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Article << Previous     |     Next >>   Contents Vol 63(3)

A Simple One-Pot, Three Component Synthesis of 3-Arylpyrimido[4,5-c]pyridazine-5,7(6H,8H)-diones and their Sulfur Analogues as Potential Monoamine Oxidase Inhibitors

Mehdi Rimaz A, Jabbar Khalafy A C, Nader Noroozi Pesyan A, Rolf H. Prager B

A Chemistry Department, Urmia University, Urmia 57154, Iran.
B School of Chemistry, Physics and Earth Sciences, Flinders University, Adelaide, SA 5001, Australia.
C Corresponding author. Email: j.khalafi@mail.urmia.ac.ir; jkhalafi@yahoo.com
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Several new 3-arylpyrimido[4,5-c]pyridazine-5,7(6H,8H)-diones and 3-aryl-5-oxo-7-thioxo-7,8-dihydropyrimido[4,5-c]pyridazin-5(6H)-ones have been synthesized by a three-component reaction of barbituric acid or thiobarbituric acid with arylglyoxals in the presence of a catalytic amount of pyridine and hydrazine hydrate at room temperature in water.

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