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Australian Journal of Chemistry Australian Journal of Chemistry Society
An international journal for chemical science
RESEARCH ARTICLE

An Efficient and Convenient Approach for the Synthesis of Novel Pyrazolo[1,2-a]triazole-triones and Evaluation of their Antimicrobial Activities

Pooja Saluja A , Jitender M. Khurana A C , Chetan Sharma B and Kamal R. Aneja B
+ Author Affiliations
- Author Affiliations

A Department of Chemistry, University of Delhi, Delhi 110007, India.

B Department of Microbiology, Kurukshetra University, Kurukshetra 136119, Haryana, India.

C Corresponding author. Email: jmkhurana1@yahoo.co.in

Australian Journal of Chemistry 67(6) 867-874 https://doi.org/10.1071/CH13586
Submitted: 30 October 2013  Accepted: 24 January 2014   Published: 19 February 2014

Abstract

A new protocol for the efficient synthesis of novel pyrazolo[1,2-a]triazole-1,3,5-triones has been developed. The synthesis was achieved by reaction of aromatic aldehydes, Meldrum’s acid, and 4-phenylurazole in the presence of a catalytic amount of glacial AcOH at 80°C. The structural assignment has been unambiguously confirmed by X-ray analysis. The present finding provides an environmentally benign, efficient, and promising synthetic strategy for the synthesis of libraries with diversity. These compounds were tested in vitro for their antibacterial activity against four strains, namely Staphylococcus aureus, Bacillus subtilis, Escherichia coli, and Pseudomonas aeruginosa and antifungal activity against two fungal strains, namely Aspergillus niger and Aspergillus flavus.


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