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Synthesis and Self-Assembly of a Peptide–Amphiphile as a Drug Delivery Vehicle
Soo Jung
Son A,
Margaret A.
Brimble A D,
Sunghyun
Yang A,
Paul W. R.
Harris A,
Tom
Reddingius A,
Benjamin W.
Muir B,
Oliver E.
Hutt B,
Lynne
Waddington B,
Jian
Guan C and
G. Paul
Savage B D
A
School of Chemical Sciences, The University of Auckland, 23 Symonds Street, Auckland 1010, New Zealand.
B
CSIRO Materials Science and Engineering, Bayview Avenue, Clayton, Vic. 3168, Australia.
C
Liggins Institute, Faculty of Medicince, The University of Auckland, 23 Symonds Street, Auckland 1010, New Zealand.
D
Corresponding authors. Email: m.brimble@auckland.ac.nz; paul.savage@csiro.au
Australian Journal of Chemistry
66(1)
23-29 http://dx.doi.org/10.1071/CH12347
Submitted: 23 July 2012 Accepted: 9 October 2012 Published:
12
November
2012
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Abstract
The formation of functional liposomes by the self assembly of a peptide–amphiphile that comprises the neuroprotective tripeptide motif glycyl-prolyl-glutamic acid linked to a hydrophobic moiety is reported. The self-assembled peptide–lipid conjugate displays long range order and can be dispersed as nanometre sized particles. 
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