A Simple One-Pot, Three Component Synthesis of 3-Arylpyrimido[4,5-c]pyridazine-5,7(6H,8H)-diones and their Sulfur Analogues as Potential Monoamine Oxidase Inhibitors

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Contents Vol 63(3)

doi:10.1071/CH09569

A Simple One-Pot, Three Component Synthesis of 3-Arylpyrimido[4,5-c]pyridazine-5,7(6H,8H)-diones and their Sulfur Analogues as Potential Monoamine Oxidase Inhibitors

Mehdi Rimaz ^A, Jabbar Khalafy ^A ^C, Nader Noroozi Pesyan ^A, Rolf H. Prager ^B

^A Chemistry Department, Urmia University, Urmia 57154, Iran.
^B School of Chemistry, Physics and Earth Sciences, Flinders University, Adelaide, SA 5001, Australia.
^C Corresponding author. Email: j.khalafi@mail.urmia.ac.ir; jkhalafi@yahoo.com





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Australian Journal of Chemistry 63(3) 507–510 http://dx.doi.org/10.1071/CH09569
Submitted: 27 October 2009 Accepted: 18 January 2010 Published online: 26 March 2010

Abstract

Several new 3-arylpyrimido[4,5-c]pyridazine-5,7(6H,8H)-diones and 3-aryl-5-oxo-7-thioxo-7,8-dihydropyrimido[4,5-c]pyridazin-5(6H)-ones have been synthesized by a three-component reaction of barbituric acid or thiobarbituric acid with arylglyoxals in the presence of a catalytic amount of pyridine and hydrazine hydrate at room temperature in water.