An Efficient and Simple One-Pot Synthesis of ?-Acetamido Ketones Catalyzed by Ytterbium Triflate in Ionic Liquid

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Contents Vol 62(4)

doi:10.1071/CH08557

An Efficient and Simple One-Pot Synthesis of β-Acetamido Ketones Catalyzed by Ytterbium Triflate in Ionic Liquid

Anil Kumar ^A ^B, M. Sudershan Rao ^A, Israr Ahmad ^A, Bharti Khungar ^A

^A Chemistry Group, Birla Institute of Technology and Science, Pilani 333 031, India.
^B Corresponding author. Email: anilkumar@bits-pilani.ac.in





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Australian Journal of Chemistry 62(4) 322–327 http://dx.doi.org/10.1071/CH08557
Submitted: 18 December 2008 Accepted: 4 March 2009 Published online: 24 April 2009

Abstract

Ytterbium triflate immobilized in the ionic liquid [bmim][BF₄] catalyzes the three-component coupling of aromatic aldehydes, enolizable ketones, and acetonitrile in the presence of acetyl chloride at room temperature to afford β-acetamido ketones in good yields. The catalyst can be recovered and recycled for subsequent reactions without any appreciable loss of efficiency.