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Continuous Flow Synthesis of Organic Electronic Materials – Case Studies in Methodology Translation and Scale-up
Helga
Seyler A,
Stefan
Haid B,
Tae-Hyuk
Kwon A C,
David J.
Jones A,
Peter
Bäuerle B,
Andrew B.
Holmes A and
Wallace W. H.
Wong A D
A
School of Chemistry, Bio21 Institute, University of Melbourne, Vic. 3010, Australia.
B
Institute of Organic Chemistry II and Advanced Materials, University of Ulm, Albert-Einstein-Allee 11, D-89081 Ulm, Germany.
C
Current address: Interdisciplinary School of Green Energy, Ulsan National Institute of Science and Technology, UNIST-gil 50, Eonyang-eup, Ulju-gun, Ulsan 689-798, Republic of Korea.
D
Corresponding author. Email: wwhwong@unimelb.edu.au
Australian Journal of Chemistry
66(2)
151-156 http://dx.doi.org/10.1071/CH12406
Submitted: 1 September 2012 Accepted: 3 October 2012 Published:
19
November
2012
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Abstract
The continuous flow synthesis of functional thiophene derivatives was examined. Methodology for the lithiation of thiophene building blocks was developed using a commercial bench-top flow reactor. In addition, the advantages of flow processing were demonstrated in the synthesis of a high performance organic dye in gram scale. 
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