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Australian Journal of Chemistry Australian Journal of Chemistry Society
An international journal for chemical science
RESEARCH ARTICLE

A Simple One-Pot, Three Component Synthesis of 3-Arylpyrimido[4,5-c]pyridazine-5,7(6H,8H)-diones and their Sulfur Analogues as Potential Monoamine Oxidase Inhibitors

Mehdi Rimaz A , Jabbar Khalafy A C , Nader Noroozi Pesyan A and Rolf H. Prager B
+ Author Affiliations
- Author Affiliations

A Chemistry Department, Urmia University, Urmia 57154, Iran.

B School of Chemistry, Physics and Earth Sciences, Flinders University, Adelaide, SA 5001, Australia.

C Corresponding author. Email: j.khalafi@mail.urmia.ac.ir; jkhalafi@yahoo.com

Australian Journal of Chemistry 63(3) 507-510 https://doi.org/10.1071/CH09569
Submitted: 27 October 2009  Accepted: 18 January 2010   Published: 26 March 2010

Abstract

Several new 3-arylpyrimido[4,5-c]pyridazine-5,7(6H,8H)-diones and 3-aryl-5-oxo-7-thioxo-7,8-dihydropyrimido[4,5-c]pyridazin-5(6H)-ones have been synthesized by a three-component reaction of barbituric acid or thiobarbituric acid with arylglyoxals in the presence of a catalytic amount of pyridine and hydrazine hydrate at room temperature in water.


Acknowledgements

The authors express their thanks to Urmia University for financial support.


References


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