Prenatal origins of postnatal variation in growth, development and productivity of ruminants
Alan W. Bell A D and Paul L. Greenwood B C
+ Author Affiliations
- Author Affiliations
A Department of Animal Science, Cornell University, Ithaca, NY 14853-4801, USA.
B NSW Department of Primary Industries Beef Industry Centre, University of New England, Armidale, NSW 2351, Australia.
C CSIRO Agriculture Flagship, Armidale, NSW 2350, Australia.
D Corresponding author. Email: awb6@cornell.edu
Animal Production Science 56(8) 1217-1232 https://doi.org/10.1071/AN15408
Submitted: 25 July 2015 Accepted: 15 September 2015 Published: 25 February 2016
Abstract
This review provides an update on recent research into the effects of maternal nutrition on fetal biology and the growth, development and productivity of progeny in postnatal life of ruminant livestock. Evidence is summarised for effects on postnatal growth and body composition, feed intake and efficiency, carcass characteristics and meat quality, wool production, reproduction and lactation performance. In general, these demonstrated effects are not large in relation to the effects of postnatal nutrition and other environmental influences. The mechanisms underpinning the above production outcomes are briefly discussed in terms of systemic endocrine and metabolic responses, and cellular and molecular effects in skeletal muscle, bone, adipose tissue, wool follicles and brain of fetal, neonatal and adult progeny. Treatments observed to elicit tissue responses include maternal under- and overnutrition at various stages of pregnancy and placental insufficiency caused by increased litter size, chronic maternal heat stress and premating carunclectomy in sheep. The as yet meagre evidence for epigenetic mediation of intergenerational effects in ruminants is considered, as is the likelihood that other, more conventional explanations may suffice in some cases. Finally, evidence is summarised for the proposition that the placenta is not merely a passive conduit for nutrient transfer from dam to fetus, but plays an active role in buffering the effects of variations in maternal nutrition on fetal growth and development, and thence, postnatal outcomes.
Additional keywords: cattle, fetal development, sheep.
References
Asmad K, Kenyon PR, Pain SJ, Parkinson TJ, Peterson SW, Lopez-Villalobos N, Blair HT (2014) Effects of dam size and nutrition during pregnancy on lifetime performance of female offspring. Small Ruminant Research 121, 325–335.| Effects of dam size and nutrition during pregnancy on lifetime performance of female offspring.Crossref | GoogleScholarGoogle Scholar |
Barker DJP (2004) The developmental origins of chronic adult disease. Acta Paediatrica 446, 26–33.
Bawden CS, Kleemann DO, McLaughlan CJ, Nattrass GS, Dunn SM (2010) Mechanistic aspects of fetal development relating to postnatal fibre production and follicle development in ruminants. In ‘Managing the prenatal environment to enhance livestock productivity’. (Eds PL Greenwood, AW Bell, PE Vercoe, GJ Viljoen) pp. 121–159. (Springer: Dordrecht, The Netherlands)
Behrendt R, van Burgel AJ, Bailey A, Barber P, Curnow M, Gordon DJ, Hocking Edwards JE, Oldham CM, Thompson AN (2011) On-farm paddock-scale comparisons across southern Australia confirm that increasing the nutrition of Merino ewes improves their production and the lifetime performance of their progeny. Animal Production Science 51, 805–812.
| On-farm paddock-scale comparisons across southern Australia confirm that increasing the nutrition of Merino ewes improves their production and the lifetime performance of their progeny.Crossref | GoogleScholarGoogle Scholar |
Bell AW (1992) Foetal growth and its influence on postnatal growth and development. In ‘The control of fat and lean deposition’. (Eds PJ Buttery, KN Boorman, DB Lindsay) pp. 111–127. (Butterworth-Heineman: Oxford, UK)
Bell AW, Ehrhardt RA (2002) Regulation of placental nutrient transport and implications for fetal growth. Nutrition Research Reviews 15, 211–230.
| Regulation of placental nutrient transport and implications for fetal growth.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD38Xps1Kls7s%3D&md5=d8d8e1544523c6cab0c7f7f203481dcaCAS | 19087405PubMed |
Bell AW, Greenwood PL, Ehrhardt RA (2005) Regulation of metabolism and growth during prenatal life. In ‘Biology of metabolism in growing animals’. (Eds DG Burrin, HJ Mersmann) pp. 3–34. (Elsevier: London)
Bielli A, Perez R, Pedrana G, Milton JTB, Lopez A, Blackberry MA, Duncombe G, Rodriguez-Martinez H, Martin GB (2002) Low maternal nutrition during pregnancy reduces the number of sertoli cells in the newborn lamb. Reproduction, Fertility and Development 14, 333–337.
| Low maternal nutrition during pregnancy reduces the number of sertoli cells in the newborn lamb.Crossref | GoogleScholarGoogle Scholar |
Blair HT, Jenkinson CMC, Peterson SW, Kenyon PR, van der Linden DS, Davenport LC, Mackenzie DDS, Morris ST, Firth EC (2010) Dam and granddam feeding during pregnancy in sheep affects milk supply in offspring and reproductive performance in grand-offspring. Journal of Animal Science 88, E40–E50.
| Dam and granddam feeding during pregnancy in sheep affects milk supply in offspring and reproductive performance in grand-offspring.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DC%2BC3c3pslyrtQ%3D%3D&md5=25662ba12ab87e664fa2df3fc6910766CAS | 19966171PubMed |
Blair HT, van der Linden DS, Jenkinson CMC, Morris ST, Mackenzie DDS, Peterson SW, Firth EC, Kenyon PR (2011) Do ewe size and nutrition during pregnancy affect foetus and foetal organ weight in twins? Livestock Science 142, 99–107.
| Do ewe size and nutrition during pregnancy affect foetus and foetal organ weight in twins?Crossref | GoogleScholarGoogle Scholar |
Brameld JM, Greenwood PL, Bell AW (2010) Biological mechanisms of fetal development relating to postnatal growth, efficiency and carcass characteristics in ruminants. In ‘Managing the prenatal environment to enhance livestock productivity’. (Eds PL Greenwood, AW Bell, PE Vercoe, GJ Viljoen) pp. 93–119. (Springer: Dordrecht, The Netherlands)
Byrne K, McWilliam S, Vuocolo T, Gondro C, Cockett NE, Tellam RL (2014) Genomic architecture of histone 3 lysine 27 trimethylation during late ovine skeletal muscle development. Animal Genetics 45, 427–438.
| Genomic architecture of histone 3 lysine 27 trimethylation during late ovine skeletal muscle development.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC2cXmtFSkt7c%3D&md5=1bb521cd4cfe6a44b093e837d1dafeabCAS | 24673416PubMed |
Cafe LM, Hennessy DW, Hearnshaw H, Morris SG, Greenwood PL (2009) Consequences of prenatal and preweaning growth for feedlot growth, intake and efficiency of Piedmontese- and Wagyu-sired cattle. Animal Production Science 49, 461–467.
| Consequences of prenatal and preweaning growth for feedlot growth, intake and efficiency of Piedmontese- and Wagyu-sired cattle.Crossref | GoogleScholarGoogle Scholar |
Canani RB, Di Costanzo M, Leone L, Bedogni G, Brambilla B, Cianfarani S, Nobili V, Pietrobelli A, Agostoni C (2011) Epigenetic mechanisms elicited by nutrition in early life. Nutrition Research Reviews 24, 198–205.
| Epigenetic mechanisms elicited by nutrition in early life.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC38Xhslyns7c%3D&md5=1e7e3a3ff6153fe8f55e0cbc308839e3CAS | 22008232PubMed |
Capuco AV, Akers RM (2010) Management and environmental influences on mammary gland development and milk production. In ‘Managing the prenatal environment to enhance livestock productivity’. (Eds PL Greenwood, AW Bell, PE Vercoe, GJ Viljoen) pp. 259–292. (Springer: Dordrecht, The Netherlands)
Capuco AV, Ellis SE (2013) Comparative aspects of mammary gland development and homeostasis. Annual Review of Animal Biosciences 1, 179–202.
| Comparative aspects of mammary gland development and homeostasis.Crossref | GoogleScholarGoogle Scholar | 25387016PubMed |
Chavatte-Palmer P, Dupont C, Debus N, Camous S (2014) Nutritional programming and the reproductive function of the offspring. Animal Production Science 54, 1166–1176.
Coan PM, Vaughan OR, Sekita Y, Finn SL, Burton GJ, Constancia M, Fowden AL (2010) Adaptations in placental phenotype support fetal growth during undernutrition of pregnant mice. The Journal of Physiology 588, 527–538.
| Adaptations in placental phenotype support fetal growth during undernutrition of pregnant mice.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3cXhvV2js7o%3D&md5=574aedd3523cd662800a1f4ca678efccCAS | 19948659PubMed |
Cripps RL, Green LR, Thompson J, Martin-Gronert MS, Monk M, Sheldon IM, Hanson MA, Hales CN, Ozanne SE (2008) The effect of maternal body condition score before and during pregnancy on the glucose tolerance of adult sheep offspring. Reproductive Sciences 15, 448–456.
| The effect of maternal body condition score before and during pregnancy on the glucose tolerance of adult sheep offspring.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1cXoslOqur8%3D&md5=d88e36b96c4df739b78a3584b674c448CAS | 18332237PubMed |
Da Silva P, Aitken RP, Rhind SM, Racey PA, Wallace JM (2001) Influence of placentally mediated fetal growth restriction on the onset of puberty in male and female lambs. Reproduction 122, 375–383.
| Influence of placentally mediated fetal growth restriction on the onset of puberty in male and female lambs.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD3MXntVGksLY%3D&md5=9972439aea93766d0e718900de4a588dCAS | 11597303PubMed |
Da Silva P, Aitken RP, Rhind SM, Racey PA, Wallace JM (2002) Impact of maternal nutrition during pregnancy on pituitary gonadotrophin gene expression and ovarian development in growth-restricted and normally grown late gestation sheep fetuses. Reproduction 123, 769–777.
| Impact of maternal nutrition during pregnancy on pituitary gonadotrophin gene expression and ovarian development in growth-restricted and normally grown late gestation sheep fetuses.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD38XkvVCiur8%3D&md5=e65735841fa203468e4646745ccbeb79CAS | 12052231PubMed |
Da Silva P, Aitken RP, Rhind SM, Racey PA, Wallace JM (2003) Effect of maternal overnutrition during pregnancy on pituitary gonadotrophin gene expression and gonadal morphology in female and male foetal sheep at day 103 of gestation. Placenta 24, 248–257.
| Effect of maternal overnutrition during pregnancy on pituitary gonadotrophin gene expression and gonadal morphology in female and male foetal sheep at day 103 of gestation.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD3sXptlOltA%3D%3D&md5=c1b9513d5406e3b64b3ed5634c90e0e0CAS | 12566252PubMed |
De Blasio MJ, Gatford KL, McMillen IC, Robinson JS, Owens JA (2007a) Placental restriction of fetal growth increases insulin action, growth, and adiposity in the young lamb. Endocrinology 148, 1350–1358.
| Placental restriction of fetal growth increases insulin action, growth, and adiposity in the young lamb.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2sXitlWntr8%3D&md5=d5b5842d567e5098f7ea8dc624f00359CAS | 17110432PubMed |
De Blasio MJ, Gatford KL, Robinson JS, Owens JA (2007b) Placental restriction of fetal growth reduces size at birth and alters postnatal growth, feeding activity, and adiposity in the young lamb. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology 292, R875–R886.
| Placental restriction of fetal growth reduces size at birth and alters postnatal growth, feeding activity, and adiposity in the young lamb.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2sXjt1Gmsr8%3D&md5=d46c62f83f03613cb967caf100a97546CAS | 17023666PubMed |
Dellschaft NS, Alexandre-Gouabau M-C, Gardner DS, Antignac J-P, Keisler DH, Budge H, Symonds ME, Sebert SP (2015) Effect of pre- and postnatal growth and post-weaning activity on glucose metabolism in the offspring. The Journal of Endocrinology 224, 171–182.
| Effect of pre- and postnatal growth and post-weaning activity on glucose metabolism in the offspring.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC2MXmtV2mt7Y%3D&md5=dc2cf730d76c42fd4ee3e92ed9ab10d9CAS | 25416820PubMed |
Dobos RC, Nandra KS, Riley K, Fulkerson WJ, Lean IJ, Kellaway RC (2001) Effects of age and liveweight at first calving on first lactation milk, protein and fat yield of Friesian heifers. Australian Journal of Experimental Agriculture 41, 13–19.
| Effects of age and liveweight at first calving on first lactation milk, protein and fat yield of Friesian heifers.Crossref | GoogleScholarGoogle Scholar |
Dobos RC, Nandra KS, Riley K, Fulkerson WJ, Alford A, Lean IJ (2004) Effects of age and liveweight of dairy heifers at first calving on multiple lactation production. Australian Journal of Experimental Agriculture 44, 969–974.
| Effects of age and liveweight of dairy heifers at first calving on multiple lactation production.Crossref | GoogleScholarGoogle Scholar |
Donovan EL, Hernandez CE, Matthews LR, Oliver MH, Jaquiery AL, Bloomfield FH, Harding JE (2013) Periconceptual undernutrition in sheep leads to decreased locomotor activity in a natural environment. Journal of Developmental Origins of Health and Disease 4, 296–299.
| Periconceptual undernutrition in sheep leads to decreased locomotor activity in a natural environment.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3sXhtVOkurjE&md5=6038db3975d00182432039e7cf13dfc1CAS | 24993003PubMed |
Du M, Tong J, Zhao J, Underwood KR, Zhu M, Ford SP, Nathanielsz PW (2010) Fetal programming of skeletal muscle development in ruminants. Journal of Animal Science 88, E51–E60.
| Fetal programming of skeletal muscle development in ruminants.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DC%2BC3c3pslOisw%3D%3D&md5=bbbe15a77407c1f7b69b12e26ca594e2CAS | 19717774PubMed |
Du M, Wang B, Fu X, Yang Q, Zhu M-J (2015) Fetal programming in meat production. Meat Science 109, 40–47.
| Fetal programming in meat production.Crossref | GoogleScholarGoogle Scholar | 25953215PubMed |
Duffield JA, Vuocolo T, Tellem R, Yuen BS, Muhlhausler BS, McMillen IC (2008) Placental restriction of fetal growth decreases IGF1 and leptin mRNA expression in the perirenal adipose tissue of late gestation fetal sheep. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology 294, R1413–R1419.
| Placental restriction of fetal growth decreases IGF1 and leptin mRNA expression in the perirenal adipose tissue of late gestation fetal sheep.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1cXmtVWnsL0%3D&md5=c33f9fcc0bfe22f1b4b507518966c31cCAS | 18272661PubMed |
Duncan JR, Cock ML, Loeliger M, Louey S, Harding R, Rees SM (2004) Effects of exposure to chronic placental insufficiency in sheep on the postnatal brain and retina. Journal of Neuropathology and Experimental Neurology 63, 1131–1143.
Ehrhardt RA (1997) Regulation of glucose transport and partitioning by the placenta in the second half of pregnancy in sheep. PhD Thesis, Cornell University, Ithaca, NY.
Ehrhardt RA, Boston RC, Slepetis RM, Bell AW (1996) Moderate maternal undernutrition elevates placental glucose transport capacity in sheep. Journal of Animal Science 74, 152
Ehrhardt RA, Slepetis RM, Bell AW (1998) Moderate maternal undernutrition alters glucoes transporter levels in maternal insulin-responsive tissues and in the placenta. Journal of Animal Science 76, 130
Everitt GC (1968) Prenatal development of uniparous animals, with particular reference to the influence of maternal nutrition in sheep. In ‘Growth and development of mammals’. (Eds GA Lodge, GE Lamming) pp. 131–157. (Butterworths: London)
Field ME, Anthony RV, Engle TE, Archibeque SL, Keisler DH, Han H (2015) Duration of maternal undernutrition differentially alters fetal growth and hormone concentrations. Domestic Animal Endocrinology 51, 1–7.
| Duration of maternal undernutrition differentially alters fetal growth and hormone concentrations.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC2cXhs1ymu7bI&md5=6edc7fdc18bab0e204a4d0cbd23554c6CAS | 25460066PubMed |
Firth EC, Rogers CW, Vickers M, Kenyon PR, Jenkinson CMC, Blair HT, Johnson PL, Mackenzie DS, Peterson SW, Morris ST (2008) The bone-muscle ratio of fetal lambs is affected more by maternal nutrition during pregnancy than by maternal size. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology 294, R1890–R1894.
| The bone-muscle ratio of fetal lambs is affected more by maternal nutrition during pregnancy than by maternal size.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1cXnsVarsrs%3D&md5=ea5a56173b41f4766dcc71063375199cCAS | 18385462PubMed |
Fletcher CJ, Roberts CT, Hartwich KM, Walker SK, McMillen IC (2007) Somatic cell nuclear transfer induces placental defects that likely precede fetal demise. Reproduction (Cambridge, England) 133, 243–255.
| Somatic cell nuclear transfer induces placental defects that likely precede fetal demise.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2sXjs1aisrg%3D&md5=87196607d7ab9cf471f0e7b2d7d17977CAS |
Ford SP, Long NM (2012) Evidence for similar changes in offspring phenotype following either maternal undernutrition or overnutrition: potential impact on fetal epigenetic mechanisms. Reproduction, Fertility and Development 24, 105–111.
| Evidence for similar changes in offspring phenotype following either maternal undernutrition or overnutrition: potential impact on fetal epigenetic mechanisms.Crossref | GoogleScholarGoogle Scholar |
Ford SP, Hess BW, Schwope MM, Nijland MJ, Gilbert JS, Vonnahme KA, Means WJ, Han H, Nathanielsz PW (2007) Maternal undernutrition during early to mid-gestation in the ewe results in altered growth, adiposity, and glucose tolerance in male offspring. Journal of Animal Science 85, 1285–1294.
| Maternal undernutrition during early to mid-gestation in the ewe results in altered growth, adiposity, and glucose tolerance in male offspring.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2sXksF2hur8%3D&md5=6efdf99f57ed85ca59d35d0207f7d373CAS | 17224460PubMed |
Forhead AJ, Fowden AL (2014) Thyroid hormones in fetal growth and prepartum maturation. The Journal of Endocrinology 221, R87–R103.
| Thyroid hormones in fetal growth and prepartum maturation.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC2cXhtFOnurjP&md5=d99fbf8d284252414844907b4988537bCAS | 24648121PubMed |
Fowden AL, Giussani DA, Forhead AJ (2005) Endocrine and metabolic programming during intrauterine development. Early Human Development 81, 723–734.
| Endocrine and metabolic programming during intrauterine development.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2MXpvV2mtrg%3D&md5=a196bd52c6dc6db2ccc810a0a19825a6CAS | 16085373PubMed |
Fowden AL, Coan PM, Angiolini E, Burton GJ, Constancia M (2011) Imprinted genes and the epigenetic regulation of placental phenotype. Progress in Biophysics and Molecular Biology 106, 281–288.
| Imprinted genes and the epigenetic regulation of placental phenotype.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3MXntFKgtrk%3D&md5=f2870c497e4049c84be3680e88e82577CAS | 21108957PubMed |
Funston RN, Summers AF (2013) Epigenetics: setting up lifetime production of beef cows by managing nutrition. Annual Review of Animal Biosciences 1, 339–363.
| Epigenetics: setting up lifetime production of beef cows by managing nutrition.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DC%2BC2M3ntlOgtA%3D%3D&md5=9eeddf25adc4bba5c3aa002fa3037b90CAS | 25387023PubMed |
Gardner DS, Tingey K, Van Bon TWM, Ozanne SE, Wilson V, Dandrea K, Keisler DH, Stephenson T, Symonds ME (2005) Programming of glucose-insulin metabolism in adult sheep after maternal undernutrition. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology 289, R947–R954.
| Programming of glucose-insulin metabolism in adult sheep after maternal undernutrition.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2MXhtFensb7I&md5=e5883c52902a74ea4334b649c78d7163CAS | 15961536PubMed |
George LA, Uthlaut AB, Long NM, Zhang L, Ma Y, Smith DT, Nathanielsz PW, Ford SP (2010) Different levels of overnutrition and weight gain during pregnancy have differential effects on fetal growth and organ development. Reproductive Biology and Endocrinology 8, 75
| Different levels of overnutrition and weight gain during pregnancy have differential effects on fetal growth and organ development.Crossref | GoogleScholarGoogle Scholar | 20576133PubMed |
Goddard ME, Whitelaw E (2014) The use of epigenetic phenomena for the improvement of sheep and cattle. Frontiers in Genetics 5, article 217
| The use of epigenetic phenomena for the improvement of sheep and cattle.Crossref | GoogleScholarGoogle Scholar |
Greenwood PL, Bell AW (2003a) Prenatal influences on growth and development of ruminants. Recent Advances in Animal Nutrition in Australia 14, 57–73.
Greenwood PL, Bell AW (2003b) Consequences of intra-uterine growth retardation for postnatal growth, metabolism and pathophysiology. Reproduction (Cambridge, England) Supplement 61, 195–206.
Greenwood PL, Bell AW (2014) Consequences of nutrition during gestation, and the challenge to better understand and enhance livestock productivity and efficiency in pastoral ecosystems. Animal Production Science 54, 1109–1118.
Greenwood PL, Hunt AS, Hermanson JW, Bell AW (1998) Effects of birth weight and postnatal nutrition on neonatal sheep: I. Body growth and composition, and some aspects of energetic efficiency. Journal of Animal Science 76, 2354–2367.
Greenwood PL, Slepetis RM, Hermanson JW, Bell AW (1999) Intrauterine growth retardation is associated with reduced cell cycle activity, but not myofibre number, in ovine fetal muscle. Reproduction, Fertility and Development 11, 281–291.
| Intrauterine growth retardation is associated with reduced cell cycle activity, but not myofibre number, in ovine fetal muscle.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DC%2BD3czovFentA%3D%3D&md5=7fcd3da2b7ce1ce79ce5a8d2cb4e16efCAS |
Greenwood PL, Hunt AS, Hermanson JW, Bell AW (2000) Effects of birth weight and postnatal nutrition on neonatal sheep: II. Skeletal muscle growth and development. Journal of Animal Science 78, 50–61.
Greenwood PL, Hunt AS, Slepetis RM, Finnerty KD, Alston C, Beermann SH, Bell AW (2002) Effects of birth weight and postnatal nutrition on neonatal sheep: III. Regulation of energy metabolism. Journal of Animal Science 80, 2850–2861.
Greenwood PL, Cafe LM, Hearnshaw H, Hennessy DW, Thompson JM, Morris SG (2006) Long-term consequences of birth weight and growth to weaning on carcass, yield and beef quality characteristics of Piedmontese- and Wagyu-sired cattle. Australian Journal of Experimental Agriculture 46, 257–269.
| Long-term consequences of birth weight and growth to weaning on carcass, yield and beef quality characteristics of Piedmontese- and Wagyu-sired cattle.Crossref | GoogleScholarGoogle Scholar |
Greenwood PL, Cafe LM, Hearnshaw H, Hennessy DW, Morris SG (2009) Consequences of prenatal and preweaning growth for yield of primal cuts from 30 month-old Piedmontese- and Wagyu-sired cattle. Animal Production Science 49, 468–478.
| Consequences of prenatal and preweaning growth for yield of primal cuts from 30 month-old Piedmontese- and Wagyu-sired cattle.Crossref | GoogleScholarGoogle Scholar |
Greenwood PL, Thompson AN, Ford SP (2010) Postnatal consequences of the maternal environment and growth during prenatal life for productivity of ruminants. In ‘Managing the prenatal environment to enhance livestock productivity’. (Eds PL Greenwood, AW Bell, PE Vercoe, GJ Viljoen) pp. 3–36. (Springer: Dordrecht, The Netherlands)
Hammond J (1944) Physiological factors affecting birth weight. The Proceedings of the Nutrition Society 2, 8–12.
Hocking Edwards JE, Hocking KJ, Thompson AN (2011) Managing the nutrition of twin-bearing ewes during pregnancy using Lifetimewool recommendations increases production of twin lambs. Animal Production Science 51, 813–820.
| Managing the nutrition of twin-bearing ewes during pregnancy using Lifetimewool recommendations increases production of twin lambs.Crossref | GoogleScholarGoogle Scholar |
Hopkins PS, Thorburn GD (1972) The effects of foetal thyroidectomy on the development of the ovine foetus. The Journal of Endocrinology 54, 55–66.
| The effects of foetal thyroidectomy on the development of the ovine foetus.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaE38XksVKit74%3D&md5=d699fcdef6c99fc21386b4f5900d7de2CAS | 5065283PubMed |
Huang Y, Das AK, Yang Q-Y, Zhu M-J, Du M (2012) Zfp423 promotes adipogenic differentiation of bovine stromal vascular cells. PLoS One 7, e47496
| Zfp423 promotes adipogenic differentiation of bovine stromal vascular cells.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC38XhsFOku7jE&md5=ffa8c87b06c2e3c2ee27a7f54a94048bCAS | 23071815PubMed |
Jaquiery AL, Oliver MH, Bloomfield FH, Harding JE (2011) Periconceptual events perturb postnatal growth regulation in sheep. Pediatric Research 70, 261–266.
| Periconceptual events perturb postnatal growth regulation in sheep.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3MXhtVSgu7vK&md5=cf9a80855247bfd0c422cac5a37f1a78CAS | 21587096PubMed |
Jaquiery AL, Oliver MH, Honeyfield-Ross M, Harding JE, Bloomfield FH (2012) Periconceptual undernutrition in sheep affects adult phenotype only in males. Journal of Nutrition and Metabolism 2012, 123610
| Periconceptual undernutrition in sheep affects adult phenotype only in males.Crossref | GoogleScholarGoogle Scholar | 23091706PubMed |
Kelly RW, Greeff JC, Macleod I (2006) Lifetime changes in wool production of Merino sheep following differential feeding in fetal and early life. Australian Journal of Agricultural Research 57, 867–876.
| Lifetime changes in wool production of Merino sheep following differential feeding in fetal and early life.Crossref | GoogleScholarGoogle Scholar |
Kenyon PR, Blair HT (2014) Foetal programming in sheep: effects on production. Small Ruminant Research 118, 16–30.
| Foetal programming in sheep: effects on production.Crossref | GoogleScholarGoogle Scholar |
Kenyon PR, Pain SJ, Hutton PG, Jenkinson CMC, Morris ST, Peterson SW, Blair HT (2011a) Effects of twin-bearing ewe nutritional treatments on ewe and lamb performance to weaning. Animal Production Science 51, 406–415.
| Effects of twin-bearing ewe nutritional treatments on ewe and lamb performance to weaning.Crossref | GoogleScholarGoogle Scholar |
Kenyon PR, van der Linden DS, Jenkinson DMC, Morris ST, Mackenzie DDS, Peterson SW, Firth EC, Blair HT (2011b) The effect of ewe size and nutritional regimen beginning in early pregnancy on development of singleton foetuses in late pregnancy. Livestock Science 142, 92–98.
| The effect of ewe size and nutritional regimen beginning in early pregnancy on development of singleton foetuses in late pregnancy.Crossref | GoogleScholarGoogle Scholar |
Kenyon PR, Corner-Thomas RA, Peterson SW, Pain SJ, Blair HT (2014) Pregnancy nutrition does not influence lamb liveweight in developmentally programmed ewes. Animal Production Science 54, 1465–1470.
| Pregnancy nutrition does not influence lamb liveweight in developmentally programmed ewes.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC2cXhtlaktLbJ&md5=69df9a032362be07ad03fa0a8a44e9dfCAS |
Knight CH, Sorensen A (2001) Windows in early mammary development: critical or not? Reproduction 122, 337–345.
| Windows in early mammary development: critical or not?Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD3MXntVGksLs%3D&md5=d1696f3110b96f720b4c6cfb37f05cb5CAS | 11597300PubMed |
Lanham SA, Fowden AL, Roberts C, Cooper C, Oreffo ROC, Forhead AJ (2011) Effects of hypothyroidism on the structure and mechanical properties of bone in the ovine fetus. The Journal of Endocrinology 210, 189–198.
| Effects of hypothyroidism on the structure and mechanical properties of bone in the ovine fetus.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3MXpvFeks7o%3D&md5=db5f0873ee868b1fa3271a3eed34b90bCAS | 21642376PubMed |
Larson DM, Martin JL, Adams DC, Funston RM (2009) Winter grazing system and supplementation during late gestation influence performance of beef cows and steer progeny. Journal of Animal Science 87, 1147–1155.
| Winter grazing system and supplementation during late gestation influence performance of beef cows and steer progeny.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1MXislaqs74%3D&md5=332c5458cc76d84e0bccf36670be2158CAS | 18997078PubMed |
Lassala A, Bazer FW, Cudd TA, Datta S, Keisler DH, Satterfield MC, Spencer TE, Wu G (2010) Parenteral administration of L-arginine prevents fetal growth restriction in undernourished ewes. The Journal of Nutrition 140, 1242–1248.
| Parenteral administration of L-arginine prevents fetal growth restriction in undernourished ewes.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3cXot1Cruro%3D&md5=6a1b9e800e134723cf1abc4377325388CAS | 20505020PubMed |
Lassala A, Bazer FW, Cudd TA, Datta S, Keisler DH, Satterfield MC, Spencer TE, Wu G (2011) Parenteral administration of L-arginine enhances fetal growth survival and growth in sheep carrying multiple fetuses. The Journal of Nutrition 141, 849–855.
| Parenteral administration of L-arginine enhances fetal growth survival and growth in sheep carrying multiple fetuses.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3MXltlCqtbo%3D&md5=4688f4db8f9149d94b75fa140aa7016bCAS | 21430253PubMed |
Lea RG, Andrade LP, Rae MT, Hannah LT, Kyle CE, Murray JF, Rhind SM, Miller DW (2006) Effects of maternal undernutrition during early pregnancy on apoptosis regulators in the ovine fetal ovary. Reproduction 131, 113–124.
| Effects of maternal undernutrition during early pregnancy on apoptosis regulators in the ovine fetal ovary.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD28XhsFegsrg%3D&md5=5a99b71197b6eab052d0a02ca5b48e29CAS | 16388015PubMed |
Long NM, George LA, Uthlaut AB, Smith DT, Nijland MJ, Nathanielsz PW, Ford SP (2010) Maternal obesity and increased nutrient intake before and during gestation in the ewe results in altered growth, adiposity, and glucose tolerance in adult offspring. Journal of Animal Science 88, 3546–3553.
| Maternal obesity and increased nutrient intake before and during gestation in the ewe results in altered growth, adiposity, and glucose tolerance in adult offspring.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3cXhtlGlsL7J&md5=8d9a73007f8e0b1a84a9a76d51101a96CAS | 20622177PubMed |
Long NM, Rule DC, Zhu MJ, Nathanielsz PW, Ford SP (2012) Maternal obesity upregulates fatty acid and glucose transporters and increases expression of enzymes mediating fatty acid biosynthesis in fetal adipose tissue depots. Journal of Animal Science 90, 2201–2210.
| Maternal obesity upregulates fatty acid and glucose transporters and increases expression of enzymes mediating fatty acid biosynthesis in fetal adipose tissue depots.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC38XhtFehsbrF&md5=6e9e56797c33adb9e916add16f39bc5bCAS | 22266999PubMed |
Louey S, Cock ML, Harding R (2005) Long term consequences of low birth weight on postnatal growth, adiposity and brain weight at maturity in sheep. The Journal of Reproduction and Development 51, 59–68.
| Long term consequences of low birth weight on postnatal growth, adiposity and brain weight at maturity in sheep.Crossref | GoogleScholarGoogle Scholar | 15750297PubMed |
Lutz L, Dufourny L, Skinner DC (2006) Effect of nutrient restriction on the somatotropes and substance P-immunoreactive cells in the pituitary of the female ovine fetus. Growth Hormone & IGF Research 16, 108–118.
| Effect of nutrient restriction on the somatotropes and substance P-immunoreactive cells in the pituitary of the female ovine fetus.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD28XkvVGjsrk%3D&md5=462e15614d99143f048c8654911d43a9CAS |
Mallard EC, Rees S, Stringer M, Cock ML, Harding R (1998) Effects of chronic placental insufficiency on brain development in fetal sheep. Pediatric Research 43, 262–270.
| Effects of chronic placental insufficiency on brain development in fetal sheep.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaK1cXptFyqsQ%3D%3D&md5=fb2ada7a516ba17dd9bf091dd458b0c7CAS | 9475295PubMed |
Martin JL, Vonnahme KA, Adams DC, Lardy GP, Funston RN (2007) Effects of dam nutrition on growth and reproductive performance of heifer calves. Journal of Animal Science 85, 841–847.
| Effects of dam nutrition on growth and reproductive performance of heifer calves.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2sXit1Wktbg%3D&md5=0a149b6a3def18f2ff8f59f9a081ad57CAS | 17085735PubMed |
Martín NP, Kenyon PR, Morel PCH, Pain SJ, Jenkinson CMC, Hutton PG, Morris ST, Peterson SW, Firth EC, Blair HT (2012) Ewe nutrition in early and mid- to late pregnancy has few effects on fetal development. Animal Production Science 52, 533–539.
| Ewe nutrition in early and mid- to late pregnancy has few effects on fetal development.Crossref | GoogleScholarGoogle Scholar |
McDowall ML, Watson-Haigh NS, Edwards NM, Kadarmideen HN, Nattrass GS, McGrice HA, Hynd PI (2013) Transient treatment of pregnant Merino ewes with modulators of cortisol biosynthesis coinciding with primary wool follicle initiation alters lifetime wool growth. Animal Production Science 53, 1101–1111.
| Transient treatment of pregnant Merino ewes with modulators of cortisol biosynthesis coinciding with primary wool follicle initiation alters lifetime wool growth.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3sXhsVSgsb%2FJ&md5=c1d00f76c9b7e1fb45cf391415a95161CAS |
McKay JA, Mathers JC (2011) Diet induced epigenetic changes and their implications for health. Acta Physiologica 202, 103–118.
| Diet induced epigenetic changes and their implications for health.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3MXmvFGls78%3D&md5=ca027e2b6e1585caa55b3db81ed807aeCAS | 21401888PubMed |
Micke GC, Sullivan TM, Soares Magalhaes RJ, Rolls PJ, Norman ST, Perry VEA (2010a) Heifer nutrition during early- and mid-pregnancy alters fetal growth trajectory and birth weight. Animal Reproduction Science 117, 1–10.
| Heifer nutrition during early- and mid-pregnancy alters fetal growth trajectory and birth weight.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1MXhtlyjt7vO&md5=3dbff7981877e466667c3296b4286d06CAS | 19394770PubMed |
Micke GC, Sullivan TM, Gatford KL, Owens JA, Perry VEA (2010b) Nutrient intake in the bovine during early and mid-pregnancy causes sex-specific changes in progeny plasma IGF-1, liveweight, height and carcass traits. Animal Reproduction Science 121, 208–217.
| Nutrient intake in the bovine during early and mid-pregnancy causes sex-specific changes in progeny plasma IGF-1, liveweight, height and carcass traits.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3cXhtV2hsrrE&md5=bd773eba3bb9a848f15ec776bd040db7CAS | 20591585PubMed |
Micke GC, Sullivan TM, McMillen IC, Gentili S, Perry VEA (2011) Heifer nutrient intake during early- and mid-gestation programs adult offspring adiposity and mRNA expression of growth-related genes in adipose depots. Reproduction 141, 697–706.
| Heifer nutrient intake during early- and mid-gestation programs adult offspring adiposity and mRNA expression of growth-related genes in adipose depots.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3MXmvFCis78%3D&md5=24ea46d33b4f13505b00c7978a04d066CAS | 21310814PubMed |
Morrison JL (2008) Sheep models of intrauterine growth restriction: fetal adaptations and consequences. Clinical and Experimental Pharmacology & Physiology 35, 730–743.
| Sheep models of intrauterine growth restriction: fetal adaptations and consequences.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1cXnsVCmtb4%3D&md5=40d1dc13691ba29411235c0b27979338CAS |
Mossa F, Carter F, Walsh SW, Kenny DA, Smith GW, Ireland JLW, Hildebrandt TB, Lonergan P, Ireland JJ, Evans ACO (2013) Maternal undernutrition in cows impairs ovarian and cardiovascular systems in their offspring. Biology of Reproduction 88, 92
| Maternal undernutrition in cows impairs ovarian and cardiovascular systems in their offspring.Crossref | GoogleScholarGoogle Scholar | 23426432PubMed |
Mühlhäusler BS, Roberts CT, Yuen BSJ, Marrocco E, Budge H, Symonds ME, McFarlane JR, Kauter KG, Stagg P, Pearse JK, McMillen IC (2003) Determinants of fetal leptin synthesis, fat mass, and circulating leptin concentrations in well-nourished ewes in late pregnancy. Endocrinology 144, 4947–4954.
| Determinants of fetal leptin synthesis, fat mass, and circulating leptin concentrations in well-nourished ewes in late pregnancy.Crossref | GoogleScholarGoogle Scholar | 12959967PubMed |
Muhlhausler BS, Adam CL, Findlay PA, Duffield JA, McMillen IC (2006) Increased maternal nutrition alters development of the appetite-regulating network in the brain. The FASEB Journal 20, E556–E565.
| Increased maternal nutrition alters development of the appetite-regulating network in the brain.Crossref | GoogleScholarGoogle Scholar |
Muhlhausler BS, Duffield JA, McMillen IC (2007a) Increased maternal nutrition stimulates peroxisome proliferator activated receptor-γ, adiponectin, and leptin messenger ribonucleic acid expression in adipose tissue before birth. Endocrinology 148, 878–885.
| Increased maternal nutrition stimulates peroxisome proliferator activated receptor-γ, adiponectin, and leptin messenger ribonucleic acid expression in adipose tissue before birth.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2sXhtlOjtbc%3D&md5=63d1fc72bebab20c8f55203e66fb6ed7CAS | 17068138PubMed |
Muhlhausler BS, Duffield JA, McMillen IC (2007b) Increased maternal nutrition increases leptin expression in perirenal and subcutaneous adipose tissue in the postnatal lamb. Endocrinology 148, 6157–6163.
| Increased maternal nutrition increases leptin expression in perirenal and subcutaneous adipose tissue in the postnatal lamb.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2sXhsVers7rF&md5=dd337ae5b273a451fc6859821f9f67b6CAS | 17884936PubMed |
Mühlhäusler BS, Adam CL, McMillen IC (2008) Maternal nutrition and the programming of obesity. Organogenesis 4, 144–152.
| Maternal nutrition and the programming of obesity.Crossref | GoogleScholarGoogle Scholar | 19279726PubMed |
Ojha S, Robinson L, Yazdani M, Symonds ME, Budge H (2013) Brown adipose tissue genes in pericardial adipose tissue of newborn sheep are downregulated by maternal nutrient restriction in late gestation. Pediatric Research 74, 246–251.
| Brown adipose tissue genes in pericardial adipose tissue of newborn sheep are downregulated by maternal nutrient restriction in late gestation.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3sXhsVWqtrfE&md5=3439926d1878d5069d4714bb7870fef2CAS | 23788058PubMed |
Ojha S, Symonds ME, Budge H (2014) Suboptimal maternal nutrition during early-to-mid gestation in the sheep enhances pericardial adiposity in the near-term fetus. Reproduction, Fertility and Development
| Suboptimal maternal nutrition during early-to-mid gestation in the sheep enhances pericardial adiposity in the near-term fetus.Crossref | GoogleScholarGoogle Scholar |
Oldham CM, Thompson AN, Ferguson MB, Gordon DJ, Kearney GA, Paganoni BL (2011) The birthweight and survival of Merino lambs can be predicted from the profile of liveweight changes of their mothers during pregnancy. Animal Production Science 51, 776–783.
| The birthweight and survival of Merino lambs can be predicted from the profile of liveweight changes of their mothers during pregnancy.Crossref | GoogleScholarGoogle Scholar |
Oliver MH, Harding JE, Breier BH, Evans PC, Gluckman PD (1992) The nutritional regulation of circulating placental lactogen in fetal sheep. Pediatric Research 31, 520–523.
| The nutritional regulation of circulating placental lactogen in fetal sheep.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaK38XktVKrurk%3D&md5=530bb271ac1372600855798055b1c942CAS | 1603632PubMed |
Owens JA, Thavaneswaran P, De Blasio MJ, McMillen IC, Robinson JS, Gatford KL (2007) Sex-specific effects of placental restriction on components of the metabolic syndrome in young sheep. American Journal of Physiology. Endocrinology and Metabolism 292, E1879–E1889.
| Sex-specific effects of placental restriction on components of the metabolic syndrome in young sheep.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2sXmvF2mur0%3D&md5=a04f17e513691bd1d216f2460e745eb1CAS | 17327366PubMed |
Park CS (2005) Role of compensatory mammary growth in epigenetic control of gene expression. The FASEB Journal 19, 1586–1591.
| Role of compensatory mammary growth in epigenetic control of gene expression.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2MXhtV2nurbM&md5=d61dbbdfd7affd6c093b9b73a39e245cCAS | 16195367PubMed |
Paten AM, Kenyon PR, Lopez-Villalobos N, Peterson SW, Jenkinson CMC, Pain SJ, Blair HT (2013) Maternal nutrition during early and mid-to-late pregnancy: comparative effects on milk production of twin-born ewe progeny during their first lactation. Journal of Animal Science 91, 676–684.
| Maternal nutrition during early and mid-to-late pregnancy: comparative effects on milk production of twin-born ewe progeny during their first lactation.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3sXlvVKnurc%3D&md5=68d35b6ebf9741cf2431fdeb30f2e658CAS | 23230109PubMed |
Peel RK, Eckerle GJ, Anthony RV (2012) Effects of overfeeding naturally-mated adolescent ewes on maternal, fetal, and postnatal lamb growth. Journal of Animal Science 90, 3698–3708.
| Effects of overfeeding naturally-mated adolescent ewes on maternal, fetal, and postnatal lamb growth.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC38XhslOit7nP&md5=5f74f2dd8bd8ab755137bc2f24adbbf7CAS | 22665677PubMed |
Pope M, Budge H, Symonds ME (2014) The developmental transition of ovine adipose tissue through early life. Acta Physiologica 210, 20–30.
| The developmental transition of ovine adipose tissue through early life.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3sXhvFalurzE&md5=26e9d9a8d24aaf047c18f7097504d73dCAS | 23351024PubMed |
Quigley SP, Kleemann DO, Kakar MA, Owens JA, Nattrass GS, Maddocks S, Walker SK (2005) Myogenesis in sheep is altered by maternal feed intake during the peri-conception period. Animal Reproduction Science 87, 241–251.
| Myogenesis in sheep is altered by maternal feed intake during the peri-conception period.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DC%2BD2MzhvFyrsA%3D%3D&md5=67dd903a83cda2d90dcbb3d3d447f428CAS | 15911174PubMed |
Quigley SP, Greenwood PL, Kleemann DO, Owens JA, Bawden CS, Nattrass GS (2015) Myogenesis in small and large fetuses at three stages of pregnancy. Animal Production Science 55, 207–212.
| Myogenesis in small and large fetuses at three stages of pregnancy.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC2MXlsFelsg%3D%3D&md5=21d3e7c4f7e60c387c09581dff9fb74cCAS |
Radunz AE, Fluharty FL, Relling AE, Felix TL, Shoup LM, Zerby HN, Loerch SC (2012) Prepartum dietary energy source fed to beef cows: II. Effects on progeny postnatal growth, glucose tolerance, and carcass composition. Journal of Animal Science 90, 4962–4974.
| Prepartum dietary energy source fed to beef cows: II. Effects on progeny postnatal growth, glucose tolerance, and carcass composition.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3sXisFSjs70%3D&md5=59b378d52e53714b46c2836b372a308aCAS | 22952375PubMed |
Rae MT, Palassio S, Kyle CE, Brooks AN, Lea RG, Miller DW, Rhind SM (2001) Effects of maternal undernutrition during pregnancy on early ovarian development and subsequent follicular development in sheep fetuses. Journal of Reproduction and Fertility 122, 915–922.
| Effects of maternal undernutrition during pregnancy on early ovarian development and subsequent follicular development in sheep fetuses.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD38XhvVWisw%3D%3D&md5=a06782b64e164657160fd3a793b93ba7CAS |
Rattanatray L, MacLaughlin SM, Kleemann DO, Walker SK, Muhlausler BS, McMillen IC (2010) Impact of maternal periconceptual overnutrition on fat mass and expression of adipogenic and lipogenic genes in visceral and subcutaneous fat depots in the postnatal lamb. Endocrinology 151, 5195–5205.
| Impact of maternal periconceptual overnutrition on fat mass and expression of adipogenic and lipogenic genes in visceral and subcutaneous fat depots in the postnatal lamb.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3cXhsVKks7jI&md5=388064d2b6218ea0baa9d258360c263fCAS | 20861234PubMed |
Redmer DA, Wallace JM, Reynolds LP (2004) Effect of nutrient intake during pregnancy on fetal and placental growth and vascular development. Domestic Animal Endocrinology 27, 199–217.
| Effect of nutrient intake during pregnancy on fetal and placental growth and vascular development.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DC%2BD2cvot1KksQ%3D%3D&md5=27610916b784fd7acc0ce6ff92c55503CAS | 15451070PubMed |
Reynolds LP, Borowicz PP, Caton JS, Vonnahme KA, Luther JS, Buchanan DS, Hafez SA, Grazul-Bilska AT, Redmer DA (2010) Uteroplacental vascular development and placental function: an update. The International Journal of Developmental Biology 54, 355–365.
| Uteroplacental vascular development and placental function: an update.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3cXltVajtbY%3D&md5=866e4518886b5ec4136810d90cc7d68fCAS | 19924632PubMed |
Robinson DL, Cafe LM, Greenwood PL (2013) Developmental programming in cattle: consequences for growth, efficiency, carcass, muscle, and beef quality characteristics. Journal of Animal Science 91, 1428–1442.
| Developmental programming in cattle: consequences for growth, efficiency, carcass, muscle, and beef quality characteristics.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3sXmsFKnu7s%3D&md5=104ad8e0fa658398fa86bd16a69b3fc7CAS | 23230118PubMed |
Satterfield MC, Dunlap KA, Keisler DH, Bazer FW, Wu G (2013) Arginine nutrition and fetal brown adipose development in nutrient-restricted sheep. Amino Acids 45, 489–499.
| Arginine nutrition and fetal brown adipose development in nutrient-restricted sheep.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3sXht1OitLrL&md5=3ac31fea72b6e94b94c079a374eb9c1fCAS | 22130738PubMed |
Schinckel PG, Short BF (1961) The influence of nutritional level during pre-natal and early post-natal life on adult fleece and body characteristics. Australian Journal of Agricultural Research 12, 176–202.
| The influence of nutritional level during pre-natal and early post-natal life on adult fleece and body characteristics.Crossref | GoogleScholarGoogle Scholar |
Sciascia Q, Scales F, van der Linden D, Wards N, Oliver M, Blair H, McCoard S (2015) Nutritional plane of twin-bearing ewes alters fetal mammary gland biochemical composition and mTOR/MAPK pathway signaling. Journal of Animal Science 93, 699–708.
| Nutritional plane of twin-bearing ewes alters fetal mammary gland biochemical composition and mTOR/MAPK pathway signaling.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC2MXkt1Wks7k%3D&md5=92d2f4446f665840fe547468c2bf875aCAS | 26020751PubMed |
Sullivan TM, Micke GC, Greer RM, Irving-Rodgers HF, Rodgers RJ, Perry VEA (2009) Dietary manipulation of Bos indicus × heifers during gestation affects the reproductive development of their heifer calves. Reproduction, Fertility and Development 21, 773–784.
| Dietary manipulation of Bos indicus × heifers during gestation affects the reproductive development of their heifer calves.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1MXnvVOhu7Y%3D&md5=fc89920ab2d86c139f536efdddbee88bCAS |
Sullivan TM, Micke GC, Greer RM, Perry VEA (2010) Dietary manipulation of Bos indicus × heifers during gestation affects the prepubertal reproductive development of their bull calves. Animal Reproduction Science 118, 131–139.
| Dietary manipulation of Bos indicus × heifers during gestation affects the prepubertal reproductive development of their bull calves.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3cXhtVGltbo%3D&md5=8a798c8b797b42762c3de2a29b3f6190CAS | 19671489PubMed |
Suteevun-Phermthai T, Curchoe CL, Evans AC, Boland E, Rizos D, Fair T, Duffy P, Sung LY, Du F, Chaubal S, Xu J, Wechayant T, Yang X, Lonergan P, Parnpai R, Tian XC (2009) Allelic switching of the imprinted IGF2R gene in cloned bovine fetuses and calves. Animal Reproduction Science 116, 19–27.
| Allelic switching of the imprinted IGF2R gene in cloned bovine fetuses and calves.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1MXhtVKkt7jM&md5=0dff2a0b1b6e747d962dc456caf50503CAS | 19217227PubMed |
Symonds ME, Pope E, Budge H (2015) The ontogeny of brown adipose tissue. Annual Review of Nutrition 35,
| The ontogeny of brown adipose tissue.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC2MXhsFersLbP&md5=721c5b5d977a76ef9fbc98163860a0f3CAS | 26076904PubMed |
Taga H, Chilliard Y, Meunier B, Chambon C, Picard B, Zingaretti MC, Cinti S, Bonnet M (2012) Cellular and molecular large-scale features of fetal adipose tissue: is bovine perirenal adipose tissue brown? Journal of Cellular Physiology 227, 1688–1700.
| Cellular and molecular large-scale features of fetal adipose tissue: is bovine perirenal adipose tissue brown?Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC38XlvVGgsQ%3D%3D&md5=a59c3b7aa20a34779afe3fd3dc869f41CAS | 21678425PubMed |
Tellam RL, Cockett NE, Vuocolo T, Bidwell CA (2012) Genes contributing to genetic variation of muscling in sheep. Frontiers in Genetics 3, article 164
| Genes contributing to genetic variation of muscling in sheep.Crossref | GoogleScholarGoogle Scholar |
Thompson AN, Ferguson MB, Gordon DJ, Kearney GA, Oldham CM, Paganoni BL (2011) Improving the nutrition of Merino ewes during pregnancy increases the fleece weight and reduces the fibre diameter of their progeny’s wool during their lifetime and these effects can be predicted from the ewe’s livewight profile. Animal Production Science 51, 794–804.
| Improving the nutrition of Merino ewes during pregnancy increases the fleece weight and reduces the fibre diameter of their progeny’s wool during their lifetime and these effects can be predicted from the ewe’s livewight profile.Crossref | GoogleScholarGoogle Scholar |
Todd SE, Oliver MH, Jaquiery AL, Bloomfield FH, Harding JE (2009) Periconceptual undernutrition of ewes impairs glucose tolerance in their adult offspring. Pediatric Research 65, 409–413.
| Periconceptual undernutrition of ewes impairs glucose tolerance in their adult offspring.Crossref | GoogleScholarGoogle Scholar | 19092719PubMed |
Tong JF, Yan X, Zhu MJ, Ford SP, Nathanielsz PW, Du M (2009) Maternal obesity downregulates myogenesis and β-catenin signaling in fetal skeletal muscle. American Journal of Physiology. Endocrinology and Metabolism 296, E917–E924.
| Maternal obesity downregulates myogenesis and β-catenin signaling in fetal skeletal muscle.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1MXkvVyhtbs%3D&md5=ff0e48ea81bb34cada84ce098b28ef36CAS | 19176350PubMed |
Tuersunjiang N, Odhiambo JF, Long NM, Shasa DR, Nathanielsz PW, Ford SP (2013) Diet reduction to requirements in obese/overfed ewes from early gestation prevents glucose/insulin dysregulation and returns fetal adiposity and organ development to control levels. American Journal of Physiology. Endocrinology and Metabolism 305, E868–E878.
| Diet reduction to requirements in obese/overfed ewes from early gestation prevents glucose/insulin dysregulation and returns fetal adiposity and organ development to control levels.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3sXhslejtbvI&md5=a919ce0fdf894b8b8bc702df8d90c3e0CAS | 23921140PubMed |
Underwood KR, Tong JF, Price PL, Roberts AJ, Grings EE, Hess BW, Means WJ, Du M (2010) Nutrition during mid to late gestation affects growth, adipose tissue deposition, and tenderness in cross-bred beef steers. Meat Science 86, 588–593.
| Nutrition during mid to late gestation affects growth, adipose tissue deposition, and tenderness in cross-bred beef steers.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3cXhtFCrur%2FP&md5=90c649ccf7c8c271b0b4f5290b9953ebCAS | 20659786PubMed |
van der Linden DS, Kenyon PR, Blair HT, Lopez-Villalobos N, Jenkinson CMC, Peterson SW, Mackenzie DDS (2009) Effects of ewe size and nutrition on fetal mammary gland development and lactational performance od offspring at their first lactation. Journal of Animal Science 87, 3944–3954.
| Effects of ewe size and nutrition on fetal mammary gland development and lactational performance od offspring at their first lactation.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1MXhsVOhs7bO&md5=930e9193de9fd9c78befc215fac63647CAS | 19684261PubMed |
van der Linden DS, Kenyon PR, Lopez-Villalobos N, Jenkinson CMC, Peterson SW, Blair HT (2010) Effects of ewe size and nutrition during pregnancy on performance of 2-year-old female offspring. The Journal of Agricultural Science 148, 465–475.
| Effects of ewe size and nutrition during pregnancy on performance of 2-year-old female offspring.Crossref | GoogleScholarGoogle Scholar |
Vonnahme KA (2012) How the maternal environment impacts fetal and placental development: implications for livestock production. Animal Reproduction 9, 789–797.
Wallace LR (1948) The growth of lambs before and after birth in relation to the level of nutrition. Part III. The Journal of Agricultural Science 38, 367–401.
| The growth of lambs before and after birth in relation to the level of nutrition. Part III.Crossref | GoogleScholarGoogle Scholar |
Wallace JM, Bourke DA, Aitken RP, Cruickshank MA (1999) Switching maternal dietary intake at the end of the first trimester has profound effects on placental development and fetal growth in adolescent ewes carrying singleton foetuses. Biology of Reproduction 61, 101–110.
| Switching maternal dietary intake at the end of the first trimester has profound effects on placental development and fetal growth in adolescent ewes carrying singleton foetuses.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaK1MXktFKgtbc%3D&md5=16a0929bd46c0e2f4a7c856f05b88b23CAS | 10377037PubMed |
Wallace JM, Bourke DA, Aitken RP, Palmer RM, Da Silva P, Cruickshank MA (2000) Relationship between nutritionally-mediated placental growth restriction and fetal growth, body composition and endocrine status during late gestation in adolescent sheep. Placenta 21, 100–108.
| Relationship between nutritionally-mediated placental growth restriction and fetal growth, body composition and endocrine status during late gestation in adolescent sheep.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD3cXhvFCjtbg%3D&md5=1922392f9b9d3a81fc8db45f5c7fb730CAS | 10692257PubMed |
Wallace JM, Aitken RP, Milne JS, Hay WW (2004) Nutritionally mediated placental growth restriction in the growing adolescent: consequences for the fetus. Biology of Reproduction 71, 1055–1062.
| Nutritionally mediated placental growth restriction in the growing adolescent: consequences for the fetus.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2cXnvVGqtrk%3D&md5=28efe7ab157979644bb57bde0f9b5b34CAS | 15201203PubMed |
Wallace JM, Milne JS, Aitken RP (2005) The effect of overnourishing singleton-bearing adult ewes on nutrient partitioning to the gravid uterus. British Journal of Nutrition 94, 533–539.
| The effect of overnourishing singleton-bearing adult ewes on nutrient partitioning to the gravid uterus.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2MXhtF2ks7vK&md5=f32083de518886f4e0ad123c1066dedeCAS | 16197577PubMed |
Wallace JM, Luther JS, Milne JS, Aitken RP, Redmer DA, Reynolds LP, Hay WW (2006) Nutritional modulation of adolescent pregnancy outcome: a review. Placenta 27, 61–68.
| Nutritional modulation of adolescent pregnancy outcome: a review.Crossref | GoogleScholarGoogle Scholar |
Wallace JM, Milne JS, Adam CL, Aitken RP (2012) Adverse metabolic phenotype in low-birth-weight lambs and its modification by postnatal nutrition. British Journal of Nutrition 107, 510–522.
| Adverse metabolic phenotype in low-birth-weight lambs and its modification by postnatal nutrition.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC38XhslCjs7g%3D&md5=52683cf2bbd9a5273e6ee9ddb03efbe0CAS | 21733295PubMed |
Wallace JM, Milne JS, Aitken RP, Adam CL (2014) Impact of embryo donor adiposity, birth weight and gender on early postnatal growth, glucose metabolism and body composition in the young lamb. Reproduction, Fertility and Development 26, 665–681.
| Impact of embryo donor adiposity, birth weight and gender on early postnatal growth, glucose metabolism and body composition in the young lamb.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC2cXhtVentb3K&md5=58d6921bc7920e4c73be916eba5ec84cCAS |
Warnes KE, Morris MJ, Symonds ME, Phillips ID, Clarke IJ, Owens JA, McMillen IC (1998) Effects of increasing gestation, cortisol and maternal undernutrition on hypothalamic neuropeptide Y expression in the sheep fetus. Journal of Neuroendocrinology 10, 51–57.
| Effects of increasing gestation, cortisol and maternal undernutrition on hypothalamic neuropeptide Y expression in the sheep fetus.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaK1cXhtFOiu7k%3D&md5=8ced45d916272d4e588e260b757cf76eCAS | 9510058PubMed |
Wickham GA, Schoknecht PA, Currie WB, Bell AW, McCutcheon SN (1992) Suppression of secondary wool follicle development by administration of placental lactogen to ovine foetuses. Proceedings of the New Zealand Society of Animal Production 52, 277–279.
Wilkins JF, Fry RC, Hearnshaw H, Cafe LM, Greenwood PL (2006) Ovarian activity in heifers at 30 months of age following high or low growth in utero or form birth to weaning. Short communication 17. In ‘Australian Society of Animal Production 26th biennial conference’.
Wu G, Bazer FW, Wallace JM, Spencer TE (2006) Intrauterine growth retardation: implications for the animal sciences. Journal of Animal Science 84, 2316–2337.
| Intrauterine growth retardation: implications for the animal sciences.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD28XovFGktLs%3D&md5=7d8bf86982878ffbb5b1a176aa6293eeCAS | 16908634PubMed |
Yan X, Zhu MJ, Xu W, Tong JF, Ford SP, Nathanielsz PW, Du M (2010) Up-regulation of toll-like receptor 4/nuclear factor-ᴋB signaling is associated with enhanced adipogenesis and insulin resistance in fetal skeletal muscle of obese sheep at late gestation. Endocrinology 151, 380–387.
| Up-regulation of toll-like receptor 4/nuclear factor-ᴋB signaling is associated with enhanced adipogenesis and insulin resistance in fetal skeletal muscle of obese sheep at late gestation.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3cXls1Gitw%3D%3D&md5=ae3501ae5720ff2f82831c366e991562CAS | 19887565PubMed |
Yan X, Huang Y, Zhao J-X, Long NM, Uthlaut AB, Zhu M-J, Ford SP, Nathanielsz PW, Du M (2011) Maternal obesity-impaired insulin signaling in sheep and induced lipid accumulation and fibrosis in skeletal muscle of offspring. Biology of Reproduction 85, 172–178.
| Maternal obesity-impaired insulin signaling in sheep and induced lipid accumulation and fibrosis in skeletal muscle of offspring.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3MXotFOlsL0%3D&md5=d7cc3df560068403e04a99642a30ddbfCAS | 21349823PubMed |
Yates DT, Macko AR, Nearing M, Chen X, Rhoads RP, Limesand SW (2012) Developmental programming in response to interuterine growth restriction impairs myoblast function and skeletal muscle metabolism. Journal of Pregnancy 2012, Article ID 631038
| Developmental programming in response to interuterine growth restriction impairs myoblast function and skeletal muscle metabolism.Crossref | GoogleScholarGoogle Scholar |
Yates DT, Clarke DS, Macko AR, Anderson MJ, Shelton LA, Nearing M, Allen RE, Rhoads RP, Limesand SW (2014) Myoblasts from intrauterine growth-restricted sheep fetuses exhibit intrinsic deficiencies in proliferation that contribute to smaller semitendinosus myofibres. The Journal of Physiology 592, 3113–3125.
| Myoblasts from intrauterine growth-restricted sheep fetuses exhibit intrinsic deficiencies in proliferation that contribute to smaller semitendinosus myofibres.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC2cXhtFCksrjO&md5=db47347054e082b1e21b5cac14af3273CAS | 24860171PubMed |
Young JM, Thompson AN, Curnow M, Oldham CM (2011) Whole-farm profit and the and the optimum maternal liveweight profile of Merino ewe flocks lambing in winter and spring are influenced by the effects of ewe nutrition on the progeny’s survival and lifetime wool production. Animal Production Science 51, 821–833.
| Whole-farm profit and the and the optimum maternal liveweight profile of Merino ewe flocks lambing in winter and spring are influenced by the effects of ewe nutrition on the progeny’s survival and lifetime wool production.Crossref | GoogleScholarGoogle Scholar |
Zhang S, Regnault TRH, Barker PL, Botting KJ, McMillen IC, McMillan CM, Roberts CT, Morrison JL (2015) Placental adaptations in growth restriction. Nutrients 7, 360–389.
| Placental adaptations in growth restriction.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC2MXntFGlsL8%3D&md5=c33b6a268e069d465d84719a161280ebCAS | 25580812PubMed |
Zhu M-J, Ford SP, Nathanielsz PW, Du M (2004) Effect of maternal nutrient restriction in sheep on the development of fetal skeletal muscle. Biology of Reproduction 71, 1968–1973.
| Effect of maternal nutrient restriction in sheep on the development of fetal skeletal muscle.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2cXhtVWgsr3L&md5=b00c54b1809e163411282eb3af16a800CAS | 15317692PubMed |
Zhu MJ, Ford SP, Means WJ, Hess BW, Nathanielsz PW, Du M (2006) Maternal nutrient restriction affects properties of skeletal muscle in offspring. The Journal of Physiology 575, 241–250.
| Maternal nutrient restriction affects properties of skeletal muscle in offspring.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD28Xpslaitbo%3D&md5=1b656d03c134451c66ca499f9ca90412CAS | 16763001PubMed |
Zhu MJ, Han B, Tong J, Ma C, Kimzey JM, Underwood KR, Xiao Y, Hess BW, Ford SP, Nathanielsz PW, Du M (2008) AMP-activated protein kinase signalling pathways are down regulated and skeletal muscle development impaired in fetuses of obese, over-nourished sheep. The Journal of Physiology 586, 2651–2664.
| AMP-activated protein kinase signalling pathways are down regulated and skeletal muscle development impaired in fetuses of obese, over-nourished sheep.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1cXmsFOhtb4%3D&md5=dd97dc1c5bddb6252a5fd8727ecf5846CAS | 18372306PubMed |
