Insect Moulting Hormones: A Study of 4-En-3-one Steroids as Possible Ecdysteroid Precursors.
J Kinnear, M Martin, A Faux, DS Horn and J Wilkie
Australian Journal of Chemistry
32(9) 2019 - 2024
The trienol ether (15) of cholesta-4,7-dien-3-one (4) is oxidized with peroxy acid mainly to the 6-hydroxy derivatives (6) and (7) and the corresponding cholesta-4,7-diene-3,6-dione (8). However, the biosynthesis of ecdysteroids may not proceed by a similar pathway since the labelled keto diene (5) was not incorporated into 20-hydroxyecdysone (10) in Calliphora stygia. None of the possible 4-en-3-one ecdysteroid precursors synthesized (6), (7), (8), (18) were active in the Calliphora assay.
Full text doi:10.1071/CH9792017
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