Molecular genetics is a maturing discipline with innovations that are finding application in animal breeding. Currently, DNA tests are available for parent identification or verification, and markers tests also exist for quantitative trait loci affecting important traits in beef cattle. The beef industry is, however, a particularly challenging industry in which to design breeding programs that fully capitalise on the potential of this technology. Hence, adoption within this industry to date has been below expectation. This paper examines several applications that are being investigated and will include discussion on issues constraining the transfer of DNA technology. An example of using DNA parentage testing for expanding the reach of selection programs into the commercial sector of the beef industry is explored in some depth, as it represents a potential high impact application. Use of molecular information in selection programs and in genetic evaluations is also discussed.