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Australian Journal of Chemistry Australian Journal of Chemistry Society
An international journal for chemical science
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Water-soluble Bis(thiosemicarbazonato)copper(ii) Complexes

Gojko Buncic A , James L. Hickey A , Christine Schieber A , Jonathan M. White A , Peter J. Crouch B , Anthony R. White B , Zhiguang Xiao A , Anthony G. Wedd A and Paul S. Donnelly A C
+ Author Affiliations
- Author Affiliations

A School of Chemistry and Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Melbourne, Vic. 3010, Australia.

B Centre for Neuroscience and Department of Pathology, University of Melbourne, Parkville, Melbourne, Vic. 3010, Australia.

C Corresponding author. Email: pauld@unimelb.edu.au

Australian Journal of Chemistry 64(3) 244-252 https://doi.org/10.1071/CH10463
Submitted: 17 December 2010  Accepted: 17 January 2011   Published: 11 March 2011

Abstract

The synthesis of four new water-soluble bis(thiosemicarbazone) ligands and their copper(ii) complexes is presented and their potential to be new ligands for copper radiopharmaceuticals is discussed. The ligands and complexes have been characterized by a combination of NMR spectroscopy, mass spectrometry, and X-ray crystallography. The electrochemical behaviour of two of the copper(ii) complexes was investigated by cyclic voltammetry and revealed that both complexes exhibited a quasi-reversible redox process attributed to a CuII/CuI process. Two of the new ligands were radiolabelled with positron-emitting 64Cu with a view to assessing their potential as ligands that bind radioactive copper isotopes for application in diagnostic radiopharmaceuticals. The cellular uptake of the copper complexes was investigated in SH-SY5Y cells.


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