Cell Scaffolds with Three-Dimensional Order: The Role of Modelling in Establishing Design Guidelines

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Contents Vol 58(10)

doi:10.1071/CH05150

Cell Scaffolds with Three-Dimensional Order: The Role of Modelling in Establishing Design Guidelines

Sachin Shanbhag ^A, Jungwoo Lee ^B, Nicholas A. Kotov ^A ^D

^A Department of Chemical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.
^B Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.
^C Department of Materials Science and Engineering, University of Michigan, Ann Arbor, MI 48109, USA.
^D Corresponding author. Email: kotov@umich.edu





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Australian Journal of Chemistry 58(10) 713–715 http://dx.doi.org/10.1071/CH05150
Submitted: 19 June 2005 Accepted: 25 August 2005 Published online: 8 November 2005

Abstract

The architectural uniformity of highly ordered cell scaffolds with inverted colloidal crystal geometry is exploited by modelling the movement of cells and nutrients in the scaffold using Brownian dynamics simulations. The extent of cell–scaffold interaction and the diffusion of the cells in the scaffold are explicitly examined. A procedure to identify a suitable region in the available design space is suggested and evaluated against earlier experimental observations.