Synthesis, Characterization, and Properties of Copolyanhydrides Based on 2-Octylsuccinic Acid and Sebacic Acid

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Contents Vol 61(10)

doi:10.1071/CH07315

Synthesis, Characterization, and Properties of Copolyanhydrides Based on 2-Octylsuccinic Acid and Sebacic Acid

Yousef M. Hamdan ^A ^B, Shitao Fu ^A ^B, Xiangmei Jiang ^A, Yinhua Cheng ^A, Kaixun Huang ^A, Kaichao Yu ^A ^C

^A Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medica, Department of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074, China.
^B These authors contributed equally to this work.
^C Corresponding author. Email: yukc@163.com





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Australian Journal of Chemistry 61(10) 762–767 http://dx.doi.org/10.1071/CH07315
Submitted: 6 September 2007 Accepted: 7 August 2008 Published online: 6 October 2008

Abstract

2-Octylsuccinic acid and its copolyanhydrides with sebacic acid have been synthesized by melt polycondensation, and were characterized by Fourier transform infrared spectroscopy, ¹H NMR, gel permeation chromatography, differential scanning calorimetry, and thermal gravimetric analysis. In vitro studies showed that all copolymers are degradable in phosphate buffer at 37°C. The release profiles of the hydrophilic model drug ciprofloxacin hydrochloride follow first-order release kinetics.