Abstract

Recently developed synthetic methodology has been exploited for the preparation of an assortment of α,α´-disubstituted disulfides including all three linkage isomeric types of α,α´-diester dimethyl disulfides. Two of the diesters are very powerful antifungal agents against Aspergillus niger and Aspergillus flavus. An α-ester α´-sulfone disulfide is the most powerful fungitoxin developed by this ongoing research effort.