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Australian Journal of Zoology Australian Journal of Zoology Society
Evolutionary, molecular and comparative zoology
REVIEW

Platypus venom: source of novel compounds

Jennifer M. S. Koh A , Paramjit S. Bansal B , Allan M. Torres C and Philip W. Kuchel A D
+ Author Affiliations
- Author Affiliations

A School of Molecular and Microbial Biosciences, Building G08, University of Sydney, NSW 2006, Australia.

B Australian Nuclear Science and Technology Organisation, Menai, NSW 2234, Australia.

C Nanoscale Organisation and Dynamics Group, College of Health and Science, University of Western Sydney, Penrith South DC, NSW 1797, Australia.

D Corresponding author. Email: p.kuchel@mmb.usyd.edu.au

Australian Journal of Zoology 57(4) 203-210 https://doi.org/10.1071/ZO09040
Submitted: 7 April 2009  Accepted: 30 July 2009   Published: 26 October 2009

Abstract

An anatomical feature of the platypus (Ornithorhynchus anatinus) that is seen in only one other mammal, the echidna, is that the male has a crural glandular system that produces venom that is used for defence and territorial–breeding functions; whether the echidna is similarly venomous is not yet established. Platypus venom contains many novel proteins and peptides that are different from those in reptilian venom. It also causes pain and symptoms that are not experienced by any other kind of envenomation. Five types of proteins and peptides have been isolated and identified from platypus venom, namely: defensin-like peptides (DLPs); Ornithorhynchus venom C-type natriuretic peptides (OvCNPs); Ornithorhynchus nerve growth factor; hyaluronidase; and l-to-d-peptide isomerase. The structures of DLPs and OvCNPs have already been studied and they are very similar to β-defensin-12 and mammalian C-type natriuretic peptides, respectively. A special mammalian l-to-d-peptide isomerase that is responsible for interconverting the l- and d-peptide isomers is also found in platypus venom. Isomerase activity has recently been discovered in platypus tissues other than the venom gland. It is possible that similar kinds of enzymes might exist in other mammals and play important, as yet unknown, biological roles. Considering the fact that some animal venoms have already been widely used in pharmaceutical applications, research into platypus venom may lead to the discovery of new molecules and potent drugs that are useful biomedical tools.

Additional keywords: peptides, peptide isomerase, structure.


Acknowledgements

The work was funded by an ARC Discovery Project Grant to PWK and Associate Professor J. I. Vandenberg. Dr Dom Geraghty is thanked for discussions and the supply of venom and venom glands. JMSK is supported by an Australian Postgraduate Award.


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