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Article << Previous     |     Next >>   Contents Vol 60(5)

Synthesis of a Reversible Streptavidin Binder for Biomimetic Assemblies

Nathan W. Moore A, Anthony R. C. Delacruz A, Katherine S. Lancaster B, Thorsten Dieckmann C, Tonya L. Kuhl A D

A Department of Chemical Engineering and Materials Science, University of California at Davis, 1 Shields Ave, Davis, CA 95616, USA.
B Department of Chemistry, University of California at Davis, 1 Shields Ave, Davis, CA 95616, USA.
C Department of Chemistry, University of Waterloo, 200 University Ave West, Waterloo, ON N2L 3G1, Canada.
D Corresponding author. Email: tlkuhl@ucdavis.edu
 
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Abstract

The biotin/streptavidin ligand/receptor pair is used extensively in biotechnology. However, less is known about HABA (2-(4-hydroxyphenylazo)benzoic acid), which binds to streptavidin with a bond energy and dissociation constant that more closely mimics antibody/antigen interactions. In this work we demonstrate some of HABA’s useful properties that may make it a good substitute for biotin in a broad range of biochemical research. Specifically, we investigate its ease of conjugation to an anchoring pegylated lipid, characterization with MALDI, NMR, and visible-wavelength spectroscopies, and incorporation into lipid vesicles.

   
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