Chiral Amine-Mediated Asymmetric Conjugate Additions to Vinyl Sulfones

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Contents Vol 62(9)

doi:10.1071/CH09137

Chiral Amine-Mediated Asymmetric Conjugate Additions to Vinyl Sulfones

Qiang Zhu ^A ^B, Yixin Lu ^A ^B ^C

^A Department of Chemistry, National University of Singapore, 3 Science Drive 3, 117543, Singapore.
^B Medicinal Chemistry Program, Life Sciences Institute, National University of Singapore, Singapore.
^C Corresponding author. Email: chmlyx@nus.edu.sg





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Australian Journal of Chemistry 62(9) 951–955 http://dx.doi.org/10.1071/CH09137
Submitted: 10 March 2009 Accepted: 1 April 2009 Published online: 17 September 2009

Abstract

Chiral molecules containing sulfone groups are useful intermediates and have found wide applications in organic synthesis. In this account, recent progress in the use of vinyl sulfones as Michael acceptors in the asymmetric organocatalytic conjugate addition is summarized.