Selected a,a'-Dimethyl Disulfides: Submicrogram Fungitoxins

Felix Jakob Baerlocher, Mark Otto Baerlocher, Kristal Dawn Guckert, Richard Francis Langler, Stephanie Lee MacQuarrie, Paul Eric O'Connor and Gabriel Carl Yan Sung

Abstract

Recently developed synthetic methodology has been exploited for the preparation of an assortment of α,α´-disubstituted disulfides including all three linkage isomeric types of α,α´-diester dimethyl disulfides. Two of the diesters are very powerful antifungal agents against Aspergillus niger and Aspergillus flavus. An α-ester α´-sulfone disulfide is the most powerful fungitoxin developed by this ongoing research effort.

Australian Journal of Chemistry 54(6) 397 - 400 (2001) doi:10.1071/CH01046