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Article << Previous     |     Next >>   Contents Vol 66(1)

Synthesis, Antimicrobial Activity, and Molecular Docking Study of Some Novel Cyclophanes with Imino Intra-Annular Functionality

Perumal Rajakumar A E , Ramar Padmanabhan B , Chandrasekaran Ramprasath C , Narayanasamy Mathivanan C , Vaidhyanathan Silambarasan D and Devadasan Velmurugan D

A Department of Organic Chemistry, University of Madras, Guindy Campus, Chennai, 600 025, India.
B Research and Development Centre, Orchid Chemicals and Pharmaceuticals Ltd, Sozhanganallur, Chennai, 600 119, India.
C Center for Advanced Studies in Botany, University of Madras, Guindy Campus, Chennai, 600 025, India.
D Center for Advanced Studies in Crystallography and Biophysics, University of Madras, Guindy Campus, Chennai, 600 025, India.
E Corresponding author. Email: perumalrajakumar@gmail.com

Australian Journal of Chemistry 66(1) 84-92 http://dx.doi.org/10.1071/CH12326
Submitted: 11 July 2012  Accepted: 14 August 2012   Published: 12 September 2012


 
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Abstract

The synthesis and structural characterisation of novel imino cyclophanes incorporating various spacer units is described. All the imino cyclophanes exhibit comparable antibacterial activity against Gram positive (Bacillus subtillus, Staphylococcus aureus) and Gram negative (Escherchia coli, Klebsiella pneumonia) bacterial strains. The imino cyclophanes also exhibit good antifungal activity against human pathogenic fungus, Candida albicans.





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