Copper(II) Complexes with Reduced Schiff Base: Synthesis, Spectroscopic, Thermal, X-Ray, and Cytotoxic Studies of Novel Copper(II) Complexes with an Arylpyrazole Ligand

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Contents Vol 60(8)

doi:10.1071/CH07183

Copper(ii) Complexes with Reduced Schiff Base: Synthesis, Spectroscopic, Thermal, X-Ray, and Cytotoxic Studies of Novel Copper(ii) Complexes with an Arylpyrazole Ligand

Vukadin M. Leovac ^A, Petra Bombicz ^B, Katalin Mészáros Szécsényi ^A, Milan D. Joksović ^D ^D

^A Faculty of Sciences, University of Novi Sad, Trg D. Obradovića 3, 21000 Novi Sad, Serbia.
^B Institute of Structural Chemistry, Chemical Research Center, Hungarian Academy of Sciences, PO Box 17, H-1525 Budapest, Hungary.
^C Faculty of Sciences, University of Kragujevac, R. Domanovica 12, 34000 Kragujevac, Serbia.
^D Corresponding author. Email: mjoksovic@kg.ac.yu





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Australian Journal of Chemistry 60(8) 615–620 http://dx.doi.org/10.1071/CH07183
Submitted: 30 May 2007 Accepted: 6 July 2007 Published online: 9 August 2007

Abstract

The synthesis of a novel arylpyrazole-derived ligand, 1,2-bis[(1,3-diphenylpyrazol-4-yl)methyl]diaminoethane (Ph₄Pz₂mde), and its complexes prepared with CuCl₂ [Cu(Ph₄Pz₂mde)Cl₂(MeOH)] 1, CuBr₂ [Cu(Ph₄Pz₂mde)Br₂(MeOH)] 2, from MeOH, and [Cu(Ph₄Pz₂mde)Cl₂(DMF)] 3, from a mixture of MeOH and DMF, are described. The complexes are characterized by elemental and thermal analysis and FT-IR spectroscopy, while the ¹H and ¹³C NMR assignments are given for the ligand. The crystal and molecular structure of [Cu(Ph₄Pz₂mde)Cl₂(DMF)] was determined by single-crystal X-ray diffraction. In-vitro cytotoxicity of the Ph₄Pz₂mde ligand and two copper(ii) complexes was obtained using sulforhodamine B (SRB) treatment against three human tumour cell lines: HeLa (epitheloid carcinoma of cervix), MCF-7 (breast adenocarcinoma), and MRC-5 (lung fetal fibroblasts).