Synthesis, Characterization, and DNA Binding Studies of Ruthenium(II) Complexes with 2-Pyridyl-1H-anthra[1,2-d]imidazole-6,11-dione

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doi:10.1071/CH08127

Synthesis, Characterization, and DNA Binding Studies of Ruthenium(ii) Complexes with 2-Pyridyl-1H-anthra[1,2-d]imidazole-6,11-dione

Yi-Xian Yuan ^A, Yi-Can Wang ^A, Long Jiang ^A, Feng Gao ^A, Si-Min Liang ^A, Cheng-Yong Su ^A, Hui Chao ^A ^B, Liang-Nian Ji ^A ^B

^A MOE Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, China.
^B Corresponding authors. Email: ceschh@mail.sysu.edu.cn, cesjln@mail.sysu.edu.cn





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Australian Journal of Chemistry 61(9) 732–739 http://dx.doi.org/10.1071/CH08127
Submitted: 29 March 2008 Accepted: 23 July 2008 Published online: 5 September 2008

Abstract

Three novel asymmetric ruthenium(ii) complexes, [Ru(bpy)₂(PAIDH)]²⁺ 1, [Ru(phen)₂(PAIDH)]²⁺ 2, and [Ru(dmp)₂(PAIDH)]²⁺ 3 (bpy = 2,2′-bipyridine, phen = 1,10-phenanthroline, dmp = 2,9-dimethyl-1,10-phenanthroline, PAIDH = 2-pyridyl-1H-anthra[1,2-d]imidazole-6,11-dione), have been synthesized and characterized. The structure of the deprotonated complex [Ru(dmp)₂(PAID)]⁺ 4 has been determined by single-crystal X-ray diffraction techniques, and the anthraquinone moiety is approximately coplanar with the imidazole ring. The DNA binding properities of complexes 1, 2, and 3 to calf-thymus DNA (CT-DNA) were investigated. Spectroscopic studies and viscosity experiments suggest that the Ru^II complexes intercalate into DNA base pairs by the extended anthraquinone unit, and the ancillary ligands have significant effects on the spectroscopic properties and DNA binding behaviour of the Ru^II complexes.