α-Phenylethyl Substituted Bis(pivaloyloxymethyl) Ester Analogues of Fosmidomycin and FR900098

Article

<< Previous

Next >>

Contents Vol 60(3)

doi:10.1071/CH07018

α-Phenylethyl Substituted Bis(pivaloyloxymethyl) Ester Analogues of Fosmidomycin and FR900098

Thomas Kurz ^A, Christoph Behrendt ^A, Uwe Kaula ^A, Bärbel Bergmann ^B, Rolf D. Walter ^B

^A Institute of Pharmacy, University of Hamburg, Bundesstraße 45, 20146 Hamburg, Germany.
^B Bernhard Nocht Institute for Tropical Medicine, Bernhard-Nocht-Straße 74, D-20359 Hamburg, Germany.
^C Corresponding author. Email: kurz@chemie.uni-hamburg.de





	PDF (261 KB) $25



	Export Citation

Print

Australian Journal of Chemistry 60(3) 154–158 http://dx.doi.org/10.1071/CH07018
Submitted: 22 January 2007 Accepted: 23 February 2007 Published online: 2 April 2007

Abstract

α-Phenylethyl substituted bis(pivaloyloxymethyl) ester analogues of the natural products Fosmidomycin and FR900098 have been synthesized, and their in vitro antimalarial activity determined. The α-phenylethyl substituted Fosmidomycin analogue displays moderate in vitro antimalarial activity against the chloroquine-sensitive strain 3D7 of Plasmodium falciparum.