Peptide Nucleic Acid Monomers: A Convenient and Efficient Synthetic Approach to Fmoc/Boc Monomers
Elisse C. Browne A , Steven J. Langford B and Belinda M. Abbott A C
+ Author Affiliations
- Author Affiliations
A La Trobe Institute of Molecular Science and Department of Chemistry, La Trobe University, Bundoora, Vic. 3086, Australia.
B School of Chemistry, Monash University, Clayton, Vic. 3800, Australia.
C Corresponding author. Email: b.abbott@latrobe.edu.au
Australian Journal of Chemistry 65(5) 539-544 https://doi.org/10.1071/CH11471
Submitted: 12 December 2011 Accepted: 10 February 2012 Published: 14 May 2012
Abstract
A convenient and cost-effective method for the synthesis of Fmoc/Boc-protected peptide nucleic acid monomers is described. The Fmoc/Boc strategy was developed in order to eliminate the solubility issues during peptide nucleic acid solid-phase synthesis, in particular that of the cytosine monomer, that occurred when using the commercialized Bhoc chemistry approach.
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