Ether Aryl Sulfonic Acid Esters with Improved Antimalarial/Anticancer Activities

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Contents Vol 59(4)

doi:10.1071/CH04299

Ether Aryl Sulfonic Acid Esters with Improved Antimalarial/Anticancer Activities

Lynn M. Betts ^A, Nga Chiu Tam ^A, S. M. Humayun Kabir ^A, Richard F. Langler ^A ^C, Ian Crandall ^B ^D

^A Department of Chemistry, Mount Allison University, Sackville, New Brunswick E4L 1G8, Canada.
^B Tropical Disease Unit, Department of Medicine, Toronto General Hospital and the University of Toronto, Toronto, Ontario M5S 1A8, Canada.
^C Corresponding author (organic chemistry). Email: rlangler@mta.ca
^D Corresponding author (biological testing). Email: ian.crandall@utoronto.ca





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Australian Journal of Chemistry 59(4) 277–282 http://dx.doi.org/10.1071/CH04299
Submitted: 20 December 2004 Accepted: 10 March 2006 Published online: 1 May 2006

Abstract

Our previous report showed that our current benchmark agent, 4-methoxyphenyl p-toluenesulfonate, is a selective antimalarial/anticancer agent. A series of related sulfones and sulfonic acid esters is now examined. 4-Allyloxyphenyl p-toluenesulfonate is a superior antimalarial/anticancer agent. 4-Methoxyphenyl 4-nitrobenzenesulfonate is a superior antimalarial agent, but shows poorer inhibition of human skin cancer cells.