Studies on reductive alkylation. A highly efficient synthesis of the phytoalexin orchinol
MJ Gunter and LN Mander
Australian Journal of Chemistry
34(3) 675 - 678
Reductive alkylation of 2,5-dimethoxybenzoic acid (1) with 2-(3',5'-dimethoxyphenyl)ethyl iodide (2) followed by cyclodehydration and oxidative decarboxylation afforded orchinol (5) in high overallyield. A simple synthesis of iodide (2) based on the reductive alkylation of 3,5-dimethoxybenzoic acid (6) was also developed.
Full text doi:10.1071/CH9810675
© CSIRO 1981