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Article << Previous     |     Next >>   Contents Vol 66(1)

Synthesis and Self-Assembly of a Peptide–Amphiphile as a Drug Delivery Vehicle

Soo Jung Son A , Margaret A. Brimble A D , Sunghyun Yang A , Paul W. R. Harris A , Tom Reddingius A , Benjamin W. Muir B , Oliver E. Hutt B , Lynne Waddington B , Jian Guan C and G. Paul Savage B D

A School of Chemical Sciences, The University of Auckland, 23 Symonds Street, Auckland 1010, New Zealand.
B CSIRO Materials Science and Engineering, Bayview Avenue, Clayton, Vic. 3168, Australia.
C Liggins Institute, Faculty of Medicince, The University of Auckland, 23 Symonds Street, Auckland 1010, New Zealand.
D Corresponding authors. Email: m.brimble@auckland.ac.nz; paul.savage@csiro.au

Australian Journal of Chemistry 66(1) 23-29 http://dx.doi.org/10.1071/CH12347
Submitted: 23 July 2012  Accepted: 9 October 2012   Published: 12 November 2012


 
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Abstract

The formation of functional liposomes by the self assembly of a peptide–amphiphile that comprises the neuroprotective tripeptide motif glycyl-prolyl-glutamic acid linked to a hydrophobic moiety is reported. The self-assembled peptide–lipid conjugate displays long range order and can be dispersed as nanometre sized particles.





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