed for different populations (e.g. the system for Holsteins is not useful for Jerseys). In addition, the value of these systems is very dependent on the number of accurate phenotypes matched with SNP profiles; for example, increasing the number of North American Holstein bulls evaluated from 1151 to 3576 quadrupled the additional genetic gain in net merit from this approach. Thus, the available information will be insufficient to exploit this technology fully for most populations. However, once a valid SNP evaluation system is developed, any animal in that population, including embryos, can be evaluated with similar accuracy. Biopsying embryos and screening them via SNP analysis will greatly enhance the value of this technology by minimising generation intervals.

Keywords: breeding, embryo, genetics, genomics, SNP.


   
Subscriber Login
Username:
Password:  

    


 
Top  Email this page
 
Legal & Privacy | Contact Us | Help

CSIRO

© CSIRO 1996-2012