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RESEARCH ARTICLE
Contents Vol 67(10)

Efficient Synthesis of 2-Imidazolines in the Presence of Molecular Iodine Under Ultrasound Irradiation

Guo-Feng Chen A D , Hong-Yang Li A , Nan Xiao A , Bao-Hua Chen B , Ya-Li Song B , Ji-Tai Li A and Zhi-Wei Li C
+ Author Affiliations
- Author Affiliations

A Key Laboratory of Chemical Biology of Hebei Province, College of Chemistry and Environmental Science, Hebei University, Baoding 071002, China.

B College of Pharmaceutical Sciences, Hebei University, Baoding 071002, China.

C College of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, Shijiazhuang 050018, China.

D Corresponding author. Email: chenguofeng@hbu.cn

Australian Journal of Chemistry 67(10) 1516-1521 https://doi.org/10.1071/CH13700
Submitted: 18 December 2013  Accepted: 3 March 2014   Published: 19 March 2014

Abstract

An efficient one-pot synthesis process for preparing 2-imidazolines from aldehydes and ethylenediamine using molecular iodine and potassium carbonate in absolute ethanol at 25–30°C under ultrasound irradiation is described. The synthetic strategy has the following advantages: mild conditions and low costs requirements, readily available catalyst, short reaction times, simplicity of operation, and good-to-excellent yields.


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