Australin E Isolated from the Soft Coral Cladiella sp. Collected in Pohnpei Activates the Inositol 5-Phosphatase SHIP1

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Contents Vol 63(6)

doi:10.1071/CH10053

Australin E Isolated from the Soft Coral Cladiella sp. Collected in Pohnpei Activates the Inositol 5-Phosphatase SHIP1

David E. Williams ^A, Ashraf Amlani ^B, Ariyanti S. Dewi ^A, Brian O. Patrick ^A, Leen van Ofwegen ^C, Alice L.-F. Mui ^B, Raymond J. Andersen ^A ^D

^A Departments of Chemistry and Earth & Ocean Sciences, University of British Columbia, Vancouver, B.C. V6T 1Z1, Canada.
^B Department of Surgery, The Jack Bell Research Centre, University of British Columbia, B.C. V6H 3Z6, Canada.
^C National Museum of Natural History, PO Box 9517, 2300 RA Leiden, The Netherlands.
^D Corresponding author. Email: randersn@interchange.ubc.ca





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Australian Journal of Chemistry 63(6) 895–900 http://dx.doi.org/10.1071/CH10053
Submitted: 28 January 2010 Accepted: 18 March 2010 Published online: 11 June 2010

Abstract

Four new diterpenoids, australins E–H (1–4), have been isolated from the marine soft coral Cladiella sp. collected in Pohnpei. The structures of 1–4 were elucidated by analysis of their NMR and mass spectrometry data combined with an X-ray diffraction analysis of australin E (1). Australin E (1) activates the inositol 5-phosphatase SHIP1 in vitro.