pH-Responsive Chiral Nanostructures
Jianzhong Du A B , Helen Willcock A , Nga Sze Ieong A and Rachel K. O'Reilly A C
+ Author Affiliations
- Author Affiliations
A University of Warwick, Department of Chemistry, Gibbet Hill Road, Coventry, CV7 4AL, UK.
B Current address: School of Materials Science and Engineering, Tongji University, 1239 Siping Road, Shanghai, China.
C Corresponding author. Email: R.K.O-Reilly@warwick.ac.uk
Australian Journal of Chemistry 64(8) 1041-1046 https://doi.org/10.1071/CH11131
Submitted: 5 April 2011 Accepted: 29 May 2011 Published: 19 August 2011
Abstract
There is great current interest in the design of robust synthetic polymers for the preparation of novel functional, well-defined, biocompatible and tailorable materials for a range of possible applications. In this work we have used reversible addition fragmentation chain transfer (RAFT) polymerization to prepare chiral and responsive amphiphilic block copolymers (based on polyphenylalanine acrylamide), which can be assembled at different pHs to form well-defined nanostructures. The morphology and size of the derived block polymers were explored using TEM, DLS and SLS measurements, while stability was examined by fluorescence and NMR spectroscopy. The application of these chiral and responsive nanostructures in the resolution of hydrophilic racemic amino acids has also been explored.
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