Antitumor Activities and Structure–Activity Relationship of Phosphotriester Derivatives of Homocamptothecin Based on a Semisynthetic Route

doi:10.1071/CH11315

Antitumor Activities and Structure–Activity Relationship of Phosphotriester Derivatives of Homocamptothecin Based on a Semisynthetic Route

Yong-Qiang Zhang ^A ^E, Huo-Jun Zhang ^B ^E, Jing Zhang ^A, Juan Wang ^C, Jian-Zhong Yao ^A, Lin-Jian Zhu ^A, Chun-Lin Zhuang ^A, Sheng-Zheng Wang ^A, Guo-Qiang Dong ^A, Chun-Quan Sheng ^A ^D, Zhen-Yuan Miao ^A ^D and Wan-Nian Zhang ^A ^D

^A School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, P. R. China.
^B Department of Radiology, Section of Oncologic Intervention, Changhai Hospital, Second Military Medical University, 168 Changhai Road, Shanghai 200433, P. R. China.
^C Department of Chemistry, Fudan University, 220 Handan Road, Shanghai 200433, P. R. China.
^D Corresponding authors. Email: zhangwnk@hotmail.com; miaozhenyuan@hotmail.com; Shengcq@hotmail.com.
^E These two authors contributed equally to this work.

Australian Journal of Chemistry 64(12) 1547-1553 http://dx.doi.org/10.1071/CH11315
Submitted: 27 July 2011 Accepted: 9 September 2011 Published: 17 October 2011