Modelling Copper Binding to the Amyloid-β Peptide in Alzheimer

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Contents Vol 63(3)

doi:10.1071/CH09454

Modelling Copper Binding to the Amyloid-β Peptide in Alzheimer’s Disease

V. Chandana Epa ^A ^B, Victor A. Streltsov ^A, Joseph N. Varghese ^A

^A CSIRO Molecular and Health Technologies and Preventative Health Flagship, 343 Royal Parade, Parkville, Vic. 3052, Australia.
^B Corresponding author. Email: vidana.epa@csiro.au





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Australian Journal of Chemistry 63(3) 345–349 http://dx.doi.org/10.1071/CH09454
Submitted: 31 August 2009 Accepted: 4 January 2010 Published online: 26 March 2010

Abstract

Oxidative modification due to reactive oxygen species generated by Cu²⁺ bound to the amyloid-β peptide may be one of the sources of neurodegeneration observed in Alzheimer’s disease. Understanding the structure and function of the copper binding site can assist in the design of effective therapeutics. This paper highlights some of the most significant recent developments in computational modelling studies of the structure of the binding site and reaction mechanisms of reactive oxygen species generation.