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Article << Previous     |     Next >>   Contents Vol 65(4)

A New and Efficient Procedure for Friedländer Synthesis of Quinolines in Low Melting Tartaric Acid-Urea Mixtures

Fei-Ping Ma A , Gui-Tian Cheng B , Zhi-Guo He C and Zhan-Hui Zhang A D

A College of Chemistry and Material Science, Hebei Normal University, Shijiazhuang 050024, P. R. China.
B Hebei Chemical and Pharmaceutical Vocational Technology College, Shijiazhuang 050026, P. R. China.
C College of Resources and Environment, Hebei Normal University, Shijiazhuang 050024, P. R. China.
D Corresponding author. Email: zhanhui@126.com

Australian Journal of Chemistry 65(4) 409-416 http://dx.doi.org/10.1071/CH12025
Submitted: 19 January 2012  Accepted: 24 February 2012   Published: 27 March 2012


 
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Abstract

A general, efficient and green method for the synthesis of quinoline derivatives via the Friedländer heteroannulation reaction of 2-aminoaryl ketones and α-methylene ketones has been developed, employing low melting mixtures of L-(+)-tartaric acid and urea derivatives as an inexpensive, non-toxic, easily biodegradable reaction medium. The melt acts as both the reaction medium and catalyst, furnishing quinolines in high to excellent yields.





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