Identification of Chaetoviridin E from a Cultured Microfungus, Chaetomium sp. and Structural Reassignment of Chaetoviridins B and D

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Contents Vol 62(3)

doi:10.1071/CH08259

Identification of Chaetoviridin E from a Cultured Microfungus, Chaetomium sp. and Structural Reassignment of Chaetoviridins B and D

Sally R. Kingsland ^A, Russell A. Barrow ^A ^B

^A Department of Chemistry, College of Science, Australian National University, Canberra, ACT 0200, Australia.
^B Corresponding author. Email: rab@anu.edu.au





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Australian Journal of Chemistry 62(3) 269–274 http://dx.doi.org/10.1071/CH08259
Submitted: 18 June 2008 Accepted: 29 January 2009 Published online: 20 March 2009

Abstract

Chaetoviridins E (1) and B (2) are antibiotic active components isolated from the mycelial extract of an elicited laboratory-cultured coprophilous fungus, Chaetomium sp. obtained from the scat of an emu. The structure of chaetoviridin E was determined to be diastereomeric with the known compound chaetoviridin A, whereas a structure revision of chaetoviridins B and D (10) is proposed, reassigning them to be bicyclic lactol-lactones. The structures of chaetoviridins B and E were determined by detailed spectroscopic analysis, while the revision of chaetoviridin D is through analogy.