Graphisins A and B from the Lichen Graphis tetralocularis

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Contents Vol 62(4)

doi:10.1071/CH08313

Graphisins A and B from the Lichen Graphis tetralocularis

Pattama Pittayakhajonwut ^A ^B, Veera Sri-indrasutdhi ^A, Aibrohim Dramae ^A, Sanisa Lapanun ^A, Rapheephat Suvannakad ^A, Morakot Tantichareon ^A

^A National Center for Genetic Engineering and Biotechnology (BIOTEC), Thailand Science Park, Paholyothin Rd., Klong Luang, Pathumthani, 12120, Thailand.
^B Corresponding author. Email: pattamap@biotec.or.th





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Australian Journal of Chemistry 62(4) 389–391 http://dx.doi.org/10.1071/CH08313
Submitted: 22 July 2008 Accepted: 18 February 2009 Published online: 24 April 2009

Abstract

Crude extracts of the lichen Graphis tetralocularis exhibited antimycobacterial activity, with minimum inhibitory concentration (MIC) values in a range of 100–200 μg mL^–1. Chemical investigation of the broth led to the isolation of acremonidin E (1) and graphisins A (2) and B (3). Acremonidin E (1) displayed antitubercular activity with MIC values of 50 μg mL^–1 and showed cytotoxicity against BC, KB, and NCI-H187 cell lines with IC₅₀ values of 12.79–27.12 μg mL^–1, whereas graphisins A (2) and B (3) were inactive to these tests.