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Article << Previous     |     Next >>   Contents Vol 62(1)

Diversity-Oriented Synthesis of Substituted Furo[2,3-b]pyrazines

Vaibhav P. Mehta A, Sachin G. Modha A, Denis Ermolat’ev A, Kristof Van Hecke B, Luc Van Meervelt B, Erik V. Van der Eycken A C

A Laboratory for Organic and Microwave-Assisted Chemistry (LOMAC), Department of Chemistry, Katholieke Universiteit Leuven, Celestijnenlaan 200F, 3001, Leuven, Belgium.
B Biomolecular Architecture, Department of Chemistry, Katholieke Universiteit Leuven, Celestijnenlaan 200F, 3001, Leuven, Belgium.
C Corresponding author. Email: erik.vandereycken@chem.kuleuven.be
 
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Abstract

A highly efficient method for the synthesis of diversely substituted furo[2,3-b]pyrazines has been elaborated. The Ag+- or iodine-mediated electrophilic cyclization of readily generated 5-chloro-3-substituted ethynyl-1-(4-methoxybenzyl)-pyrazin-2(1H)-ones affords substituted furo[2,3-b]pyrazines, which undergo various palladium catalyzed reactions to generate a library of difficult to attain diversely substituted furo[2,3-b]pyrazines.

   
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