Controllable Synthesis of Pyrazolo[3,4-b]pyridines or Substituted Malononitrile Derivatives through Multi-Component Reactions in Ionic Liquid

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doi:10.1071/CH08290

Controllable Synthesis of Pyrazolo[3,4-b]pyridines or Substituted Malononitrile Derivatives through Multi-Component Reactions in Ionic Liquid

Xinying Zhang ^A ^B, Xiaoyan Li ^A, Xuesen Fan ^A ^B, Xia Wang ^A, Jianji Wang ^A, Guirong Qu ^A

^A School of Chemistry and Environmental Sciences, Henan Key Laboratory for Environmental Pollution Control, Henan Normal University, Xinxiang, Henan 453007, China.
^B Corresponding authors. Email: xyzh518@sohu.com; xuesen.fan@yahoo.com





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Australian Journal of Chemistry 62(4) 382–388 http://dx.doi.org/10.1071/CH08290
Submitted: 9 July 2008 Accepted: 31 December 2008 Published online: 24 April 2009

Abstract

A multi-component reaction of aldehyde, malononitrile, and 5-amino-3-methyl-1-phenylpyrazole was carried out smoothly in [bmim][BF₄] without any added catalyst. Through this reaction, pyrazolo[3,4-b]pyridines or substituted malononitrile derivatives were obtained conveniently and controllably at different temperatures. The ionic liquid used can be easily recovered and efficiently reused for at least five runs.