Grain growers in south-eastern Australia have reported unexpected crop failures with theoretically safe recropping periods for acetolactate synthase herbicides in alkaline soils. This experience has led to the concern that these herbicides may degrade very slowly in alkaline soils, and herbicide residues have at times been blamed for unexplained crop losses. To address this issue, we established 5 recropping trials across Victoria and South Australia with 5 acetolactate synthase herbicides (chlorsulfuron, triasulfuron, metsulfuron-methyl, imazethapyr, and flumetsulam). The herbicides were applied to separate plots in years 1, 2 or 3, and sensitive crop species were sown in year 4 to measure the impact of herbicide residues. We observed that the persistence of the sulfonylureas (chlorsulfuron, triasulfuron, metsulfuron-methyl) varied between herbicides, but all persisted longer in alkaline soils than in acid soils, and were, therefore, more likely to damage crops in alkaline soil. Imazethapyr persisted longer in clay soils than in sandy soils and was, therefore, more likely to damage crops in clay soils. All herbicides persisted longer when rainfall was below average. Canola was more sensitive to imazethapyr than either pea, lentil or medic, but was less sensitive to the sulfonylureas. In contrast, lentil and medic were the most sensitive to sulfonylureas. Despite some damage, we found that safe recropping periods could be predicted from the product labels in all but one situation. The sole exception was that metsulfuron-methyl reduced dry matter and yield of lentil and medic sown 10 months after application in a soil with pH 8.5. We hypothesise that the real cause of crop failure in many situations is not unusual herbicide persistence, but failure to take full account of soil type (pH and clay content including variation in the paddock) and rainfall when deciding to recrop after using acetolactate synthase herbicides.