The ‘Regional Combinations’ project and its biophysical outcomes have been described in several other papers in this special edition. The information provided in these papers allows an evaluation of the most profitable beef cattle production systems across different environments in southern Australia. In this paper, the focus is on the New South Wales experimental site where the trial animals were finished in a feedlot. The data identified liveweight gain as the biggest driver of profitability of production. Between growth treatments, there was a large difference in the gross margins before feedlot entry between the ‘fast’ and ‘slow’ treatments favouring the fast-grown animals, even after accounting for the higher cost of producing pasture capable of sustaining faster growth. However, the slow growth treatments consistently outperformed the fast growth treatments in the feedlot. In terms of breeds, the European breed types consistently outperformed the Wagyu breeds. There were no time-of-calving experiments in New South Wales.